Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Ian H Guldner"'
Autor:
Bhavana Palakurthi, Shaneann R. Fross, Ian H. Guldner, Emilija Aleksandrovic, Xiyu Liu, Anna K. Martino, Qingfei Wang, Ryan A. Neff, Samantha M. Golomb, Cheryl Lewis, Yan Peng, Erin N. Howe, Siyuan Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Chemotherapy prior to immune checkpoint blockade (ICB) treatment appears to improve ICB efficacy but resistance to ICB remains a clinical challenge and is attributed to highly plastic myeloid cells associating with the tumor immune microenvi
Externí odkaz:
https://doaj.org/article/c56b41a143f64bd2b1690c2b26be55c4
Autor:
Erin N. Howe, Miranda D. Burnette, Melanie E. Justice, Patricia M. Schnepp, Victoria Hedrick, James W. Clancy, Ian H. Guldner, Alicia T. Lamere, Jun Li, Uma K. Aryal, Crislyn D’Souza-Schorey, Jeremiah J. Zartman, Siyuan Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Mechanisms governing adaptation of breast cancer to the brain metastatic microenvironment are unclear. Here, the authors use RNA-sequencing and Drosophila screening to identify Rab11b-mediated endosomal recycling as a unique mechanism for adaptation
Externí odkaz:
https://doaj.org/article/0b460feafbd444f4b8cc9b1a57749999
Autor:
Qingfei Wang, Ian H. Guldner, Samantha M. Golomb, Longhua Sun, Jack A. Harris, Xin Lu, Siyuan Zhang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The benefit of combined CDK4/6 and anti-HER2 therapy in breast cancer is limited due to acquired resistance. Here, the authors perform single-cell analysis and show an immature myeloid cell population to infiltrate resistant tumors, and that combined
Externí odkaz:
https://doaj.org/article/c38f32d16a5646e1b6161ac0f8f636b7
Autor:
Yingjia Ni, Keon R. Schmidt, Barnes A. Werner, Jenna K. Koenig, Ian H. Guldner, Patricia M. Schnepp, Xuejuan Tan, Lan Jiang, Misha Host, Longhua Sun, Erin N. Howe, Junmin Wu, Laurie E. Littlepage, Harikrishna Nakshatri, Siyuan Zhang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The use of of CDK4/6 inhibitors to treat patients with TNBC is limited by loss of Rb. Here, the authors show that a combination of CDK4/6 inhibitor and EGFR inhibitor is effective against DEDD-overexpressing TNBC, independent of Rb status.
Externí odkaz:
https://doaj.org/article/6cd4e5da2a3943ceb86081cf1bcee7ae
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100537- (2021)
Summary: High dimensional compositional and transcriptional profiling of heterogeneous brain-infiltrating leukocytes can lead to novel biological and therapeutic discoveries. High-quality single-cell leukocyte preparations are a prerequisite for opti
Externí odkaz:
https://doaj.org/article/52efb14e334549ea8bdf8a98bd490461
Autor:
Samantha M. Golomb, Ian H. Guldner, Anqi Zhao, Qingfei Wang, Bhavana Palakurthi, Emilija A. Aleksandrovic, Jacqueline A. Lopez, Shaun W. Lee, Kai Yang, Siyuan Zhang
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108438- (2020)
Summary: Phenotypic and functional plasticity of brain immune cells contribute to brain tissue homeostasis and disease. Immune cell plasticity is profoundly influenced by tissue microenvironment cues and systemic factors. Aging and gut microbiota dys
Externí odkaz:
https://doaj.org/article/625c5863cd5043339765b3fa37ba8693
Autor:
Ian H. Guldner, Tony Wyss-Coray
Publikováno v:
Nature. 615:588-589
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5ff76c3700461827640b899d4a04e0b
https://doi.org/10.1038/d41586-023-00600-5
https://doi.org/10.1038/d41586-023-00600-5
Autor:
Oliver Hahn, Aulden G Foltz, Micaiah Atkins, Blen Kedir, Patricia Moran-Losada, Ian H Guldner, Christy Munson, Fabian Kern, Róbert Pálovics, Nannan Lu, Hui Zhang, Achint Kaur, Jacob Hull, John R Huguenard, Sebastian Grönke, Benoit Lehallier, Linda Partridge, Andreas Keller, Tony Wyss-Coray
SummaryAging is the key risk factor for cognitive decline, yet the molecular changes underlying brain aging remain poorly understood. Here, we conducted spatiotemporal RNA-seq of the mouse brain, profiling 1,076 samples from 15 regions across 7 ages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99eb90106bb163f09ffeea4ec5402fff
https://doi.org/10.1101/2022.09.18.508419
https://doi.org/10.1101/2022.09.18.508419
Autor:
James W. Clancy, Erin N. Howe, Siyuan Zhang, Jeremiah J. Zartman, Victoria Hendrick, Melanie E. Justice, Ian H. Guldner, Jun Li, Alicia T. Lamere, Patricia M. Schnepp, Uma K. Aryal, Crislyn D'Souza-Schorey, Miranda Burnette
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Breast cancer brain metastases (BCBM) have a 5-20 year latency and account for 30% of mortality; however, mechanisms governing adaptation to the brain microenvironment remain poorly defined. We combine time-course RNA-sequencing of BCBM development w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f8270d4db5172b0c0e827c71408430
https://doaj.org/article/0b460feafbd444f4b8cc9b1a57749999
https://doaj.org/article/0b460feafbd444f4b8cc9b1a57749999
Autor:
William Kaliney, Toni M Page-Mayberry, M. Sharon Stack, Ian H. Guldner, Marwa Asem, Carlysa Oyama, Elizabeth I. Harper, Yueying Liu, Allison Young, Siyuan Zhang, Tyvette S. Hilliard, Jing Yang, Alejandro G Claure De La Zerda, Jeffery Johnson
Publikováno v:
Cancer Res
The noncanonical Wnt ligand Wnt5a is found in high concentrations in ascites of women with ovarian cancer. In this study, we elucidated the role of Wnt5a in ovarian cancer metastasis. Wnt5a promoted ovarian tumor cell adhesion to peritoneal mesotheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a871d4db9a66235572227b36c0533738
https://doi.org/10.1158/0008-5472.can-19-1601
https://doi.org/10.1158/0008-5472.can-19-1601