Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ian Hammond-Martel"'
Autor:
Maïlyn Yates, Isabelle Marois, Edlie St-Hilaire, Daryl A Ronato, Billel Djerir, Chloé Brochu, Théo Morin, Ian Hammond-Martel, Sari Gezzar-Dandashi, Lisa Casimir, Elliot Drobetsky, Laurent Cappadocia, Jean-Yves Masson, Hugo Wurtele, Alexandre Maréchal
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002552 (2024)
Impediments in replication fork progression cause genomic instability, mutagenesis, and severe pathologies. At stalled forks, RPA-coated single-stranded DNA (ssDNA) activates the ATR kinase and directs fork remodeling, 2 key early events of the repli
Externí odkaz:
https://doaj.org/article/7a96143210c043db9c56e93cd5ee4106
Autor:
Abed El-Hakim El-Kadiry, Jamilah Abusarah, Yun Emma Cui, Nehme El-Hachem, Ian Hammond-Martel, Hugo Wurtele, Sini Thomas, Maryam Ahmadi, Mohammad Balood, Sébastien Talbot, Moutih Rafei
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Phenotypic screening is an ideal strategy for the discovery of novel bioactive molecules. Using a customized high-throughput screening (HTS) assay employing primary T lymphocytes, we screened a small library of 4,398 compounds with unknown biological
Externí odkaz:
https://doaj.org/article/26996bf7a38c453a815cdd4e44246a56
Autor:
Ian Hammond-Martel, Helen Pak, Helen Yu, Raphael Rouget, Andrew A Horwitz, Jeffrey D Parvin, Elliot A Drobetsky, El Bachir Affar
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14027 (2010)
The function of BRCA1 in response to ionizing radiation, which directly generates DNA double strand breaks, has been extensively characterized. However previous investigations have produced conflicting data on mutagens that initially induce other cla
Externí odkaz:
https://doaj.org/article/71ebaf2397b44b62b44bdde2c71e36cc
Autor:
Moutih Rafei, Borhane Annabi, Samaneh Kamyabiazar, Francois Mercier, Maja Jankovic, Jerry Pelletier, Francis Robert, Noël J.-M. Raynal, Annie Beaudry, Hugo Wurtele, Ian Hammond-Martel, Abed El-Hakim El-Kadiry, Nehme El-Hachem, Yun Cui, Jamilah Abusarah
We report the discovery, via a unique high-throughput screening strategy, of a novel bioactive anticancer compound: Thiol Alkylating Compound Inducing Massive Apoptosis (TACIMA)-218. We demonstrate that this molecule engenders apoptotic cell death in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8a046dc9f897f20569dcc72a69be4f
https://doi.org/10.1158/1535-7163.c.6542889
https://doi.org/10.1158/1535-7163.c.6542889
Autor:
Moutih Rafei, Borhane Annabi, Samaneh Kamyabiazar, Francois Mercier, Maja Jankovic, Jerry Pelletier, Francis Robert, Noël J.-M. Raynal, Annie Beaudry, Hugo Wurtele, Ian Hammond-Martel, Abed El-Hakim El-Kadiry, Nehme El-Hachem, Yun Cui, Jamilah Abusarah
Supplementary data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0944f56406fdb39605eacf1cde207526
https://doi.org/10.1158/1535-7163.22521048
https://doi.org/10.1158/1535-7163.22521048
Autor:
Nicole L Batenburg, Sofiane Y Mersaoui, John R Walker, Yan Coulombe, Ian Hammond-Martel, Hugo Wurtele, Jean-Yves Masson, Xu-Dong Zhu
Publikováno v:
Nucleic Acids Research
Cockayne syndrome group B (CSB) protein has been implicated in the repair of a variety of DNA lesions that induce replication stress. However, little is known about its role at stalled replication forks. Here, we report that CSB is recruited to stall
Autor:
Francois Mercier, Noël J.-M. Raynal, Borhane Annabi, Yun Cui, Jerry Pelletier, Hugo Wurtele, Francis Robert, Jamilah Abusarah, Nehme El-Hachem, Annie Beaudry, Maja Jankovic, Abed El-Hakim El-Kadiry, Moutih Rafei, Samaneh Kamyabiazar, Ian Hammond-Martel
Publikováno v:
Molecular Cancer Therapeutics. 20:37-49
We report the discovery, via a unique high-throughput screening strategy, of a novel bioactive anticancer compound: Thiol Alkylating Compound Inducing Massive Apoptosis (TACIMA)-218. We demonstrate that this molecule engenders apoptotic cell death in
Publikováno v:
DNA Repair. 104:103140
A broad spectrum of spontaneous and genotoxin-induced DNA lesions impede replication fork progression. The DNA damage response that acts to promote completion of DNA replication is associated with dynamic changes in chromatin structure that include t
Autor:
Antoine Simoneau, Martine Raymond, Hugo Wurtele, Guri Giaever, Lai Hong Wong, Sandra Weber, Corey Nislow, Étienne Ricard, Adnane Sellam, Ian Hammond-Martel
Publikováno v:
Nucleic Acids Research
The Saccharomyces cerevisiae genome encodes five sirtuins (Sir2 and Hst1–4), which constitute a conserved family of NAD-dependent histone deacetylases. Cells lacking any individual sirtuin display mild growth and gene silencing defects. However, hs
Autor:
Nicholas V G Iannantuono, Ian Hammond-Martel, Salima Daou, Michele Carbone, Eric Milot, Frédérick A. Mallette, Helen Pak, El Bachir Affar, Jessica Gagnon, Hugo Wurtele, Alena Motorina, Helen Yu, Nadine Sen Nkwe, Nazar Mashtalir, Haithem Barbour
Publikováno v:
Journal of Biological Chemistry. 290:28643-28663
The deubiquitinase (DUB) and tumor suppressor BAP1 catalyzes ubiquitin removal from histone H2A Lys-119 and coordinates cell proliferation, but how BAP1 partners modulate its function remains poorly understood. Here, we report that BAP1 forms two mut