Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Ian G Ganley"'
Autor:
Francois Singh, Alan R Prescott, Philippa Rosewell, Graeme Ball, Alastair D Reith, Ian G Ganley
Publikováno v:
eLife, Vol 10 (2021)
Parkinson’s disease (PD) is a major and progressive neurodegenerative disorder, yet the biological mechanisms involved in its aetiology are poorly understood. Evidence links this disorder with mitochondrial dysfunction and/or impaired lysosomal deg
Externí odkaz:
https://doaj.org/article/1fe20ff9e4834b2f99a5c0d252b7aa97
Autor:
Francois Singh, Lea Wilhelm, Alan R. Prescott, Kevin Ostacolo, Jin-Feng Zhao, Margret H. Ogmundsdottir, Ian G. Ganley
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
ABSTRACTPINK1, mutated in familial forms of Parkinson’s disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically in mice as loss of PINK1 does not alter basal mitophagy le
Externí odkaz:
https://doaj.org/article/5b57ed0a9adb48e88193d7ed8114fd86
Autor:
Aidan Anderson, Nada Alfahad, Dulani Wimalachandra, Kaouthar Bouzinab, Paula Rudzinska, Heather Wood, Isabel Fazey, Heping Xu, Timothy J. Lyons, Nicholas M. Barnes, Parth Narendran, Janet M. Lord, Saaeha Rauz, Ian G. Ganley, Tim M. Curtis, Graham R. Wallace, Jose R. Hombrebueno
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The recovery of mitochondrial quality control (MQC) may bring innovative solutions for neuroprotection, while imposing a significant challenge given the need of holistic approaches to restore mitochondrial dynamics (fusion/fission) and turno
Externí odkaz:
https://doaj.org/article/49bb462680fd472a9c0826d8dc86da53
Autor:
Andrew M Hau, Jeffrey A Greenwood, Christiane V Löhr, Jeffrey D Serrill, Philip J Proteau, Ian G Ganley, Kerry L McPhail, Jane E Ishmael
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65250 (2013)
Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cance
Externí odkaz:
https://doaj.org/article/ad6d170e6dbe49d98aa2c9990206bcf2
Publikováno v:
PLoS ONE, Vol 1, p e19 (2006)
Niemann-Pick Type C (NPC) disease is a neurodegenerative disease that is characterized by the accumulation of cholesterol and glycosphingolipids in the late endocytic pathway. The majority of NPC cases are due to mutations in the NPC1 gene. The preci
Externí odkaz:
https://doaj.org/article/a5e498289c5c4668811fd9128ae226a3
Autor:
Tracy-Shi Zhang Fang, Yu Sun, Andrew C. Pearce, Simona Eleuteri, Mark Kemp, Christopher A. Luckhurst, Rachel Williams, Ross Mills, Sarah Almond, Laura Burzynski, Nóra M. Márkus, Christopher J. Lelliott, Natasha A. Karp, David J. Adams, Stephen P. Jackson, Jin-Feng Zhao, Ian G. Ganley, Paul W. Thompson, Gabriel Balmus, David K. Simon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson’s disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic PD. This α-synucleinopathy leads to mitochondrial dysfunction, which may dr
Externí odkaz:
https://doaj.org/article/231adfbea4cd447195e9caff8d44823d
Autor:
Paloma B. Liton, Kathleen Boesze-Battaglia, Michael E. Boulton, Patricia Boya, Thomas A. Ferguson, Ian G. Ganley, Anu Kauppinnen, Gordon W. Laurie, Noboru Mizushima, Hideaki Morishita, Rossella Russo, Jaya Sadda, Rajalekshmy Shyam, Debasish Sinha, Debra A. Thompson, David N. Zacks
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Autophagy is a catabolic self-degradative pathway that promotes the degradation and recycling of intracellular material through the lysosomal compartment. Although first believed to function in conditions of nutritional stress, autophagy is emerging
Externí odkaz:
https://doaj.org/article/061946d58aef4da69c2648d6e73ee4f8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells, which can generate and sequester toxic reactive oxygen species (ROS) in response to oxidative stress. Oxidative stress-stimulated ROS production results in ATP dep
Externí odkaz:
https://doaj.org/article/015be75ad5d444fd95e8f8ecdccc05a6
Autor:
Xingui Liu, Alexia F. Kalogeropulou, Sofia Domingos, Nikolai Makukhin, Raja S. Nirujogi, Francois Singh, Natalia Shpiro, Anton Saalfrank, Esther Sammler, Ian G. Ganley, Rui Moreira, Dario R. Alessi, Alessio Ciulli
Publikováno v:
Journal of the American Chemical Society. 144:16930-16952
Leucine-rich repeat kinase 2 (LRRK2) is one of the most promising targets for Parkinson's disease. LRRK2-targeting strategies have primarily focused on type 1 kinase inhibitors, which, however, have limitations as the inhibited protein can interfere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a3eb51d09b3ba5e57b1a459b49ca89
https://doi.org/10.1021/jacs.2c05499
https://doi.org/10.1021/jacs.2c05499
Autor:
Pawan Kishor Singh, Ilaria Volpi, Shalini Agarwal, Léa P. Wilhelm, Giada Becchi, Thomas Macartney, Rachel Toth, Adrien Rousseau, Glenn R. Masson, Ian G. Ganley, Miratul M. K. Muqit
Loss of function mutations of the PINK1 kinase cause familial early-onset Parkinson’s disease. PINK1 is activated upon mitochondrial damage to phosphorylate Ubiquitin and Parkin to trigger removal of damaged mitochondria by autophagy (mitophagy). P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::015634019fa7f6fa102df5340138bb7b
https://doi.org/10.1101/2023.03.20.533516
https://doi.org/10.1101/2023.03.20.533516
