Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ian J. McGough"'
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100560- (2021)
Summary: This one-step method generates, for any locus, a conditional knockout allele in Drosophila. The allele carries a bright fluorescent marker for easy screening and an attP landing site for subsequent genetic manipulations. After removing the s
Externí odkaz:
https://doaj.org/article/8652a259723149758a35c0d9c07f0b3d
Autor:
Ian J. McGough, Reinoud E. A. de Groot, Adam P. Jellett, Marco C. Betist, Katherine C. Varandas, Chris M. Danson, Kate J. Heesom, Hendrik C. Korswagen, Peter J. Cullen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Sustained Wnt secretion requires the endosomal SNX3-retromer complex for endosome-to-trans-Golgi network transport of the internalised Wnt chaperone Wntless. Here the authors show that in both C. elegans and human cells, SNX3-retromer requires an evo
Externí odkaz:
https://doaj.org/article/d470221d33d847238609773f477f4c71
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100560-(2021)
STAR Protocols
STAR Protocols
Summary This one-step method generates, for any locus, a conditional knockout allele in Drosophila. The allele carries a bright fluorescent marker for easy screening and an attP landing site for subsequent genetic manipulations. After removing the se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230c407ff9b2db32922e08edc30c496d
http://www.sciencedirect.com/science/article/pii/S2666166721002677
http://www.sciencedirect.com/science/article/pii/S2666166721002677
Autor:
Ian J. McGough, Jean-Paul Vincent
Publikováno v:
Developmental Cell
Adenomatous polyposis coli (APC) mutations cause Wnt pathway activation in human cancers. Current models for APC action emphasize its role in promoting β-catenin degradation downstream of Wnt receptors. Unexpectedly, we find that blocking Wnt recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5202249a73358f1e9c98bad2772f5552
Autor:
Jean-Paul Vincent, Dhira Joshi, Christian Siebold, Tomas Malinauskas, B. Bishop, Nicola O’Reilly, E. Yvonne Jones, L. Vecchia, Ian J. McGough, Karen Beckett
Publikováno v:
Nature
A relatively small number of proteins have been suggested to act as morphogens—signalling molecules that spread within tissues to organize tissue repair and the specification of cell fate during development. Among them are Wnt proteins, which carry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8076d30b5800189ddc77588b04bc99f8
https://doi.org/10.1038/s41586-020-2498-z
https://doi.org/10.1038/s41586-020-2498-z
Autor:
Joyce J.S. Yu, Cyrille Alexandre, Ian J. McGough, Jean-Paul Vincent, Yohanns Bellaïche, Aude Maugarny-Calès, Stéphane Pelletier
SummaryPlanar cell polarity (PCP) organizes the orientation of cellular protrusions and migratory activity within the tissue plane. PCP establishment involves the subcellular polarization of core PCP components. It has been suggested Wnt gradients co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ab371f36f3070a83550f88755a840a3
https://doi.org/10.1101/2020.05.23.108977
https://doi.org/10.1101/2020.05.23.108977
Autor:
Aude Maugarny-Calès, Ian J. McGough, Joyce J.S. Yu, Cyrille Alexandre, Jean-Paul Vincent, Stéphane Pelletier, Yohanns Bellaïche
Publikováno v:
Developmental Cell
Summary Planar cell polarity (PCP) organizes the orientation of cellular protrusions and migratory activity within the tissue plane. PCP establishment involves the subcellular polarization of core PCP components. It has been suggested that Wnt gradie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ba92eeb96883539a59ac0b355cacb6
https://doi.org/10.1016/j.devcel.2020.08.004
https://doi.org/10.1016/j.devcel.2020.08.004
Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins
Autor:
Frances C. Tilley, Chris M. Danson, Peter J. Cullen, Kate J. Heesom, Ian J. McGough, Adam P. Jellett, Matthew Gallon, Kirsty J McMillan, Kevin A. Wilkinson, Brett M. Collins, Thomas Clairfeuille
Publikováno v:
The Journal of Cell Biology
McMillan, K J, Gallon, M J, Jellett, A P, Clairfeuille, T, Tilley, F C, McGough, I, Danson, C M, Heesom, K J, Wilkinson, K A, Collins, B M & Cullen, P J 2016, ' Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins ', Journal of Cell Biology, vol. 214, no. 4, pp. 389-399 . https://doi.org/10.1083/jcb.201604057
McMillan, K J, Gallon, M J, Jellett, A P, Clairfeuille, T, Tilley, F C, McGough, I, Danson, C M, Heesom, K J, Wilkinson, K A, Collins, B M & Cullen, P J 2016, ' Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins ', Journal of Cell Biology, vol. 214, no. 4, pp. 389-399 . https://doi.org/10.1083/jcb.201604057
Mutations in the retromer complex, which is involved in sorting integral membrane proteins from endosomes to cellular compartments, are associated with atypical parkinsonism, but how these mutations affect retromer function remains unclear. Through a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b5af66b2a4b1670ed564702aff1852
https://pubmed.ncbi.nlm.nih.gov/27528657
https://pubmed.ncbi.nlm.nih.gov/27528657
Publikováno v:
Journal of Cell Science
A key step in the canonical Wnt signalling pathway is the inhibition of GSK3β, which results in the accumulation of nuclear β-catenin (also known as CTNNB1), and hence regulation of target genes. Evidence suggests that endocytosis is required for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4e1af0875530c8515b21a64a839821
https://pubmed.ncbi.nlm.nih.gov/25236598
https://pubmed.ncbi.nlm.nih.gov/25236598
Autor:
Ian J. McGough, Peter A. Barbuti, Peter J. Cullen, Da Jia, Kirsty J McMillan, Alan L Whone, Daniel D. Billadeau, Michael K. Rosen, Maeve A. Caldwell, Kate J. Heesom, Florian Steinberg
Publikováno v:
McGough, I J, Steinberg, F, Jia, D, Barbuti, P A, McMillan, K J, Heesom, K J, Whone, A L, Caldwell, M A, Billadeau, D D, Rosen, M K & Cullen, P J 2014, ' Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation : Erratum ', Current Biology, vol. 24, no. 14, pp. 1678 . https://doi.org/10.1016/j.cub.2014.07.004
Current Biology
McGough, I J, Steinberg, F, Jia, D, Barbuti, P A, McMillan, K J, Heesom, K J, Whone, A L, Caldwell, M A, Billadeau, D D, Rosen, M K & Cullen, P J 2014, ' Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation ', Current Biology, vol. 24, no. 14, pp. 1670-1676 . https://doi.org/10.1016/j.cub.2014.06.024
Current Biology
McGough, I J, Steinberg, F, Jia, D, Barbuti, P A, McMillan, K J, Heesom, K J, Whone, A L, Caldwell, M A, Billadeau, D D, Rosen, M K & Cullen, P J 2014, ' Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation ', Current Biology, vol. 24, no. 14, pp. 1670-1676 . https://doi.org/10.1016/j.cub.2014.06.024
Summary Retromer is a protein assembly that plays a central role in orchestrating export of transmembrane-spanning cargo proteins from endosomes into retrieval pathways destined for the Golgi apparatus and the plasma membrane [1]. Recently, a specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34deb538edc7a3efbb60ef2eddff1285
https://research-information.bris.ac.uk/ws/files/210840700/1_s2.0_S0960982214008306_main.pdf
https://research-information.bris.ac.uk/ws/files/210840700/1_s2.0_S0960982214008306_main.pdf