A neuronal MAP kinase constrains growth of a Caenorhabditis elegans sensory dendrite throughout the life of the organism.

Autor: Ian G McLachlan, Isabel Beets, Mario de Bono, Maxwell G Heiman

Publikováno v: PLoS Genetics, Vol 14, Iss 6, p e1007435 (2018)

Neurons develop elaborate morphologies that provide a model for understanding cellular architecture. By studying C. elegans sensory dendrites, we previously identified genes that act to promote the extension of ciliated sensory dendrites during embry

Externí odkaz: https://doaj.org/article/82de2ba15e5d4cada11084eed9a44973

Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression inC. elegans

Autor: Travis Kyani-Rogers, Alison Philbrook, Ian G. McLachlan, Steven W. Flavell, Michael P. O’Donnell, Piali Sengupta

Developmental experiences play critical roles in shaping adult physiology and behavior. We and others previously showed that adultC. eleganswhich transiently experienced dauer arrest during development (PD: post-dauer) exhibit distinct gene expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1ba616e21c476625944dd62b37b9875
https://doi.org/10.1101/2022.06.07.495158

Dendrites with specialized glial attachments develop by retrograde extension using SAX-7 and GRDN-1

Autor: Ian G. McLachlan, Elizabeth R. Cebul, Maxwell G. Heiman

Publikováno v: Development

Dendrites develop elaborate morphologies in concert with surrounding glia, but the molecules that coordinate dendrite and glial morphogenesis are mostly unknown.C. elegansoffers a powerful model for identifying such factors. Previous work in this sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343eaece162a15ae83150da7c20492dc
https://doi.org/10.1101/801761

Morphogenesis of neurons and glia within an epithelium

Autor: Claire R. Williams, Megan K. Chong, Isabel I. C. Low, Bradley M. Wierbowski, Irina Kolotuev, Maxwell G. Heiman, Ian G. McLachlan

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2019, 146 (4), pp.dev171124. ⟨10.1242/dev.171124⟩
Development, vol. 146, no. 4
Development (Cambridge, England), 2019, 146 (4), pp.dev171124. ⟨10.1242/dev.171124⟩

To sense the outside world, some neurons protrude across epithelia, the cellular barriers that line every surface of our bodies. To study the morphogenesis of such neurons, we examined theC. elegansamphid, in which dendrites protrude through a glial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d9f4b9843c254feff516091cf3a4db
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02127177

ASICs Mediate Food Responses in an Enteric Serotonergic Neuron that Controls Foraging Behaviors

Autor: Daniel A. Colón-Ramos, Ian G. McLachlan, Steven W. Flavell, Gurrein K. Madan, Stephanie K. Yu, Joshua R. Powers, Eden Abebe, Jeffrey L. Rhoades, Jessica C. Nelson, Ijeoma Nwabudike

Publikováno v: PMC

Animals must respond to the ingestion of food by generating adaptive behaviors, but the role of gut-brain signaling in behavioral regulation is poorly understood. Here, we identify conserved ion channels in an enteric serotonergic neuron that mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1dd4a4108a209a8c1b84d4503d3e8fc
https://doi.org/10.1016/j.cell.2018.11.023