Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Ian F. Hermans"'
Autor:
Anna H. Mooney, Sarah L. Draper, Olivia K. Burn, Regan J. Anderson, Benjamin J. Compton, Chingwen Tang, Kathryn J. Farrand, Pietro Di Lucia, Micol Ravà, Valeria Fumagalli, Leonardo Giustini, Elisa Bono, Dale I. Godfrey, William R. Heath, Weiming Yuan, Francis V. Chisari, Luca G. Guidotti, Matteo Iannacone, John Sidney, Alessandro Sette, Shivali A. Gulab, Gavin F. Painter, Ian F. Hermans
Publikováno v:
JHEP Reports, Vol 6, Iss 5, Pp 101038- (2024)
Background & Aims: Liver diseases resulting from chronic HBV infection are a significant cause of morbidity and mortality. Vaccines that elicit T-cell responses capable of controlling the virus represent a treatment strategy with potential for long-t
Externí odkaz:
https://doaj.org/article/ee2629abc47b4a819f89b5234ea4bfff
Autor:
Theresa E. Pankhurst, Kaitlin H. Buick, Joshua L. Lange, Andrew J. Marshall, Kaileen R. Button, Olga R. Palmer, Kathryn J. Farrand, Isabelle Montgomerie, Thomas W. Bird, Ngarangi C. Mason, Joanna Kuang, Benjamin J. Compton, Davide Comoletti, Mariolina Salio, Vincenzo Cerundolo, Miguel E. Quiñones-Mateu, Gavin F. Painter, Ian F. Hermans, Lisa M. Connor
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112310- (2023)
Summary: Protective immune responses against respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the mucosal immune system. However, most licensed vaccines are administered
Externí odkaz:
https://doaj.org/article/a3b5f150bb494cd2ab24b2e9cd902159
Autor:
Ellie-May Jarvis, Shaun Collings, Astrid Authier-Hall, Nathaniel Dasyam, Brendan Luey, John Nacey, Gavin F. Painter, Brett Delahunt, Ian F. Hermans, Robert Weinkove
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Prostate cancer is the second most common cancer in men worldwide. Despite an abundance of prostate-specific antigens, immunotherapies have yet to become a standard of care, potentially limited by T-cell dysfunction. Up to 10% of human circulating T-
Externí odkaz:
https://doaj.org/article/d726908ea6fa4815a7d301e76cd6be96
Autor:
Abigail V. Sharrock, Sarah P. McManaway, Michelle H. Rich, Jeff S. Mumm, Ian F. Hermans, Moana Tercel, Frederik B. Pruijn, David F. Ackerley
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Bacterial nitroreductase enzymes that can efficiently convert nitroaromatic prodrugs to a cytotoxic form have numerous applications in targeted cellular ablation. For example, the generation of cytotoxic metabolites that have low bystander potential
Externí odkaz:
https://doaj.org/article/84cc219bd1d44edcb71e6c37eef0a1bb
Autor:
Yanyan Li, Katherine Woods, Amber Parry-Strong, Regan J. Anderson, Celina Capistrano, Aurelie Gestin, Gavin F. Painter, Ian F. Hermans, Jeremy Krebs, Olivier Gasser
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The immune system plays a significant role in controlling systemic metabolism. Innate-like T (ILT) cells in particular, such as mucosal-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells and γδ T cell receptor expressing c
Externí odkaz:
https://doaj.org/article/f7bea488c2e14977bbb50c30193e257e
Publikováno v:
BMC Pulmonary Medicine, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background Asthma inflammatory phenotypes are often defined by relative cell counts of airway eosinophils/neutrophils. However, the importance of neutrophilia remains unclear, as does the effect of ICS treatment on asthma phenotypes and airw
Externí odkaz:
https://doaj.org/article/5e39a664ed0f40c59e6ec2db0a6fc618
Publikováno v:
Cells, Vol 10, Iss 5, p 1006 (2021)
The magnitude of the host immune response can be regulated by either stimulatory or inhibitory immune checkpoint molecules. Receptor-ligand binding between inhibitory molecules is often exploited by tumours to suppress anti-tumour immune responses. I
Externí odkaz:
https://doaj.org/article/005f909081724a54accec5e2af897a59
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Bloodstream infections induce considerable morbidity, high mortality, and represent a significant burden of cost in health care; however, our understanding of the immune response to bacteremia is incomplete. Langerin+ CD8α+ dendritic cells (DCs), re
Externí odkaz:
https://doaj.org/article/a38310d9c62a4cd6aabe9eb5dea351ad
Autor:
Cameron S. Field, Martin K. Hunn, Peter M. Ferguson, Christiane Ruedl, Lindsay R. Ancelet, Ian F. Hermans
Publikováno v:
OncoImmunology, Vol 7, Iss 1 (2018)
Vaccine-mediated cancer treatment is unlikely to induce long-term survival unless suppressive mechanisms are overcome. Given the success of antibody-mediated immune checkpoint blockade in relieving regulation of endogenous anti-tumor T cell responses
Externí odkaz:
https://doaj.org/article/b0405e0c2f634b57a478c582d65f933c
Publikováno v:
Haematologica, Vol 98, Iss 3 (2013)
Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell r
Externí odkaz:
https://doaj.org/article/e02049bc1f5d424f86630e0c0e59ef61