Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Ian H. Batty"'
Autor:
Jessica Schwermann, Ian H. Batty, Keunwook Lee, J. Crowe, J. S. C. Arthur, Victoria A. McGuire, S. J. O'Keefe, Alexander Gray, Susana G. Santos, Matthias Gaestel, Mark Boothby, Anna Aubareda, Natalia Ronkina, Jonathan L.E. Dean, Nicolas R. Leslie, Claire E. Monk
The stimulation of Toll-like receptors (TLRs) on macrophages by pathogen-associated molecular patterns (PAMPs) results in the activation of intracellular signaling pathways that are required for initiating a host immune response. Both phosphatidylino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3784d8346f368de4396036b8dfc7b9b
https://doi.org/10.1128/mcb.01691-12
https://doi.org/10.1128/mcb.01691-12
Publikováno v:
Advances in Biological Regulation. 52:205-213
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc524fc1688deea3ccbbb9bfb571b90c
https://doi.org/10.1016/j.advenzreg.2011.09.010
https://doi.org/10.1016/j.advenzreg.2011.09.010
Publikováno v:
Oncogene. 27:5464-5476
The PTEN tumour suppressor is a lipid and protein phosphatase that inhibits phosphoinositide 3-kinase (PI3K)-dependent signalling by dephosphorylating phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)). Here, we discuss the concept of PTEN as an '
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ec0d641c22c6c8d856f7be9d308ade
https://doi.org/10.1038/onc.2008.243
https://doi.org/10.1038/onc.2008.243
Publikováno v:
Journal of Biological Chemistry. 283:1372-1380
Influenza A virus NS1 protein stimulates host-cell phosphoinositide 3-kinase (PI3K) signaling by binding to the p85beta regulatory subunit of PI3K. Here, in an attempt to establish a mechanism for this activation, we report further on the functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682e51580837fa12308be7653bcb31ca
https://doi.org/10.1074/jbc.m708862200
https://doi.org/10.1074/jbc.m708862200
Autor:
C. Peter Downes, Miles J. Dixon, Jeroen van der Kaay, Alexander Gray, Ian H. Batty, Joan F. Telfer
Publikováno v:
Biochemical Journal. 407:255-266
Activation of class Ia PI3K (phosphoinositide 3-kinase) produces PtdInsP3, a vital intracellular mediator whose degradation generates additional lipid signals. In the present study vanadate analogues that inhibit PTPs (protein tyrosine phosphatases)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8a2165abd55f5a44e19ee62399451e
https://doi.org/10.1042/bj20070558
https://doi.org/10.1042/bj20070558
Publikováno v:
Oncogene. 26:7132-7142
Many tumors have chronically elevated activity of PI 3-kinase-dependent signaling pathways, caused largely by oncogenic mutation of PI 3-kinase itself or loss of the opposing tumor suppressor lipid phosphatase, PTEN. Several PI 3-kinase-dependent fee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56261e83c3fffb7b142cdc573781974
https://doi.org/10.1038/sj.onc.1210520
https://doi.org/10.1038/sj.onc.1210520
Publikováno v:
Biochemical Society Transactions. 35:188-192
The lipid phosphatase, PTEN (phosphatase and tensin homologue deleted on chromosome 10), is the product of a major tumour suppressor gene that antagonizes PI3K (phosphoinositide 3-kinase) signalling by dephosphorylating the 3-position of the inositol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351e2f29ca4d80488155a7aecc945b37
https://doi.org/10.1042/bst0350188
https://doi.org/10.1042/bst0350188
Publikováno v:
Biochemical Journal. 379:641-651
In 1321N1 astrocytoma cells, stimulation of the IGF-1 (insulin-like growth factor-1) receptor increased the association of PI3K [phosphoinositide (PI) 3-kinase] activity with IRS-1 (insulin re-ceptor substrate 1), and increased the cellular concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179434c04ab3270518e64cec872c4511
https://doi.org/10.1042/bj20031700
https://doi.org/10.1042/bj20031700
Publikováno v:
Biochemical Journal. 379:301-307
The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour-suppressor protein is a phosphoinositide 3-phosphatase which antagonizes phosphoinositide 3-kinase-dependent signalling by dephosphorylating PtdIns(3,4,5)P3. Most tumour-deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b884f4347c048e59a68b0732bb222ef
https://doi.org/10.1042/bj20031839
https://doi.org/10.1042/bj20031839
Autor:
Anudharan Balendran, Gary J. Litherland, Anne S. Blair, Ian H. Batty, C P Downes, Harinder S. Hundal, Eric Hajduch
Publikováno v:
Diabetologia. 44:173-183
Aims/hypothesis. Increased cellular production of ceramide has been implicated in the pathogenesis of insulin resistance and in the impaired utilisation of glucose. In this study we have used L6 muscle cells to investigate the mechanism by which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b730c3357c754dca1d2e2fc54b69bc
https://doi.org/10.1007/s001250051596
https://doi.org/10.1007/s001250051596