Zobrazeno 1 - 10
of 400
pro vyhledávání: '"Ian H. de Boer"'
Autor:
Debora L. Gisch, Michelle Brennan, Blue B. Lake, Jeannine Basta, Mark S. Keller, Ricardo Melo Ferreira, Shreeram Akilesh, Reetika Ghag, Charles Lu, Ying-Hua Cheng, Kimberly S. Collins, Samir V. Parikh, Brad H. Rovin, Lynn Robbins, Lisa Stout, Kimberly Y. Conklin, Dinh Diep, Bo Zhang, Amanda Knoten, Daria Barwinska, Mahla Asghari, Angela R. Sabo, Michael J. Ferkowicz, Timothy A. Sutton, Katherine J. Kelly, Ian H. De Boer, Sylvia E. Rosas, Krzysztof Kiryluk, Jeffrey B. Hodgin, Fadhl Alakwaa, Seth Winfree, Nichole Jefferson, Aydın Türkmen, Joseph P. Gaut, Nils Gehlenborg, Carrie L. Phillips, Tarek M. El-Achkar, Pierre C. Dagher, Takashi Hato, Kun Zhang, Jonathan Himmelfarb, Matthias Kretzler, Shamim Mollah, the Kidney Precision Medicine Project (KPMP), Sanjay Jain, Michael Rauchman, Michael T. Eadon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract There is a need to define regions of gene activation or repression that control human kidney cells in states of health, injury, and repair to understand the molecular pathogenesis of kidney disease and design therapeutic strategies. Comprehe
Externí odkaz:
https://doaj.org/article/8d81e0f3c4d54dd6b9a6681fc0df894c
Autor:
Kumar Sharma, Guanshi Zhang, Jens Hansen, Petter Bjornstad, Hak Joo Lee, Rajasree Menon, Leila Hejazi, Jian-Jun Liu, Anthony Franzone, Helen C. Looker, Byeong Yeob Choi, Roman Fernandez, Manjeri A. Venkatachalam, Luxcia Kugathasan, Vikas S. Sridhar, Loki Natarajan, Jing Zhang, Varun S. Sharma, Brian Kwan, Sushrut S. Waikar, Jonathan Himmelfarb, Katherine R. Tuttle, Bryan Kestenbaum, Tobias Fuhrer, Harold I. Feldman, Ian H. de Boer, Fabio C. Tucci, John Sedor, Hiddo Lambers Heerspink, Jennifer Schaub, Edgar A. Otto, Jeffrey B. Hodgin, Matthias Kretzler, Christopher R. Anderton, Theodore Alexandrov, David Cherney, Su Chi Lim, Robert G. Nelson, Jonathan Gelfond, Ravi Iyengar, for the Kidney Precision Medicine Project
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
Diabetic kidney disease (DKD) can lead to end-stage kidney disease (ESKD) and mortality; however, few mechanistic biomarkers are available for high-risk patients, especially those without macroalbuminuria. Urine from participants with diabetes from t
Externí odkaz:
https://doaj.org/article/15a3cc7202a34114a72f51162fa19310
Autor:
Benjamin Lidgard, Andrew N. Hoofnagle, Leila R. Zelnick, Ian H. de Boer, Amanda M. Fretts, Bryan R. Kestenbaum, Rozenn N. Lemaitre, Cassianne Robinson-Cohen, Nisha Bansal
Publikováno v:
Kidney Medicine, Vol 5, Iss 10, Pp 100708- (2023)
Rationale & Objective: Patients with chronic kidney disease (CKD) have dysfunctional high-density lipoprotein (HDL) particles that lack cardioprotective properties; altered lipid composition may be associated with these changes. To investigate HDL li
Externí odkaz:
https://doaj.org/article/3e636049ad10448eb6a8103f981495ef
Autor:
Simon Hsu, Leila R. Zelnick, Nisha Bansal, Julia Brown, Michelle Denburg, Harold I. Feldman, Charles Ginsberg, Andrew N. Hoofnagle, Tamara Isakova, Mary B. Leonard, Benjamin Lidgard, Cassianne Robinson‐Cohen, Myles Wolf, Dawei Xie, Bryan R. Kestenbaum, Ian H. de Boer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 14 (2023)
Background The ratio of 24,25‐dihydroxyvitamin D3/25‐hydroxyvitamin D3 (vitamin D metabolite ratio [VDMR]) may reflect functional vitamin D activity. We examined associations of the VDMR, 25‐hydroxyvitamin D (25[OH]D), and 1,25‐dihydroxyvitam
Externí odkaz:
https://doaj.org/article/bd8c25897cb84c7387ea6d984c7971ad
Autor:
Armin Ahmadi, Gwenaelle Begue, Ana P. Valencia, Jennifer E. Norman, Benjamin Lidgard, Brian J. Bennett, Matthew P. Van Doren, David J. Marcinek, Sili Fan, David K. Prince, Jorge Gamboa, Jonathan Himmelfarb, Ian H. de Boer, Bryan R. Kestenbaum, Baback Roshanravan
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Background Current studies suggest mitochondrial dysfunction is a major contributor to impaired physical performance and exercise intolerance in chronic kidney disease (CKD). We conducted a clinical trial of coenzyme Q10 (CoQ10) and nicotinamide ribo
Externí odkaz:
https://doaj.org/article/152b024fbe374d49809a5ace393cfb86
Autor:
Nicole Evangelidis, Benedicte Sautenet, Magdalena Madero, Allison Tong, Gloria Ashuntantang, Laura Cortes Sanabria, Ian H. de Boer, Samuel Fung, Daniel Gallego, Andrew S. Levey, Adeera Levin, Eduardo Lorca, Ikechi G. Okpechi, Patrick Rossignol, Laura Sola, Tim Usherwood, David C. Wheeler, Yeoungjee Cho, Martin Howell, Chandana Guha, Nicole Scholes-Robertson, Katherine Widders, Andrea Matus Gonzalez, Armando Teixeira-Pinto, Andrea K. Viecelli, Amelie Bernier-Jean, Samaya Anumudu, Louese Dunn, Martin Wilkie, Jonathan C. Craig, on behalf of the SONG-CKD Investigators
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-8 (2021)
Abstract Background Globally, over 1.2 million people die from chronic kidney disease (CKD) every year. Patients with CKD are up to 10 times more likely to die prematurely than progress to kidney failure requiring kidney replacement therapy. The burd
Externí odkaz:
https://doaj.org/article/5c1520d43d134097835d130e24af59b3
Pulmonary surfactant protein B carried by HDL predicts incident CVD in patients with type 1 diabetes
Autor:
Baohai Shao, Janet K. Snell-Bergeon, Laura L. Pyle, Katie E. Thomas, Ian H. de Boer, Vishal Kothari, Jere Segrest, William S. Davidson, Karin E. Bornfeldt, Jay W. Heinecke
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 4, Pp 100196- (2022)
Atherosclerotic CVD is the major cause of death in patients with type 1 diabetes mellitus (T1DM). Alterations in the HDL proteome have been shown to associate with prevalent CVD in T1DM. We therefore sought to determine which proteins carried by HDL
Externí odkaz:
https://doaj.org/article/02a720eab7624a9ab69fbaae8aea3b24
Autor:
Michael Andrews, Teruhiko Yoshida, Clark M. Henderson, Hannah Pflaum, Ayako McGregor, Joshua A. Lieberman, Ian H. de Boer, Tomas Vaisar, Jonathan Himmelfarb, Bryan Kestenbaum, Joon-Yong Chung, Stephen M. Hewitt, Briana A. Santo, Brandon Ginley, Pinaki Sarder, Avi Z. Rosenberg, Taichi Murakami, Jeffrey B. Kopp, Zsuzsanna Kuklenyik, Andrew N. Hoofnagle
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Background Genetic variants in apolipoprotein L1 (APOL1), a protein that protects humans from infection with African trypanosomes, explain a substantial proportion of the excess risk of chronic kidney disease affecting individuals with sub-Saharan an
Externí odkaz:
https://doaj.org/article/6d32e5e3f318480f98a784dcc9bd072b
Autor:
Nisha Bansal, Ronit Katz, Lawrence Appel, Michelle Denburg, Harold Feldman, Alan S. Go, Jiang He, Andrew Hoofnagle, Tamara Isakova, Bryan Kestenbaum, John Kusek, James Lash, Mary Leonard, Mahboob Rahman, Cassianne Robinson-Cohen, Myles Wolf, Dawei Xie, Leila Zelnick, Ian H. de Boer, Lawrence J. Appel, Harold I. Feldman, John W. Kusek, James P. Lash, Panduranga S. Rao, Raymond R. Townsend
Publikováno v:
Kidney International Reports, Vol 4, Iss 11, Pp 1598-1607 (2019)
Introduction: Assessment of impaired vitamin D metabolism is limited by lack of functional measures. CYP24A1-mediated vitamin D clearance, calculated as the ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 (the vitamin D metabolic rat
Externí odkaz:
https://doaj.org/article/3c42234c185e4358b463713c610d329d
Autor:
Marius A. Øvrehus, Per Bruheim, Wenjun Ju, Leila R. Zelnick, Knut A. Langlo, Kumar Sharma, Ian H. de Boer, Stein I. Hallan
Publikováno v:
Kidney International Reports, Vol 4, Iss 2, Pp 321-333 (2019)
Introduction: Hypertensive nephrosclerosis is among the leading causes of end-stage renal disease, but its pathophysiology is poorly understood. We wanted to explore early metabolic changes using gene expression and targeted metabolomics analysis. Me
Externí odkaz:
https://doaj.org/article/829fecf27212450b8f0800e4927db5d0