Complete response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT mutations and high tumour mutational burden

Autor: Joanne D. Stockton, Louise Tee, Celina Whalley, Jonathan James, Mark Dilworth, Rachel Wheat, Thomas Nieto, S-CORT Consortium, Ian Geh, João D. Barros-Silva, Andrew D. Beggs

Publikováno v: Radiation Oncology, Vol 16, Iss 1, Pp 1-12 (2021)

Abstract Background Pathological complete response (pathCR) in rectal cancer is beneficial, as up to 75% of patients do not experience regrowth of the primary tumour, but it is poorly understood. We hypothesised that the changes seen in the pre-treat

Externí odkaz: https://doaj.org/article/e778f28ee9ec4faebfafc381306dd3be

Ocular neuroendocrine tumour metastases - presentation & outcome

Autor: Husnain Shah, Mohamad Roji, Ozgul Ekmekcioglu, John Ayuk, Stacey Smith, Zaira Khan, Suzanne Vickrage, Joanne Kemp-Blake, Sian Humphries, Simon Hughes, Salvador Diaz-Cano, Mona Elshafie, Salil Karkhanis, Shishir Shetty, Ian Geh, Tahir Shah

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::634590ee2cc2aba59e39a6d6e3996065
https://doi.org/10.1530/endoabs.87.p9

Patterns and Predictors of Relapse Following Radical Chemoradiation Therapy Delivered Using Intensity Modulated Radiation Therapy With a Simultaneous Integrated Boost in Anal Squamous Cell Carcinoma

Autor: David Sebag-Montefiore, Amy Downing, Duncan C. Gilbert, Ian Geh, C. Jacobs, Cressida Lorimer, Wanangwa Clara Namelo, Paul Shaw, Richard Adams, Rebecca Shakir, Chris A. Jones, Rebecca Muirhead, Rachel Cooper

Publikováno v: International Journal of Radiation Oncology, Biology, Physics

Purpose Our purpose was to describe the patterns and predictors of treatment failure in patients receiving definitive chemoradiation therapy (CRT) for anal squamous cell carcinoma (ASCC), delivered using intensity modulated radiation therapy (IMRT).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be72285bc6f4fad8ed1bb2e101ab4343
https://doi.org/10.1016/j.ijrobp.2019.10.016

Author response for 'The Effects of Somatostatin Analogues on Glycaemia in the Treatment of Neuroendocrine Tumours'

Autor: Ananda Nahar, Raghavendar Palani, Hema Venkataraman, Shishir Shetty, Suzanne Vickrage, Kishen R Patel, Yasir S Elhassan, John Ayuk, Stacey Smith, Tahir Shah, Ian Geh, Joanne Kemp-Blake

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e388d09839b56fe459a1af9187910c5
https://doi.org/10.1111/jne.13064/v3/response1

Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study

Autor: Simon P Bach, Alexandra Gilbert, Kristian Brock, Stephan Korsgen, Ian Geh, James Hill, Talvinder Gill, Paul Hainsworth, Matthew G Tutton, Jim Khan, Jonathan Robinson, Mark Steward, Christopher Cunningham, Bruce Levy, Alan Beveridge, Kelly Handley, Manjinder Kaur, Natalie Marchevsky, Laura Magill, Ann Russell, Philip Quirke, Nicholas P West, David Sebag-Montefiore, Gina Brown, Peter Antonio, Alex Vince, Nick Hilken, Chakanaka Sidile, Adrian Wilcockson, Richard Peto, Tom Crosby, Brendan Moran, Julie Olliff, Katti Ashok, Simone Slawik, Andrew Smethurst, Rajaram Sripadam, Veena Tagore, Monica Terlizzo, Bearn Philip, Robert Davies, Susan Dodd, Sharadah Essapen, Pasha Nisar, Alexandra Stewart, Jonathan Trickett, Bansal Ashish, Peter Billings, Palanichamy Chandran, Conor Corr, Edward Favill, Simon Gollins, Peter Marsh, Andrew Maw, Rakha Neupane, Ramesh Rajagopal, Rachel Cooper, John Griffith, Paul Hatfield, Andy Lowe, Julian Ostrowski, Rhian Simpson, Richard Adams, Robert Bleehen, Michael Davies, Meleri Morgan, Darren Boone, Nicola Lacey, Ian Seddon, Bruce Sizer, Helen Stunell, Shaobin Wu, Maher Hadaki, Dominic Blunt, Susan Cleator, Ara Darzi, Robert Goldin, Paul Ziprin, Mike Dobson, Mark Pitt, Shabbir Susnerwala, Deborah Williamson, Georgina Howarth, Stephen Lee, Paul Wright, Tim Hoare, Alan Horgan, Fiona McDonald, Stephanie Needham, John Scott, Timothy Simmons, Debashis Biswas, James Hernon, Gaurav Kapur, Sandeep Kapur, James Sington, Christopher Speakman, William Stebbings, Stuart Williams, Madhavi Adusumalli, Anil Agarwal, David Borowski, Dharmendra Garg, Mohammed Hegab, Catherine Hobday, Veena Rao, Jyotsna Shrimankar, Mohamed Tabaqchali, David Wilson, Oliver Jones, Neil Mortensen, Andrew Slater, Aron Szuts, Lai Wang, Bryan Warren, Andrew Weaver, Mukhtar Ahmad, Julian Alexander, Maxine Flubacher, David Tarver, Suhail Baluch, Richard Beable, David Cowlishaw, Antony Higginson, Prokopios Vogiatzis, Neil Cruickshank, Howard Joy, David Peake, Ulises Zanetto, Mark Saunders, Arthur Sun-Myint, Mark Teo, Arthur Allan, John Glaholm, Mark Goldstein, Rahul Hejmadi, Gerald Langman, Dion Morton, Cyril Nelson, Deborah Tattersall, Stephen Falk, Robert Longman, Huw Roach, Jamshed Shabbir, Golda Shelley-Fraser, Michael Thomas, Neil Cripps, Yasser Haba, Guy Harris, Max Hookway, Jay Simson, Angela Skull, Tijani Umar

Publikováno v: The Lancet. Gastroenterology & Hepatology

Summary Background Radical surgery via total mesorectal excision might not be the optimal first-line treatment for early-stage rectal cancer. An organ-preserving strategy with selective total mesorectal excision could reduce the adverse effects of tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0429cb08c4dbffa6cf68653420de5021
https://eprints.whiterose.ac.uk/170564/1/PIIS2468125320303332.pdf