Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ian Hiles"'
Publikováno v:
Biotechnology Letters. 43:757-765
To compare the effects of human Trypsin-1 signal peptide and pro-peptide on the expression and secretion efficiency of human Interleukin-25 from mammalian cells. The signal peptide and combined signal peptide-pro-peptide sequence of human Trypsin-1 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d207e8152fc24a2a5dd690f90f61fc
https://doi.org/10.1007/s10529-020-03072-z
https://doi.org/10.1007/s10529-020-03072-z
Publikováno v:
Biotechnology letters. 43(4)
To compare the effects of human Trypsin-1 signal peptide and pro-peptide on the expression and secretion efficiency of human Interleukin-25 from mammalian cells.The signal peptide and combined signal peptide-pro-peptide sequence of human Trypsin-1 im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d232d9bde89b0bbf687280ba1ce4645e
https://pubmed.ncbi.nlm.nih.gov/33415569
https://pubmed.ncbi.nlm.nih.gov/33415569
Autor:
Martin J. Scott, Ian Hiles, Matthew S. Wake, Claire Ashman, Michael Steward, Trevor Anthony Kenneth Wattam, Thil D. Batuwangala, Kelly V. Batt, Jennifer A. Lee
Publikováno v:
mAbs. 9:85-93
Bispecific antibodies (BsAbs) are emerging as an important class of biopharmaceutical. The majority of BsAbs are created from conventional antibodies or fragments engineered into more complex configurations. A recurring challenge in their development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b6491eef1f05a39fb558763a8d1e33
https://doi.org/10.1080/19420862.2016.1249078
https://doi.org/10.1080/19420862.2016.1249078
Autor:
Wilhelm J. Schwaeble, Richard A. G. Smith, Anna Buchberger, Julia Smith, Peter J. Lachmann, Sarah Nutland, Ian Hiles, Elizabeth Lay, David J. Seilly
Publikováno v:
Clinical and Experimental Immunology. 181:314-322
Summary Sera from a large panel of normal subjects were typed for three common polymorphisms, one in C3 (R102G) and two in Factor H (V62I and Y402H), that influence predisposition to age-related macular degeneration and to some forms of kidney diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d5d36fd38f12cba0c2ce238c53cdf3
https://doi.org/10.1111/cei.12437
https://doi.org/10.1111/cei.12437
Autor:
George Panayotou, Serge Roche, P Vicendo, Michael J. Fry, Ritu Dhand, Nick Totty, Ivan Gout, Ian Hiles, K. Yonezawa, Oanh Truong
Publikováno v:
The EMBO Journal. 13:522-533
Phosphatidylinositol 3-kinase (PI 3-kinase) has a regulatory 85 kDa adaptor subunit whose SH2 domains bind phosphotyrosine in specific recognition motifs, and a catalytic 110 kDa subunit. Mutagenesis of the p110 subunit, within a sequence motif commo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717eda3b305db5cf9d20ef53c1b64af2
https://doi.org/10.1002/j.1460-2075.1994.tb06290.x
https://doi.org/10.1002/j.1460-2075.1994.tb06290.x
Autor:
Michael J. Fry, Iain D. Campbell, Oanh Truong, Ian Hiles, Nicholas F. Totty, George Panayotou, Ivan Gout, Michael D. Waterfield, J. Justin Hsuan, Ritu Dhand, Grant W. Booker, Pamela Das
Publikováno v:
Cell. 75:25-36
Summary Src homology 3 (SH3) domains have been implicated in mediating protein-protein interactions in receptor signaling processes; however, the precise role of this domain remains unclear. In this report, affinity purification techniques were used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8da96c91a8a75f91fd5eeea3edddbed5
https://doi.org/10.1016/s0092-8674(05)80081-9
https://doi.org/10.1016/s0092-8674(05)80081-9
Autor:
Sara A. Courtneidge, Nicholas F. Totty, Fernanda Ruiz-Larrea, Andrew J. Thompson, Ian Hiles, Stefano Volinia, Ritu Dhand, George Panayotou, J. Justin Hsuan, Peter J. Parker, Michael D. Waterfield, Ivan Gout, Masayuki Otsu, Michael J. Fry
Publikováno v:
Cell. 70:419-429
Purified bovine brain phosphatidylinositol 3-kinase (Pl3-kinase) is composed of 85 kd and 110 kd subunits. The 85 kd subunit (p85 alpha) lacks Pl3-kinase activity and acts as an adaptor, coupling the 110 kd subunit (p110) to activated protein tyrosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d8efadf704ae508a5d5d367a704f77
https://doi.org/10.1016/0092-8674(92)90166-a
https://doi.org/10.1016/0092-8674(92)90166-a
Publikováno v:
Current biology : CB. 5(7)
Background: Phosphatidylinositol transfer protein (PI-TP), which has the ability to transfer phosphatidylinositol (PI) from one membrane compartment to another, is required in the inositol lipid signalling pathway through phospholipase C– β (PLC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056747490aec9386b398755a0526e365
https://pubmed.ncbi.nlm.nih.gov/7583124
https://pubmed.ncbi.nlm.nih.gov/7583124
Autor:
Hara Kenta, George Panayotou, Michael J. Fry, Mike Waterfield, K. Yonezawa, Ritu Dhand, M. Kasuga, Benjamin D. Bax, Ivan Gout, Ian Hiles
Publikováno v:
Scopus-Elsevier
Phosphatidylinositol (PI) 3-kinase has an 85 kDa subunit (p85 alpha) which mediates its association with activated protein tyrosine kinase receptors through SH2 domains, and an 110 kDa subunit (p110) which has intrinsic catalytic activity. Here p85 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1cc23b27527fafbfcf47d6ec782948
https://europepmc.org/articles/PMC394840/
https://europepmc.org/articles/PMC394840/
Autor:
Dean Nizetic, Michael O. Waterfield, Elizabeth Ormondroyd, Rachele Antonacci, Stefano Volinia, Ian Hiles, Mariano Rocchi
Phosphatidylinositol (PI) 3-kinase is a heterodimeric enzyme comprising a 110-kDa catalytic subunit and an 85-kDa regulatory subunit that binds to tyrosine phosphopeptide sites linked directly or indirectly to receptors serving diverse signal functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a31281d53eeae408026c9551e4d5e4
http://hdl.handle.net/11392/1690780
http://hdl.handle.net/11392/1690780