Integrin β1, Osmosensing, and Chemoresistance in Mouse Ehrlich Carcinoma Cells

Autor: Belinda Halling Sørensen, Line Jee Hartmann Rasmussen, Bjørn Sindballe Broberg, Thomas Kjær Klausen, Daniel Peter Rafael Sauter, Ian Henry Lambert, Anders Aspberg, Else Kay Hoffmann

Publikováno v: Cellular Physiology and Biochemistry, Vol 36, Iss 1, Pp 111-132 (2015)

Background/Aims: Altered expression of the integrin family of cell adhesion receptors has been associated with initiation, progression, and metastasis of solid tumors as well as in the development of chemoresistance. Here, we investigated the role of

Externí odkaz: https://doaj.org/article/8329f77e72384517abf9756bd934a2b5

Eicosanoids and Cell Volume Regulation

Autor: Ian Henry Lambert

Publikováno v: Cellular and Molecular Physiology of Cell Volume Regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1d3c5833a20ac1f25885a751b227fb5
https://doi.org/10.1201/9780367812140-19

Development and validation of an ICP-MS method for quantification of total carbon and platinum in cell samples and comparison of open-vessel and microwave-assisted acid digestion methods

Autor: Ian Henry Lambert, Mie Riisom, Stefan Stürup, Bente Gammelgaard

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 158:144-150

Cisplatin is a widely used chemotherapeutic drug. Due to severe side effects and intrinsic or acquired resistance, there is a great interest in developing new platinum-based anticancer agents and a need for robust and validated analytical methods for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4959edea86bb0195d68a267a33763a8
https://doi.org/10.1016/j.jpba.2018.05.038

MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism

Autor: Astrid L. Basse, Marie S. Isidor, Ian Henry Lambert, Mette D. Nielsen, Jacob B. Hansen, B. Viuff, Lasse K. Markussen, Elise S. Andersen, Charlotte Møller Petersen, Stine F. Pedersen

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Petersen, C, Nielsen, M D, Andersen, E S, Basse, A L, Isidor, M S, Markussen, L K, Viuff, B M, Lambert, I H, Hansen, J B & Pedersen, S H F 2017, ' MCT1 and MCT4 expression and lactate flux activity increase during white and brown adipogenesis and impact adipocyte metabolism ', Scientific Reports, vol. 7, no. 1, 13101 . https://doi.org/10.1038/s41598-017-13298-z

Adipose tissue takes up glucose and releases lactate, thereby contributing significantly to systemic glucose and lactate homeostasis. This implies the necessity of upregulation of net acid and lactate flux capacity during adipocyte differentiation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa0f4f2bccd6a17c3667385ca5e2aaf
https://doaj.org/article/8bf3e0267a624fd6a5bb3adcd9b1f5ba

Protolichesterinic Acid, Isolated from the LichenCetraria islandica, Reduces LRRC8A Expression and Volume-Sensitive Release of Organic Osmolytes in Human Lung Epithelial Cancer Cells

Autor: Ian Henry Lambert, Margret Thorsteinsdottir, Unnur Thorsteinsdottir

Publikováno v: Phytotherapy Research. 30:97-104

We have tested the effect of protolichesterinic acid (PA) on the activity of the volume-sensitive release pathway for the organic osmolyte taurine (VSOAC) and the expression of the leucine-rich-repeat-channel 8A (LRRC8A) protein, which constitutes an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::650ac225dc87cc28c730c1ccaf40469e
https://doi.org/10.1002/ptr.5507