Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ian H. Kimball"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The voltage-gated sodium (NaV) channel subtype NaV1.7 plays a critical role in pain signaling, making it an important drug target. Here we studied the molecular interactions between μ-Conotoxin KIIIA (KIIIA) and the human NaV1.7 channel (hNaV1.7). W
Externí odkaz:
https://doaj.org/article/06d58ebefa964da4b71c735ad3867fad
Publikováno v:
Frontiers in Pharmacology. 14
The voltage-gated sodium (Nav) channel subtype Nav1.7 plays a critical role in pain signaling, making it an important drug target. A number of peptide toxins from cone snails (conotoxins) bind to the extracellular vestibule of the Nav channel pore an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc84b4ec1983d1bfd588b98accb7440
https://doi.org/10.3389/fphar.2023.1156855
https://doi.org/10.3389/fphar.2023.1156855
Autor:
Thasin Peyear, Olaf S. Andersen, Chris Dockendorff, Kenneth S. Eum, Radda Rusinova, Jon T. Sack, Ruchi Kapoor, Matthew W. Dodge, Stephen F. Martin, Richard W. Aldrich, Helgi I. Ingólfsson, Disha M. Gandhi, Ian H. Kimball
Publikováno v:
Biochemistry, vol 57, iss 18
Drugs do not act solely by canonical ligand-receptor binding interactions. Amphiphilic drugs partition into membranes, thereby perturbing bulk lipid bilayer properties and possibly altering the function of membrane proteins. Distinguishing membrane p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284ea8bb318664661bdde405b56e1306
https://doi.org/10.26434/chemrxiv.5908276.v1
https://doi.org/10.26434/chemrxiv.5908276.v1
Publikováno v:
Biophysical Journal. 110(3)
Voltage-gated sodium (Nav) channels drive the rapid depolarization of excitable tissues throughout the body, making them important drug targets for the treatment of many diseases, including chronic pain. Because the Nav1.7 subtype has been shown to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a0f9a1f20516e601118aa7c9cd7f5f
Autor:
Chris Dockendorff, Kenneth S. Eum, Stephen F. Martin, Radda Rusinova, Jon T. Sack, Ian H. Kimball, Helgi I. Ingólfsson, Richard W. Aldrich, Ruchi Kapoor, Thasin Peyear, Disha M. Gandhi, Olaf S. Andersen
Publikováno v:
Biophysical Journal. 112:246a-247a
The marine snail toxin BrMT, a 6-bromo-2-mercaptotryptamine dimer, is a powerful, hydrophobic modulator of Kv1 and Kv4 voltage-gated potassium channels. It remains unclear how BrMT modulates these diverse channels, and given BrMT's hydrophobicity, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cbe9309bcb541b25520cb286511e6c4
https://doi.org/10.1016/j.bpj.2016.11.1348
https://doi.org/10.1016/j.bpj.2016.11.1348
Publikováno v:
Biophysical Journal. 114:635a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bdc8bfefb1fa7cd26ab80ef0654c751
https://doi.org/10.1016/j.bpj.2017.11.3431
https://doi.org/10.1016/j.bpj.2017.11.3431
Autor:
Vladimir Yarov-Yarovoy, Brandon Pressly, Jenny Yam, Phuong T. Nguyen, Royce York, Jon T. Sack, Ian H. Kimball
Publikováno v:
Biophysical Journal. 112:240a
Voltage-gated sodium (Nav) channels play a key role in action potential generation in excitable cells and are targets of invertebrate toxins and therapeutics. The tarantula toxin SGTx-1 has been shown to target the domain IV voltage sensor (VSDIV) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b9a9c439b7d68ee65df5fc6baae312e
https://doi.org/10.1016/j.bpj.2016.11.1316
https://doi.org/10.1016/j.bpj.2016.11.1316
Autor:
Kenneth S. Eum, Bruce E. Cohen, Phuong T. Nguyen, Jon T. Sack, Vladimir Yarov-Yarovoy, Ian H. Kimball
Publikováno v:
Biophysical Journal. 108:574a
Voltage gated sodium (Nav) channels are responsible for initiation and propagation of action potentials in nerve and muscle. Due to their physiological roles, Nav channels are prime targets of natural toxins from a variety of organisms such as spider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e244a96fe24ae03e58d6ab15acba53
https://doi.org/10.1016/j.bpj.2014.11.3139
https://doi.org/10.1016/j.bpj.2014.11.3139