Výsledky vyhledávání - "Ian H. Maxwell"

Parvovirus LuIII transducing vectors packaged by LuIII versus FPV capsid proteins: the VP1 N-terminal region is not a major determinant of human cell permissiveness

Autor: Francoise Maxwell, Ian H. Maxwell

Publikováno v: Journal of General Virology. 85:1251-1257

Human cell lines are permissive for LuIII, a member of the rodent group of autonomous parvoviruses. However, LuIII vectors pseudotyped with feline panleukopaenia virus (FPV) capsid proteins can transduce feline cells but not human cells. Feline trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d6cb5c570ac724a3bd6d0e0c3df4bf
https://doi.org/10.1099/vir.0.19490-0

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Autor: Françoise Maxwell, Ian H. Maxwell, Kurt Naujoks, Cortina Kaletta

Publikováno v: Angiogenesis. 6:31-38

Targeting the transcription of a toxin gene to activated endothelial cells might be used for inhibiting angiogenesis in solid tumors. As a model, we transiently transfected human endothelial cells (HUVEC) in culture with expression plasmids for the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdbce93d581406a8a81e7624c3725ad4
https://doi.org/10.1023/a:1025894616613

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Autonomous parvovirus vectors

Autor: Françoise Maxwell, Kristina L. Terrell, Ian H. Maxwell

Publikováno v: Methods. 28:168-181

Parvoviruses are small, icosahedral viruses (approximately 25 nm) containing a single-strand DNA genome (approximately 5 kb) with hairpin termini. Autonomous parvoviruses (APVs) are found in many species; they do not require a helper virus for replic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf973550da49b00cb9284de22a80aec
https://doi.org/10.1016/s1046-2023(02)00221-9

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Promoter Strength in Adenovirus Transducing Vectors: Down-Regulation of the Adenovirus E1A Promoter in 293 Cells Facilitates Vector Construction

Autor: David J. Orlicky, Blake Allen, Roderic L. Smith, Ian H. Maxwell, Jerome Schaack, Michael L. Bennett

Publikováno v: Virology. 291:101-109

Most adenovirus transducing vectors have the cytomegalovirus major immediate-early (CMV) or the Rous sarcoma virus long terminal repeat (RSV) promoter driving expression of the transgene. Both of these promoters are highly active in transfection and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29d94f69d338401b001695b0222e803
https://doi.org/10.1006/viro.2001.1211

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Expansion of tropism of a feline parvovirus to target a human tumor cell line by display of an αv integrin binding peptide on the capsid

Autor: J.T. Chapman, AL Spitzer, Sebastian Leptihn, Françoise Maxwell, Ian H. Maxwell, JA Corsini, L.C. Scherrer

Publikováno v: Gene Therapy. 8:324-331

The autonomous parvoviruses are small, non-enveloped, single strand DNA viruses. They occur in many species and they have oncolytic properties. We are modifying the capsid of feline panleukopenia virus (FPV), a parvovirus which normally infects felin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba06798affee41f2cc8ec446b54f831e
https://doi.org/10.1038/sj.gt.3301399

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Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells

Autor: Edward J. Dunphy, Rebecca A. Redman, Timothy P. Cripe, Frederic G. Barr, Edmond S. Massuda, Jennifer J. Schreiber, Ian H. Maxwell, Lauren E. Nauta

Publikováno v: Proceedings of the National Academy of Sciences. 94:14701-14706

Alveolar rhabdomyosarcoma (ARMS) cells often harbor one of two unique chromosomal translocations, either t(2;13)(q35;q14) or t(1;13)(p36;q14). The chimeric proteins expressed from these rearrangements, PAX3-FKHR and PAX7-FKHR, respectively, are poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4519ca9707d12d2b62a944d6c3c48b3f
https://doi.org/10.1073/pnas.94.26.14701

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Improved production of recombinant AAV by transient transfection of NB324K cells using electroporation

Autor: Gail S. Harrison, Ian H. Maxwell, Françoise Maxwell

Publikováno v: Journal of Virological Methods. 63:129-136

Adeno-associated virus (AAV) is useful as an integrating vector for gene transfer. AAV recombinants are generally produced by transient co-transfection methods since it has proven difficult to generate stable packaging cell lines. Acceptable titers o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0379ba5d7d4afd048b160555b2dc5fec
https://doi.org/10.1016/s0166-0934(96)02121-0

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Recombinant LuIII Autonomous Parvovirus as a Transient Transducing Vector for Human Cells

Autor: Jonathan O. Carlson, Françoise Maxwell, Solon L. Rhode, Ian H. Maxwell, Joe Corsini

Publikováno v: Human Gene Therapy. 4:441-450

Recombinants based on the genome of the autonomous parvovirus, LuIII, were constructed by replacing the viral coding sequences in an infectious clone (pGLu883) by a luciferase or beta-galactosidase reporter, which was linked to the viral P4 promoter.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a129fe9b88ddfc8f5b00914bbab879d7
https://doi.org/10.1089/hum.1993.4.4-441

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Expression of Diphtheria Toxin A-Chain in Mature B-Cells: A Potential Approach to Therapy of B-Lymphoid Malignancy

Autor: L. Michael Glode, Françoise Maxwell, Ian H. Maxwell

Publikováno v: Leukemia & Lymphoma. 7:457-462

Specifically targeted expression of a toxin gene potentially represents a novel approach to cancer therapy. With a view to the ablation of B-cell malignancies, we have constructed a plasmid, designated pTHA71, which expresses the A-chain of diphtheri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4f428ca384b197726e64b2e5cb59f3
https://doi.org/10.3109/10428199209049802

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