Zobrazeno 1 - 10
of 326
pro vyhledávání: '"Ian J, Stratford"'
Autor:
Alice Spadea, Annalisa Tirella, Julio Manuel Rios de la Rosa, Enrique Lallana, Manal Mehibel, Brian Telfer, Nicola Tirelli, Margaret Jayne Lawrence, Kaye J. Williams, Ian J. Stratford, Marianne Ashford
Publikováno v:
Pharmaceutics, Vol 16, Iss 10, p 1286 (2024)
Background/Objectives: Conventional anticancer therapies often lack specificity, targeting both cancerous and normal cells, which reduces efficacy and leads to undesired off-target effects. An additional challenge is the presence of hypoxic regions i
Externí odkaz:
https://doaj.org/article/a3b8c5c8ac114761af6bae85f5b0e888
Autor:
Emma J Searle, Brian A Telfer, Debayan Mukherjee, Duncan M Forster, Barry R Davies, Kaye J Williams, Ian J Stratford, Tim M Illidge
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 12, Pp 1646-1659 (2017)
Abstract Radiotherapy is an important anti‐cancer treatment, but tumour recurrence remains a significant clinical problem. In an effort to improve outcomes further, targeted anti‐cancer drugs are being tested in combination with radiotherapy. Her
Externí odkaz:
https://doaj.org/article/94b34dde6bcb4bbb88dfef6a2ecc2928
Autor:
Ian J. Stratford, Susan E. Critchlow, Paul D. Smith, Kaye J. Williams, Brian A. Telfer, Kathryn G. Blount, Filippos Michopoulos, Amy L. Chadwick, Becky M. Bola
This file shows a hierarchical analysis of individual metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caccfdfe21bc334f6c619f5005fa840c
https://doi.org/10.1158/1535-7163.22502382.v1
https://doi.org/10.1158/1535-7163.22502382.v1
Autor:
Ian J. Stratford, Susan E. Critchlow, Paul D. Smith, Kaye J. Williams, Brian A. Telfer, Kathryn G. Blount, Filippos Michopoulos, Amy L. Chadwick, Becky M. Bola
This file contains details of the reaction conditions for determining glycolytic isoenzyme kinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861d497f3b7aeaf99880a4a514b651cb
https://doi.org/10.1158/1535-7163.22502358
https://doi.org/10.1158/1535-7163.22502358
Autor:
Ian J. Stratford, David Leys, Katherine A. Scott, Mary C. Caraher, Mark S. Dunstan, Karen A. Nolan
The National Cancer Institute chemical database has been screened using in silico docking to identify novel nanomolar inhibitors of NRH:quinone oxidoreductase 2 (NQO2). The inhibitors identified from the screen exhibit a diverse range of scaffolds an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0795f7e8755ff509725dbaeeab6bba29
https://doi.org/10.1158/1535-7163.c.6535672
https://doi.org/10.1158/1535-7163.c.6535672
Autor:
Ian J. Stratford, Susan E. Critchlow, Paul D. Smith, Kaye J. Williams, Brian A. Telfer, Kathryn G. Blount, Filippos Michopoulos, Amy L. Chadwick, Becky M. Bola
This file shows the aerobic and anoxic toxicity of AZD3965.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2310b6caa33dbfec3004ae7b7846fb5c
https://doi.org/10.1158/1535-7163.22502373.v1
https://doi.org/10.1158/1535-7163.22502373.v1
Autor:
Ian J. Stratford, Susan E. Critchlow, Paul D. Smith, Kaye J. Williams, Brian A. Telfer, Kathryn G. Blount, Filippos Michopoulos, Amy L. Chadwick, Becky M. Bola
This file shows IHC slides of H526 tumors taken from mice treated with or without AZD3965 and stained for MCT4 or CD31 expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239bf5d52582a77f81fb409e543bc529
https://doi.org/10.1158/1535-7163.22502370
https://doi.org/10.1158/1535-7163.22502370
Autor:
Ian J. Stratford, Susan E. Critchlow, Paul D. Smith, Kaye J. Williams, Brian A. Telfer, Kathryn G. Blount, Filippos Michopoulos, Amy L. Chadwick, Becky M. Bola
This file shows a comparison of the effect of hypoxia on metabolite profiles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b0e7b4e7dabfec98f78cad9d65f05f
https://doi.org/10.1158/1535-7163.22502379.v1
https://doi.org/10.1158/1535-7163.22502379.v1
Autor:
Ian J. Stratford, Susan E. Critchlow, Paul D. Smith, Kaye J. Williams, Brian A. Telfer, Kathryn G. Blount, Filippos Michopoulos, Amy L. Chadwick, Becky M. Bola
This file shows that Inhibition of lactate transport by AZD3965 can cause oxidative stress.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0487854c73c0493293b42e70a2fb6289
https://doi.org/10.1158/1535-7163.22502376
https://doi.org/10.1158/1535-7163.22502376