Výsledky vyhledávání - "Ian G Mcfarlane"

Akademický článek

Autoimmune Hepatitis: Clinical Manifestations and Diagnostic Criteria

Autor: Ian G Mcfarlane

Publikováno v: Canadian Journal of Gastroenterology, Vol 15, Iss 2, Pp 107-113 (2001)

In 1998, the International Autoimmune Hepatitis Group - a panel of 40 hepatologists and hepatopathologists from 17 countries who have a particular interest in autoimmune hepatitis (AIH) - undertook a review, in light of subsequent experience, of the

Externí odkaz: https://doaj.org/article/15cbbf606af94bf6aa21fcc1fd6c9437

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Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia

Autor: Matej Orešič, Michael Baker, Vidya Velagapudi, Sergio Rodriguez-Cuenca, Iman S. Gurung, Mark Campbell, Gema Medina-Gomez, Antonio Vidal-Puig, Adrienn Kis, Christopher L.-H. Huang, Sudeshna Guha Neogi, Christopher J. Lelliott, Ian G. McFarlane, Andrew A. Grace

Publikováno v: Gurung, I S, Medina-Gomez, G, Kis, A, Baker, M, Velagapudi, V, Guha Neogi, S, Campbell, M, Rodriguez-Cuenca, S, Lelliott, C, McFarlane, I, Orešič, M, Grace, A A, Vidal-Puig, A & Huang, C L-H 2011, ' Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia ', Cardiovascular Research, vol. 92, no. 1, pp. 29-38 . https://doi.org/10.1093/cvr/cvr155

AimsPeroxisome proliferator-activated receptor-γ coactivators PGC1α and PGC1β modulate mitochondrial biogenesis and energy homeostasis. The function of these transcriptional coactivators is impaired in obesity, insulin resistance, and type 2 diabe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a381f0086dbe3ff2faa855b6e5a9da9d
https://doi.org/10.1093/cvr/cvr155

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Simplified criteria for the diagnosis of autoimmune hepatitis

Autor: E. M. Hennes, Ian G. McFarlane, Harald Hofer, Peter R. Galle, Hans-Peter Dienes, George N. Dalekos, Gilda Porta, Francesco B. Bianchi, Kirsten Muri Boberg, Albert J. Czaja, Albert Parés, Christoph Schramm, Minoru Shibata, AW Lohse, Paulo Lisboa Bittencourt, Edward L. Krawitt, Mikio Zeniya, Barbara Eisenmann de Torres

Publikováno v: Hepatology. 48:169-176

Diagnosis of autoimmune hepatitis (AIH) may be challenging. However, early diagnosis is important because immunosuppression is life-saving. Diagnostic criteria of the International Autoimmune Hepatitis Group (IAIHG) were complex and purely meant for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fb8022be1a90017e19d83a35f66fe6
https://doi.org/10.1002/hep.22322

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Mechanisms of Liver Injury in Chronic Active Hepatitis

Autor: Ian G. McFarlane, Allan D. Thomson, Roger Williams, Adrian L. W. F. Eddleston, Malcolm A. G. Cochrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1e7fd7a666874a612d4b5cd18121707
https://doi.org/10.1159/000428285

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Autoimmune hepatitis (AIH) in the elderly: A systematic retrospective analysis of a large group of consecutive patients with definite AIH followed at a tertiary referral centre

Autor: Bernard Portmann, Michael A. Heneghan, Thawab Al-Chalabi, Ian G. McFarlane, Sylvia Boccato

Publikováno v: Journal of Hepatology. 45:575-583

A few reports have suggested that AIH may be less severe in the elderly and may be underdiagnosed, but there is a paucity of data.We have undertaken a systematic analysis of 164 consecutive patients (36 males, 128 females) with definite AIH (median s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb2feac5906e02f18c37bd3402cacae
https://doi.org/10.1016/j.jhep.2006.04.007

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Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease

Autor: Ian G. McFarlane, Wolfgang Vogel, Heinz Zoller, David Halsall, Sylvia Stadlmann, Igor Theurl, Elizabeta Nemeth, Tomas Ganz, David Oxley, Timothy M. Cox

Publikováno v: Hepatology. 42:466-472

Ferroportin disease (hemochromatosis type 4) is a recently recognized disorder of human iron metabolism, characterized by iron deposition in macrophages, including Kupffer cells. Mutations in the gene encoding ferroportin 1, a cellular iron exporter,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a1071faf42b6945785bb2ee8078770
https://doi.org/10.1002/hep.20775

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Clinical evaluation of chemokine and enzymatic biomarkers of Gaucher disease

Autor: Timothy M. Cox, J. Paul Schofield, Ian G. McFarlane, Patrick Deegan, Mary Teresa Moran, Rolf G. Boot, Johannes M. F. G. Aerts

Publikováno v: Blood cells, molecules & diseases, 35(2), 259-267. Academic Press Inc.

Purpose: Gaucher disease is an exemplary orphan disorder. Enzyme replacement therapy with imiglucerase is effective, but very expensive. To improve the assessment of severity of disease and responses to this costly treatment, we have evaluated severa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4105e7c5e9544a448c23f720074ea336
https://doi.org/10.1016/j.bcmd.2005.05.005

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