Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Ian J, Holt"'
Autor:
Irati Aiestaran-Zelaia, María Jesús Sánchez-Guisado, Marina Villar-Fernandez, Mikel Azkargorta, Lucia Fadon-Padilla, Uxoa Fernandez-Pelayo, Diego Perez-Rodriguez, Pedro Ramos-Cabrer, Antonella Spinazzola, Félix Elortza, Jésus Ruíz-Cabello, Ian J. Holt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract 2-Deoxy-D-glucose (2DG) has recently received emergency approval for the treatment of COVID-19 in India, after a successful clinical trial. SARS-CoV-2 infection of cultured cells is accompanied by elevated glycolysis and decreased mitochondr
Externí odkaz:
https://doaj.org/article/ae1a24df2d814342a7c743fdb2f02584
Autor:
Boris Pantic, Daniel Ives, Mara Mennuni, Diego Perez-Rodriguez, Uxoa Fernandez-Pelayo, Amaia Lopez de Arbina, Mikel Muñoz-Oreja, Marina Villar-Fernandez, Thanh-mai Julie Dang, Lodovica Vergani, Iain G. Johnston, Robert D. S. Pitceathly, Robert McFarland, Michael G. Hanna, Robert W. Taylor, Ian J. Holt, Antonella Spinazzola
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
It has been a longstanding goal to promote the propagation of functional mitochondrial DNAs at the expense of pathological molecules in cells where the two species coexist. Here, the authors show that restricting the availability of glucose and gluta
Externí odkaz:
https://doaj.org/article/ddb6e0fbdcc044759f368cb2f07e6239
Autor:
Romina Durigon, Alice L Mitchell, Aleck WE Jones, Andreea Manole, Mara Mennuni, Elizabeth MA Hirst, Henry Houlden, Giuseppe Maragni, Serena Lattante, Paolo Niccolo’ Doronzio, Ilaria Dalla Rosa, Marcella Zollino, Ian J Holt, Antonella Spinazzola
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-20 (2018)
Abstract The diverse clinical phenotypes of Wolf–Hirschhorn syndrome (WHS) are the result of haploinsufficiency of several genes, one of which, LETM1, encodes a protein of the mitochondrial inner membrane of uncertain function. Here, we show that L
Externí odkaz:
https://doaj.org/article/1e9b97c05f204f27bc09bdacc3041823
Autor:
Ian J, Holt
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2528
R-loops forming inadvertently during transcription can threaten genome stability, but R-loops are also formed intentionally, as a means of regulating transcription and other aspects of DNA metabolism. The study of R-loops in mitochondria is in its in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c33637a1e912c394e0c0a94bfe67c803
https://pubmed.ncbi.nlm.nih.gov/35704192
https://pubmed.ncbi.nlm.nih.gov/35704192
Autor:
Enrico Bugiardini, Alan M. Pittman, Conceição Bettencourt, C Woodward, Henry Houlden, Alejandro Horga, Antonella Spinazzola, Ilaria Dalla Rosa, Iain P. Hargreaves, Langping He, Emma L. Blakely, Michael G. Hanna, Sachit Shah, Andreea Manole, Alice L Mitchell, Robert W. Taylor, Robert D S Pitceathly, James M. Polke, Ian J Holt, Mary M. Reilly, Walied Mowafi, Ros Quinlivan
Publikováno v:
Molecular Biology Reports. 48:2093-2104
Mutations in nuclear-encoded protein subunits of the mitochondrial ribosome are an increasingly recognised cause of oxidative phosphorylation system (OXPHOS) disorders. Among them, mutations in the MRPL44 gene, encoding a structural protein of the la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a62207667a5b17ffd1f7fbb71ad1e3c
https://doi.org/10.1007/s11033-021-06188-1
https://doi.org/10.1007/s11033-021-06188-1
Autor:
Ilaria Dalla Rosa, Yolanda Cámara, Romina Durigon, Chloe F Moss, Sara Vidoni, Gokhan Akman, Lilian Hunt, Mark A Johnson, Sarah Grocott, Liya Wang, David R Thorburn, Michio Hirano, Joanna Poulton, Robert W Taylor, Greg Elgar, Ramon Martí, Peter Voshol, Ian J Holt, Antonella Spinazzola
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005779 (2016)
MPV17 is a mitochondrial inner membrane protein whose dysfunction causes mitochondrial DNA abnormalities and disease by an unknown mechanism. Perturbations of deoxynucleoside triphosphate (dNTP) pools are a recognized cause of mitochondrial genomic i
Externí odkaz:
https://doaj.org/article/fd0c8fb28a5f40f98a92dee74e9682c6
Publikováno v:
Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases ISBN: 9783030677268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be52b031b21354363ff80edad3769b30
https://doi.org/10.1007/978-3-030-67727-5_45
https://doi.org/10.1007/978-3-030-67727-5_45
Autor:
Mikel Muñoz Oreja, Antonella Spinazzolla, Romina Durigon, Adam C. Gunning, Uxoa Fernandez Pelayo, Ian J Holt, Sian Ellard
Publikováno v:
IV. Ikergazte. Nazioarteko ikerketa euskaraz. Kongresuko artikulu bilduma. Zientziak eta Natura Zientzia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad4bb3a9a3ddd97d01a380d7c7292362
https://doi.org/10.26876/ikergazte.iv.05.36
https://doi.org/10.26876/ikergazte.iv.05.36
Autor:
Ian J Holt
Publikováno v:
Nucleic Acids Research
The DNA in mitochondria contributes essential components of the organelle’s energy producing machinery that is essential for life. In 1971, many mitochondrial DNA molecules were found to have a third strand of DNA that maps to a region containing c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea5372af33228519ea66d4ba1785520
https://doi.org/10.1093/nar/gkz277
https://doi.org/10.1093/nar/gkz277
Autor:
Mark A Johnson, Sara Vidoni, Romina Durigon, Sarah F Pearce, Joanna Rorbach, Jiuya He, Gloria Brea-Calvo, Michal Minczuk, Aurelio Reyes, Ian J Holt, Antonella Spinazzola
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93597 (2014)
Amino acids are essential for cell growth and proliferation for they can serve as precursors of protein synthesis, be remodelled for nucleotide and fat biosynthesis, or be burnt as fuel. Mitochondria are energy producing organelles that additionally
Externí odkaz:
https://doaj.org/article/060d119681d2428da9e75e0ee7923308