Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Ian G Tucker"'
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215612 (2019)
Understanding the effects of cognitive enhancing drugs is an important area of research. Much of the research, however, has focused on restoring memory following some sort of disruption to the brain, such as damage or injections of scopolamine. Anira
Externí odkaz:
https://doaj.org/article/b8cd0cb98bcc440692ec1a7300135e8b
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163795 (2016)
Gastrointestinal absorption and disposition of ketones is complex. Recent work describing the pharmacokinetics (PK) of d-β-hydroxybutyrate (BHB) following oral ingestion of a ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate) found multiple
Externí odkaz:
https://doaj.org/article/1cfb76a451ed49168b66e13c1be5cbb5
Publikováno v:
JDS Communications.
Publikováno v:
Pharmaceutical Research.
Publikováno v:
Journal of Pharmacy and Pharmacology. 72:507-518
Objectives Ketotifen (K) and its active metabolite norketotifen (N) exist as optically active atropisomers. They both have antihistaminic and anti-inflammatory properties but the S-atropisomer of N (SN) causes less sedation than K and RN in rodents.
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
In vitro dissolution testing is a useful quality control tool to discriminate the formulations and to approximate the in vivo drug release profiles. A dissolution apparatus has been custom-made for dissolution testing of dry powder formulations in a
Publikováno v:
Colloids and surfaces. B, Biointerfaces. 217
The interaction of nanoparticles with Caco-2 monolayers in cell culture underpins our predictions of the uptake of nanoformulations in vivo for drug delivery. Cell-penetrating peptides (CPP), such as oligoarginine, are currently of interest to enhanc
Publikováno v:
International Journal of Pharmaceutics. 559:235-244
A dissolution apparatus that uses a small volume of stationary medium (25 μL) has been developed for in vitro dissolution testing of respirable drug particles and used to evaluate the dissolution of two anti-tubercular drugs, moxifloxacin and ethion
Autor:
Rajesh Katare, Shyamal C. Das, Prakash Khadka, Jack Dummer, Philip C. Hill, Shubhra Sinha, Ian G. Tucker
Publikováno v:
International journal of pharmaceutics. 597
Inhaled delivery of rifampicin has the potential to achieve high drug concentrations in the lung and the blood for efficient treatment of tuberculosis (TB). Due to its existence as polymorphs, in vivo evaluation of the respiratory tract safety of inh
Autor:
Philip C. Hill, Prakash Khadka, Shyamal C. Das, Jack Dummer, Rajesh Katare, Shubhra Sinha, Ian G. Tucker
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 162
Rifampicin is one of the key drugs used to treat tuberculosis and is currently used orally. The use of higher oral doses of rifampicin is desired for better therapeutic efficacy, but this is accompanied by increased risk of systemic toxicity thus lim