Zobrazeno 1 - 10
of 524
pro vyhledávání: '"Ian H, Frazer"'
Autor:
Jacoba I. Bromfield, Julian Zaugg, Rodney C. Straw, Julia Cathie, Annika Krueger, Debottam Sinha, Janin Chandra, Philip Hugenholtz, Ian H. Frazer
Publikováno v:
mSphere, Vol 9, Iss 4 (2024)
ABSTRACTHuman cutaneous squamous cell carcinomas (SCCs) and actinic keratoses (AK) display microbial dysbiosis with an enrichment of staphylococcal species, which have been implicated in AK and SCC progression. SCCs are common in both felines and can
Externí odkaz:
https://doaj.org/article/88ccea17fe92471c8c7559ba9a726bf6
Autor:
Andrew Causer, Xiao Tan, Xuehan Lu, Philip Moseley, Siok M. Teoh, Natalie Molotkov, Margaret McGrath, Taehyun Kim, Peter T. Simpson, Christopher Perry, Ian H. Frazer, Benedict Panizza, Rahul Ladwa, Quan Nguyen, Jazmina L. Gonzalez-Cruz
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-13 (2023)
Abstract Immune checkpoint inhibitor (ICI) therapy has had limited success (
Externí odkaz:
https://doaj.org/article/79b178e6e32c430f87e0d111d2dd01aa
Autor:
Ian H Frazer, Debottam Sinha, James W Wells, Quentin G Wright, Jazmina L Gonzalez Cruz, Graham Robert Leggatt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)
Background Skin cancers, particularly keratinocyte cancers, are the most commonly diagnosed tumors. Although surgery is often effective in early-stage disease, skin tumors are not always easily accessible, can reoccur and have the ability to metastas
Externí odkaz:
https://doaj.org/article/8f8282c0586e4ff888f281acec6f8aed
Autor:
H Peter Soyer, Ian H Frazer, Andrew Harvey, Margaret Veitch, Kimberly Beaumont, Rebecca Pouwer, Hui Yi Chew, Scott Campbell, Brian W Dymock, Terrie-Anne Cock, James W Wells
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background Immunosuppressive drugs such as tacrolimus have revolutionized our ability to transplant organs between individuals. Tacrolimus acts systemically to suppress the activity of T-cells within and around transplanted organs. However, tacrolimu
Externí odkaz:
https://doaj.org/article/79389749edd145c185881ce7f7b6a0b1
Autor:
Sachin Muralidharan, Sarah Ali, Lilin Yang, Joshua Badshah, Syeda Farah Zahir, Rubbiya A. Ali, Janin Chandra, Ian H. Frazer, Ranjeny Thomas, Ahmed M. Mehdi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The purpose of this study is to manually and semi-automatically curate a database and develop an R package that will act as a comprehensive resource to understand how biological processes are dysregulated due to interactions with environment
Externí odkaz:
https://doaj.org/article/52a0e459a18d46ae9f5a69950f8efc7f
Autor:
Annika Krueger, Julian Zaugg, Sarah Chisholm, Richard Linedale, Nancy Lachner, Siok Min Teoh, Zewen K. Tuong, Samuel W. Lukowski, Mark Morrison, H. Peter Soyer, Philip Hugenholtz, Michelle M. Hill, Ian H. Frazer
Publikováno v:
Frontiers in Microbiology, Vol 12 (2022)
Squamous cell carcinoma (SCC) is a common type of skin cancer that typically arises from premalignant precursor lesions named actinic keratoses (AK). Chronic inflammation is a well-known promoter of skin cancer progression. AK and SCC have been assoc
Externí odkaz:
https://doaj.org/article/a99987d820cf428b85ddd6179a0a0996
Autor:
Inga Rødahl, James Gotley, Stacey B. Andersen, Meihua Yu, Ahmed M. Mehdi, Angelika N. Christ, Emma E. Hamilton-Williams, Ian H. Frazer, Samuel W. Lukowski, Janin Chandra
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100842- (2021)
Summary: Here, we outline detailed protocols to isolate and profile murine splenic dendritic cells (DCs) through advanced flow cytometry of the myeloid compartment and single-cell transcriptomic profiling with integrated cell surface protein expressi
Externí odkaz:
https://doaj.org/article/bc293b82d9af4ba9b44accdf4fcffa02
Autor:
Zewen K. Tuong, Samuel W. Lukowski, Quan H. Nguyen, Janin Chandra, Chenhao Zhou, Kevin Gillinder, Abate A. Bashaw, John R. Ferdinand, Benjamin J. Stewart, Siok Min Teoh, Sarah J. Hanson, Katharina Devitt, Menna R. Clatworthy, Joseph E. Powell, Ian H. Frazer
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103326- (2021)
Summary: Langerhans cells (LC) are skin-resident antigen-presenting cells that regulate immune responses to epithelial microorganisms. Human papillomavirus (HPV) infection can promote malignant epithelial transformation. As LCs are considered importa
Externí odkaz:
https://doaj.org/article/08f0ec2087624af0b1807e9af63d460a
Autor:
Samuel W. Lukowski, Inga Rødahl, Samuel Kelly, Meihua Yu, James Gotley, Chenhao Zhou, Susan Millard, Stacey B. Andersen, Angelika N. Christ, Gabrielle Belz, Ian H. Frazer, Janin Chandra
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102402- (2021)
Summary: Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-ass
Externí odkaz:
https://doaj.org/article/d40a660dfb404f28a5f14a6069e10f15
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/430201622d694bf9b8ad8c3fb3f658bf