Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Ian J Russell"'
Publikováno v:
Drug Delivery, Vol 28, Iss 1, Pp 1312-1320 (2021)
The cochlea’s inaccessibility and complex nature provide significant challenges to delivering drugs and other agents uniformly, safely and efficiently, along the entire cochlear spiral. Large drug concentration gradients are formed along the cochle
Externí odkaz:
https://doaj.org/article/1f218d8af4c44c4d91286dc711ed77f8
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: The mammalian cochlea is one of the least accessible organs for drug delivery. Systemic administration of many drugs is severely limited by the blood-labyrinth barrier. Local intratympanic administration into the middle ear would be a prefer
Externí odkaz:
https://doaj.org/article/0abe6bf0af2949148a7de12d2ce74bce
Autor:
Yukako Asai, Bifeng Pan, Carl Nist-Lund, Alice Galvin, Andrei N. Lukashkin, Victoria A. Lukashkina, Tianwen Chen, Wu Zhou, Hong Zhu, Ian J. Russell, Jeffrey R. Holt, Gwenaelle S. G. Géléoc
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Recent work has demonstrated that transmembrane channel-like 1 protein (TMC1) is an essential component of the sensory transduction complex in hair cells of the inner ear. A closely related homolog, TMC2, is expressed transiently in the neon
Externí odkaz:
https://doaj.org/article/7060bb4179c3426d8a8e22cd46477d42
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The sharp frequency tuning and exquisite sensitivity of the mammalian cochlea is due to active forces delivered by outer hair cells (OHCs) to the cochlear partition. Force transmission is mediated and modulated by specialized cells, includin
Externí odkaz:
https://doaj.org/article/d05a16c138454ed4b1706eae3d823603
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
A point mutation in the gap-junction protein connexin 30 stops early onset age-related hearing loss. Here, the authors show that gap junctions contribute to cochlear micromechanics and that cochlear amplification is likely controlled by extracellular
Externí odkaz:
https://doaj.org/article/db9279e8479c4eafbe4a3235a3fa6f72
Autor:
Ildar I. Sadreev, George W. S. Burwood, Samuel M. Flaherty, Jongrae Kim, Ian J. Russell, Timur I. Abdullin, Andrei N. Lukashkin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Intratympanic drug administration depends on the ability of drugs to pass through the round window membrane (RW) at the base of the cochlea and diffuse from this location to the apex. While the RW permeability for many different drugs can be promoted
Externí odkaz:
https://doaj.org/article/1a8da5bc61c04d36a676d95ca534bdf0
SUMMARYSensory hair cells, including the sensorimotor outer hair cells, which enable the sensitive, sharply tuned responses of the mammalian cochlea, are excited by radial shear between the organ of Corti and the overlying tectorial membrane. It is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c1f5610f9d7fb41d25ad94caff486bb
https://doi.org/10.1101/2023.02.24.529908
https://doi.org/10.1101/2023.02.24.529908
Publikováno v:
Journal of The Royal Society Interface. 19
Male mosquitoes detect and localize conspecific females by their flight-tones using the Johnston's organ (JO), which detects antennal deflections under the influence of local particle motion. Acoustic behaviours of mosquitoes and their JO physiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0d3bec5c64636cc30dae1b22e61e38
https://doi.org/10.1098/rsif.2022.0285
https://doi.org/10.1098/rsif.2022.0285
Autor:
Victoria A. Lukashkina, Snezana Levic, Patrício Simões, Zhenhang Xu, Joseph A. DiGuiseppi, Jian Zuo, Andrei N. Lukashin, Ian J. Russell
Publikováno v:
J Neurosci
Cochlear sensitivity, essential for communication and exploiting the acoustic environment, results from sensory-motor outer hair cells (OHCs) operating in a structural scaffold of supporting cells and extracellular cortilymph within the organ of Cort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f71bf8631e400aa9d74170306fed487
https://europepmc.org/articles/PMC9302466/
https://europepmc.org/articles/PMC9302466/
Autor:
Jorn A. Cheney, Ian J. Russell, Simon M. Walker, Richard J. Bomphrey, Patricio Simoes, Nathan Phillips, Toshiyuki Nakata
Publikováno v:
Science. 368:634-637
Sensing surfaces like a mosquito Although sonar or lidar are used by autonomous vehicles to detect nearby objects, these approaches incur significant equipment and signal-processing costs. Nakata et al. show that mosquitos detect surfaces using the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd44fe2d982299f63a1e39b809c8fa3
https://doi.org/10.1126/science.aaz9634
https://doi.org/10.1126/science.aaz9634