Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ian Gering"'
Autor:
Raphael Josef Eberle, Mônika Aparecida Coronado, Ian Gering, Simon Sommerhage, Karolina Korostov, Anja Stefanski, Kai Stühler, Victoria Kraemer-Schulien, Lara Blömeke, Oliver Bannach, Dieter Willbold
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0288138 (2023)
The primary function of virus proteases is the proteolytic processing of the viral polyprotein. These enzymes can also cleave host cell proteins, which is important for viral pathogenicity, modulation of cellular processes, viral replication, the def
Externí odkaz:
https://doaj.org/article/85e1f6af130448ba958b8c077df401f9
Autor:
Mônika A. Coronado, Ian Gering, Marc Sevenich, Danilo S. Olivier, Mohammadamin Mastalipour, Marcos S. Amaral, Dieter Willbold, Raphael J. Eberle
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 803 (2023)
Arboviruses such as Dengue, yellow fever, West Nile, and Zika are flaviviruses vector-borne RNA viruses transmitted biologically among vertebrate hosts by blood-taking vectors. Many flaviviruses are associated with neurological, viscerotropic, and he
Externí odkaz:
https://doaj.org/article/2e5fb815cba3460d9b0c0503779d2eb9
Autor:
Raphael J. Eberle, Ian Gering, Markus Tusche, Philipp N. Ostermann, Lisa Müller, Ortwin Adams, Heiner Schaal, Danilo S. Olivier, Marcos S. Amaral, Raghuvir K. Arni, Dieter Willbold, Mônika A. Coronado
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 540 (2022)
The C30 endopeptidase (3C-like protease; 3CLpro) is essential for the life cycle of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) since it plays a pivotal role in viral replication and transcription and, hence, is a promising drug targ
Externí odkaz:
https://doaj.org/article/86df6e13919542f8871f462489b7f278
Autor:
Anne K. Braczynski, Marc Sevenich, Ian Gering, Tatsiana Kupreichyk, Emil D. Agerschou, Yannick Kronimus, Pardes Habib, Matthias Stoldt, Dieter Willbold, Jörg B. Schulz, Jan-Philipp Bach, Björn H. Falkenburger, Wolfgang Hoyer
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 469 (2022)
Parkinson’s disease (PD) is associated with motor and non-motor symptoms and characterized by aggregates of alpha-synuclein (αSyn). Naturally occurring antibodies (nAbs) are part of the innate immune system, produced without prior contact to their
Externí odkaz:
https://doaj.org/article/c8cede19861348caa055202bb9372ad7
Autor:
Raphael J. Eberle, Danilo S. Olivier, Marcos S. Amaral, Ian Gering, Dieter Willbold, Raghuvir K. Arni, Monika A. Coronado
Publikováno v:
Viruses, Vol 13, Iss 5, p 873 (2021)
Since the first report of a new pneumonia disease in December 2019 (Wuhan, China) the WHO reported more than 148 million confirmed cases and 3.1 million losses globally up to now. The causative agent of COVID-19 (SARS-CoV-2) has spread worldwide, res
Externí odkaz:
https://doaj.org/article/d7306cc808ef4c2a9d048b59fdd52336
Autor:
Raphael J. Eberle, Marc Sevenich, Ian Gering, Lara Scharbert, Birgit Strodel, Nils A. Lakomek, Karoline Santur, Jeannine Mohrlüder, Mônika A. Coronado, Dieter Willbold
Publikováno v:
ACS Chemical Biology. 18:315-330
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dc1010a0c2e2a79776c46faedaab21c
https://doi.org/10.1021/acschembio.2c00735
https://doi.org/10.1021/acschembio.2c00735
Autor:
Tim Altendorf, Ian Gering, Beatrix Santiago-Schübel, Selma Aghabashlou Saisan, Gültekin Tamgüney, Markus Tusche, Dominik Honold, Sarah Schemmert, Wolfgang Hoyer, Jeannine Mohrlüder, Dieter Willbold
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2161
International journal of molecular sciences 24(3), 2161-(2023). doi:10.3390/ijms24032161
Volume 24
Issue 3
Pages: 2161
International journal of molecular sciences 24(3), 2161-(2023). doi:10.3390/ijms24032161
Alzheimer’s disease and other tauopathies are the world’s leading causes of dementia and memory loss. These diseases are thought to be caused by the misfolding and aggregation of the intracellular tau protein, ultimately leading to neurodegenerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15946d41b790fbc9860f17abcbb8cbe4
Autor:
Antje Willuweit, Swen Humpert, Michael Schöneck, Heike Endepols, Nicole Burda, Lothar Gremer, Ian Gering, Janine Kutzsche, N.Jon Shah, Karl-Josef Langen, Bernd Neumaier, Dieter Willbold, Alexander Drzezga
Publikováno v:
European journal of pharmaceutical sciences 184, 106421 (2023). doi:10.1016/j.ejps.2023.106421
Positron emission tomography (PET) imaging with radiotracers that bind to fibrillary amyloid β (Aβ) deposits is an important tool for the diagnosis of Alzheimer's disease (AD) and for the recruitment of patients into clinical trials. However, it ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22a8b3ca79cb0bfc92b7635c356b051
https://juser.fz-juelich.de/record/1005300
https://juser.fz-juelich.de/record/1005300
Autor:
Raphael Eberle, Marc Sevenich, Ian Gering, Lara Scharbert, Birgit Strodel, Karoline Santur, Jeannine Mohrlüder, Mônika Coronado, Dieter Willbold
During the replication process of SARS-CoV-2 the main protease of the virus (3-chymotrypsin-like protease (3CLpro)) plays a pivotal role and is essential for the life cycle of the pathogen. Numerous studies have been conducted so far, which have conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36935ab29cb02bf08b3877985bfc9610
https://doi.org/10.26434/chemrxiv-2022-rjdzz
https://doi.org/10.26434/chemrxiv-2022-rjdzz
Publikováno v:
Journal of virology 96(13), e00685-22 (2022). doi:10.1128/jvi.00685-22
Since its outbreak in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread with high transmission efficiency across the world, putting health care as well as economic systems under pressure. During the course of the pandemic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8620ee6d268533cf61a0ee8358099187
https://pubmed.ncbi.nlm.nih.gov/35674432
https://pubmed.ncbi.nlm.nih.gov/35674432