Cell-Penetrating Peptides: Are They Useful Excipients in Botulinum Toxin Formulations?

Autor: James Austerberry, Julia Morrison, Saif Shubber, Daniel Parreirinha, Hamzah Baig, Rubens Lima, Ian Fox, Katarzyna Wegner, Eoghan Molloy, Daniel Higazi

Publikováno v: Toxicon. 214:S5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53108a409fd43b7e635c4b5c9579ac41
https://doi.org/10.1016/j.toxicon.2021.11.020

Atmospheric scattering of energetic electrons from near-Earth space

Autor: Jessica Artinger, Jordan Miller, Maxwell Chung, Xiao-Jia Zhang, Ethan Tsai, Kathryn Hector, Austin Villegas, Patrick Cruce, Christopher Shaffer, Duncan Frederick, Stephen Sundin, Elisa Park, Michael Anderson, Anthony Gildemeister, Austin Norris, David Leneman, Reuben Rozario, Rommel Castro, Akhil Palla, Carter Pedersen, Suyash Kumar, Jeffrey Asher, Jason Mao, Andrei Runov, Erica Xie, Anais Zarifian, Robert J. Strangeway, R. Caron, Kevin Lian, Benjamin Domae, Micah Cliffe, Cass Wong, Wen Li, Wynne Turner, Alex Gilbert, Laura Iglesias, Michelle Nguyen, Kelly Nguyen, Emmons McKinney, Cian Costello, Matt Wasden, Nick Adair, Jiashu Wu, Ian Fox, Akshaya Subramanian, Anton Artemyev, Chanel Young, Drew Turner, Gary Zhang, James King, Sarah Eldin, Alexander Gonzalez, Matt Nuesca, Donna Branchevsky, Emmanuel Masongsong, Graham Wing, J. B. Blake, Gary Chao, Lydia Adair, Renee Krieger, Aysen Tan, Kyle Colton, Matthew Allen, Nathan Chung, M. J. Lawson, Rebecca Yap, Michael Capitelli, Eric Grimes, C. Wilkins, Richard E. Wirz, Alexa Roosnovo, Ryan Seaton, Brayden Hesford, Sharvani Jha, Lauren Fitgibbon, Cynthia Russell, Erik Rye, Michael Arreola-Zamora, Danny Depe, Jiang Liu, Vassilis Angelopoulos, Ziyuan Qu, Alex Flemming

In near-Earth space, the magnetosphere, energetic electrons (tens to thousands of kiloelectron volts) orbit around Earth, forming the radiation belts. When scattered by magnetospheric processes, these electrons precipitate to the upper atmosphere, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83a6cbf3cd044180b76a6a601e22868b
https://doi.org/10.21203/rs.3.rs-319558/v1

The ELFIN Mission

Autor: V. Angelopoulos, A. Flemming, M. R. Capitelli, C. L. Russell, J. King, Eric Grimes, R. Caron, M. J. Lawson, A. Palla, Susmit Jha, K. Hector, S. R. Sundin, A. Subramanian, Drew Turner, L. Bingley, A. Gilbert, M. Cliffe, Xiao-Jia Zhang, Yuri Shprits, R. Castro, E. Tsai, A. Zarifian, Ian Fox, Richard E. Wirz, Andrei Runov, C. E. Pedersen, A. Tan, C. Wilkins, A. Norris, B. Hesford, E. McKinney, C. Wong, E. Rye, Catherine E. Costello, N. Adair, D. Depe, R. Krieger, R. Rozario, C. Shaffer, Emmanuel Masongsong, J. Mao, J. B. Blake, N. Kang, M. Wasden, K. Colton, Robert J. Strangeway, D. Leneman, M. Allen, Wen Li, B. W. Domae, R. Yap, W. Greer, M. Chung, Anton Artemyev, A. J. Villegas, K. Lian, G. Chao, M. Arreola-Zamora, D. Hinkley, M. Nuesca, S. Yamamoto, J. P. Miller, A. Gildemeister, G. Wing, W. Turner, Jiang Liu, P. Cruce, V. A. Sergeev, A. Gonzalez, D. Branchevsky, N. Chung, J. Asher, M. Anderson, J. Artinger, R. Seaton, L. Fitzgibbon, G. Y. Zhang, Z. Qu, E. Xie, D. M. Frederick, S. Eldin, E. S. Y. Park

Publikováno v: Space science reviews, vol 216, iss 5
Space Science Reviews

The Electron Loss and Fields Investigation with a Spatio-Temporal Ambiguity-Resolving option (ELFIN-STAR, or simply: ELFIN) mission comprises two identical 3-Unit (3U) CubeSats on a polar (~93deg inclination), nearly circular, low-Earth (~450 km alti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e27f276bf186cae245962785a7b7a95
https://doi.org/10.1007/s11214-020-00721-7

Bu4N+-Controlled Addition and Olefination with Ethyl 2-(Trimethylsilyl)acetate via Silicon Activation

Autor: Dilwyn J. Roberts, Manas Das, Ian Fox, Atul Manvar, Donal F. O'Shea

Publikováno v: Synlett. 28:2401-2406

Catalytic Bu4NOAc as silicon activator of ethyl 2-(trimethylsilyl)acetate, in THF, was utilized for the synthesis of β-hydroxy esters, whereas employing catalytic Bu4NOTMS gave α,β-unsaturated esters. The established reaction conditions were appli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8899836ee91c167d36a523e771006acf
https://doi.org/10.1055/s-0036-1588805

Mutations in the glycosyltransferase domain of GLT8D1 are associated with familial amyotrophic lateral sclerosis

Autor: Matthieu Moisse, Jesus S. Mora, Ian Fox, Tennore Ramesh, Philip Van Damme, Mbombe Kazoka, Abdelilah Assialioui, Karen E. Morrison, Orla Hardiman, Matthew Wyles, Mónica Povedano Panades, Christopher Shaw, John Landers, Janine Kirby, Christopher J McDermott, A. Nazli Basak, Henry Robins, Johnathan Cooper-Knock, Adrian Higginbottom, Lydia M. Castelli, Theresa Walsh, Isabell Niedermoser, Alexander Beer, Tobias Moll, Paul R. Heath, Pamela J. Shaw, Ammar Al-Chalabi, Wim Robberecht, Guillaume M. Hautbergue

Publikováno v: Cell Reports
Cooper-Knock, J, Moll, T, Ramesh, T, Castelli, L, Beer, A, Robins, H, Fox, I, Niedermoser, I, Van Damme, P, Moisse, M, Robberecht, W, Hardiman, O, Panades, M P, Assialioui, A, Mora, J S, Basak, A N, Morrison, K E, Shaw, C E, Al-Chalabi, A, Landers, J E, Wyles, M, Heath, P R, Higginbottom, A, Walsh, T, Kazoka, M, McDermott, C J, Hautbergue, G M, Kirby, J & Shaw, P J 2019, ' Mutations in the glycosyltransferase domain of GLT8D1 are associated with familial amyotrophic lateral sclerosis ', Cell Reports, vol. 26, no. 9, pp. 2298-2306.e5 . https://doi.org/10.1016/j.celrep.2019.02.006

Summary Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder without effective neuroprotective therapy. Known genetic variants impair pathways, including RNA processing, axonal transport, and protein homeostasis. We report ALS-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861d5712fbc95278be1a2cd90804a15c
https://eprints.whiterose.ac.uk/142642/8/PIIS2211124719301688.pdf