Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Ian Hutchinson"'
Autor:
Carter M. Lindborg, Richard D. Smith, Alec M. Reihl, Blake M. Bacevich, Mark Cote, Evan O’Donnell, Augustus D. Mazzocca, Ian Hutchinson
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 5, p 1413 (2024)
Background: The management of acromioclavicular joint injuries requires a thorough understanding of the anatomy and biomechanics of the joint, as well as knowledge of the pertinent physical exam findings and classification to determine an appropriate
Externí odkaz:
https://doaj.org/article/1bc87aa62cdb41729fa88b0de1529ab8
Publikováno v:
North American Spine Society Journal, Vol 6, Iss , Pp 100067- (2021)
Background: Spinal epidural abscess (SEA) in children is a rare condition with dangerous sequelae, and with only 22 other cases reported in the literature, treatment algorithms are poorly understood. Quick identification of the classic tried of sepsi
Externí odkaz:
https://doaj.org/article/b1a8d4b41cc04e968f38ff537695a2df
Autor:
Abbas Shirdel, Mahmoud Reza Azarpazhooh, Maryam Sahebari, Mohsen Ghanbari, Seyedeh Zahra Mirfeizi, Ian Hutchinson, Aghigh Ziaee, Houshang Rafatpanah
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 16, Iss 3, Pp 258-263 (2013)
The underlying mechanisms leading to the development of human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic factors appear
Externí odkaz:
https://doaj.org/article/428d676321f248ad87749f80e9af6236
Autor:
Ian Hutchinson
Plasma physicist Ian Hutchinson has been asked hundreds of questions about faith and science:What is faith and what is science? Are they compatible? Are there realities science cannot explain? Is God's existence a scientific question? Is the Bible co
Publikováno v:
American Antiquity. 88:62-78
Radiocarbon dates on marine shell and other materials of marine origin appear significantly older than contemporaneous samples of terrestrial/atmospheric origin. Misunderstandings regarding the mechanisms that give rise to this “marine reservoir ef
Autor:
Philip W. Howard, John A. Hartley, Mary McFarlane, Luke A. Masterson, Kathryn Ball, Conor S. Barry, Lauren Adams, Rhiannon Beard, K. Phin Chooi, Gyoung-Dong Kang, Ian Hutchinson, Jitka Riedl, Kathleen Santos, Balakumar Vijayakrishnan, Shameen Afif-Rider, Neki Patel, Kathryn Pugh, Stephen J. Gregson
Supplementary Data from Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody–Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0808e71ffb8fdea67b4acfbd119e387a
https://doi.org/10.1158/1535-7163.22523461.v1
https://doi.org/10.1158/1535-7163.22523461.v1
Autor:
Puja Sapra, Nadia Luheshi, Philip W. Howard, David A. Tice, Anna D. Staniszewska, Mark R. Albertella, Elisabetta Leo, Yann Wallez, Frances Anne Tosto, Darrin Sabol, R. James Christie, Nazzareno Dimasi, Jixin Wang, Steven Novick, Noel Monks, Judith Anderton, Jon Chesebrough, Jiaqi Yuan, Anton I. Rosenbaum, Yue Huang, Arthur Lewis, Michael Davies, Kathryn Ball, Mary McFarlane, Balakumar Vijayakrishnan, Ian Hutchinson, Thais Cailleau, Luke Masterson, Niall J. Dickinson, Zachary A. Cooper, Philipp Wortmann, Krista Kinneer
Supplementary Figure S1. Analytical characterization of INT016-ADCs; Supplementary Figure S2. Validation of B7-H4 antibodies for use in IHC; Supplementary Figure S3. Relationship between B7-H4 expression level and heterogeneity in the studied human t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0600301b9082af559c2fa9c3e42833d8
https://doi.org/10.1158/1078-0432.22490063.v1
https://doi.org/10.1158/1078-0432.22490063.v1
Autor:
Puja Sapra, Nadia Luheshi, Philip W. Howard, David A. Tice, Anna D. Staniszewska, Mark R. Albertella, Elisabetta Leo, Yann Wallez, Frances Anne Tosto, Darrin Sabol, R. James Christie, Nazzareno Dimasi, Jixin Wang, Steven Novick, Noel Monks, Judith Anderton, Jon Chesebrough, Jiaqi Yuan, Anton I. Rosenbaum, Yue Huang, Arthur Lewis, Michael Davies, Kathryn Ball, Mary McFarlane, Balakumar Vijayakrishnan, Ian Hutchinson, Thais Cailleau, Luke Masterson, Niall J. Dickinson, Zachary A. Cooper, Philipp Wortmann, Krista Kinneer
Surface plasmon resonance; In vitro cytotoxicity assays; In vitro proliferation assays; Internalization assays; Subcellular localization microscopy; Immunoblotting; Statistical analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58213ceddc604034835e98180a6978da
https://doi.org/10.1158/1078-0432.22490054
https://doi.org/10.1158/1078-0432.22490054
Autor:
Puja Sapra, Nadia Luheshi, Philip W. Howard, David A. Tice, Anna D. Staniszewska, Mark R. Albertella, Elisabetta Leo, Yann Wallez, Frances Anne Tosto, Darrin Sabol, R. James Christie, Nazzareno Dimasi, Jixin Wang, Steven Novick, Noel Monks, Judith Anderton, Jon Chesebrough, Jiaqi Yuan, Anton I. Rosenbaum, Yue Huang, Arthur Lewis, Michael Davies, Kathryn Ball, Mary McFarlane, Balakumar Vijayakrishnan, Ian Hutchinson, Thais Cailleau, Luke Masterson, Niall J. Dickinson, Zachary A. Cooper, Philipp Wortmann, Krista Kinneer
Supplementary Table S1. Primary antibodies used for immunoblotting; Supplementary Table S2. Characterization of ADCs evaluated in this study; Supplementary Table S3. B7-H4 expression in human normal tissue; Supplementary Table S4. Binding affinity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca0fd579622b6cd057eabe5480be78a
https://doi.org/10.1158/1078-0432.22490048.v1
https://doi.org/10.1158/1078-0432.22490048.v1
Autor:
Puja Sapra, Nadia Luheshi, Philip W. Howard, David A. Tice, Anna D. Staniszewska, Mark R. Albertella, Elisabetta Leo, Yann Wallez, Frances Anne Tosto, Darrin Sabol, R. James Christie, Nazzareno Dimasi, Jixin Wang, Steven Novick, Noel Monks, Judith Anderton, Jon Chesebrough, Jiaqi Yuan, Anton I. Rosenbaum, Yue Huang, Arthur Lewis, Michael Davies, Kathryn Ball, Mary McFarlane, Balakumar Vijayakrishnan, Ian Hutchinson, Thais Cailleau, Luke Masterson, Niall J. Dickinson, Zachary A. Cooper, Philipp Wortmann, Krista Kinneer
Purpose:We evaluated the activity of AZD8205, a B7-H4–directed antibody–drug conjugate (ADC) bearing a novel topoisomerase I inhibitor (TOP1i) payload, alone and in combination with the PARP1-selective inhibitor AZD5305, in preclinical models.Exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87fea82a590d54f5004536e9439e672
https://doi.org/10.1158/1078-0432.c.6533087
https://doi.org/10.1158/1078-0432.c.6533087