Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Ian F. Hermans"'
Autor:
Anna H. Mooney, Sarah L. Draper, Olivia K. Burn, Regan J. Anderson, Benjamin J. Compton, Chingwen Tang, Kathryn J. Farrand, Pietro Di Lucia, Micol Ravà, Valeria Fumagalli, Leonardo Giustini, Elisa Bono, Dale I. Godfrey, William R. Heath, Weiming Yuan, Francis V. Chisari, Luca G. Guidotti, Matteo Iannacone, John Sidney, Alessandro Sette, Shivali A. Gulab, Gavin F. Painter, Ian F. Hermans
Publikováno v:
JHEP Reports, Vol 6, Iss 5, Pp 101038- (2024)
Background & Aims: Liver diseases resulting from chronic HBV infection are a significant cause of morbidity and mortality. Vaccines that elicit T-cell responses capable of controlling the virus represent a treatment strategy with potential for long-t
Externí odkaz:
https://doaj.org/article/ee2629abc47b4a819f89b5234ea4bfff
Autor:
Ian F Hermans, Christoph H Tripp, Florian Hornsteiner, Zlatko Trajanoski, Patrizia Stoitzner, Marc Schmitz, Natascha Hermann-Kleiter, Francesca Finotello, Janine Vierthaler, Helen Strandt, Antonia Resag, Zhe Fu, Markus Ausserhofer, Sophie Dieckmann, Markus Kanduth, Kathryn Farrand, Sarah Bregar, Niloofar Nemati, Athanasios Seretis, Sudhir Morla, David Mullins, Guido Wollmann, Franca Ronchese
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Tumor-targeted therapy causes impressive tumor regression, but the emergence of resistance limits long-term survival benefits in patients. Little information is available on the role of the myeloid cell network, especially dendritic cells
Externí odkaz:
https://doaj.org/article/8ba13b7814a54dc4b691708cf8293e28
Autor:
Theresa E. Pankhurst, Kaitlin H. Buick, Joshua L. Lange, Andrew J. Marshall, Kaileen R. Button, Olga R. Palmer, Kathryn J. Farrand, Isabelle Montgomerie, Thomas W. Bird, Ngarangi C. Mason, Joanna Kuang, Benjamin J. Compton, Davide Comoletti, Mariolina Salio, Vincenzo Cerundolo, Miguel E. Quiñones-Mateu, Gavin F. Painter, Ian F. Hermans, Lisa M. Connor
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112310- (2023)
Summary: Protective immune responses against respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the mucosal immune system. However, most licensed vaccines are administered
Externí odkaz:
https://doaj.org/article/a3b5f150bb494cd2ab24b2e9cd902159
Autor:
Kef K Prasit, Laura Ferrer-Font, Olivia K Burn, Regan J Anderson, Benjamin J Compton, Alfonso J Schmidt, Johannes U Mayer, Chun-Jen J Chen, Nathaniel Dasyam, David S Ritchie, Dale I Godfrey, Stephen R Mattarollo, P Rod Dunbar, Gavin F Painter, Ian F Hermans
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Intratumoural administration of unmethylated cytosine-phosphate-guanine motifs (CpG) to stimulate toll-like receptor (TLR)-9 has been shown to induce tumour regression in preclinical studies and some efficacy in the clinic. Because activated natural
Externí odkaz:
https://doaj.org/article/423fa268183140eca4c64e8a2ff85aed
Autor:
Olivia K Burn, Kathryn Farrand, Tara Pritchard, Sarah Draper, Ching‐wen Tang, Anna H Mooney, Alfonso J Schmidt, Sung H Yang, Geoffrey M Williams, Margaret A Brimble, Matheswaran Kandasamy, Andrew J Marshall, Kate Clarke, Gavin F Painter, Ian F Hermans, Robert Weinkove
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 7, Pp n/a-n/a (2022)
Abstract Objectives Metastasis is the principal cause of breast cancer mortality. Vaccines targeting breast cancer antigens have yet to demonstrate clinical efficacy, and there remains an unmet need for safe and effective treatment to reduce the risk
Externí odkaz:
https://doaj.org/article/3c9b77a20a6e4b3da7b8452985eb9f84
Autor:
Ellie-May Jarvis, Shaun Collings, Astrid Authier-Hall, Nathaniel Dasyam, Brendan Luey, John Nacey, Gavin F. Painter, Brett Delahunt, Ian F. Hermans, Robert Weinkove
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Prostate cancer is the second most common cancer in men worldwide. Despite an abundance of prostate-specific antigens, immunotherapies have yet to become a standard of care, potentially limited by T-cell dysfunction. Up to 10% of human circulating T-
Externí odkaz:
https://doaj.org/article/d726908ea6fa4815a7d301e76cd6be96
Autor:
Abigail V. Sharrock, Sarah P. McManaway, Michelle H. Rich, Jeff S. Mumm, Ian F. Hermans, Moana Tercel, Frederik B. Pruijn, David F. Ackerley
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Bacterial nitroreductase enzymes that can efficiently convert nitroaromatic prodrugs to a cytotoxic form have numerous applications in targeted cellular ablation. For example, the generation of cytotoxic metabolites that have low bystander potential
Externí odkaz:
https://doaj.org/article/84cc219bd1d44edcb71e6c37eef0a1bb
Autor:
Yanyan Li, Katherine Woods, Amber Parry-Strong, Regan J. Anderson, Celina Capistrano, Aurelie Gestin, Gavin F. Painter, Ian F. Hermans, Jeremy Krebs, Olivier Gasser
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The immune system plays a significant role in controlling systemic metabolism. Innate-like T (ILT) cells in particular, such as mucosal-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells and γδ T cell receptor expressing c
Externí odkaz:
https://doaj.org/article/f7bea488c2e14977bbb50c30193e257e
Autor:
Laura Ferrer-Font, Palak Mehta, Phoebe Harmos, Alfonso J Schmidt, Sally Chappell, Kylie M Price, Ian F Hermans, Franca Ronchese, Graham le Gros, Johannes U Mayer
Publikováno v:
eLife, Vol 9 (2020)
Single cell isolation from helminth-infected murine intestines has been notoriously difficult, due to the strong anti-parasite type 2 immune responses that drive mucus production, tissue remodeling and immune cell infiltration. Through the systematic
Externí odkaz:
https://doaj.org/article/24e93b44c4e44e5b843135ff7c8da27d
Publikováno v:
BMC Pulmonary Medicine, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background Asthma inflammatory phenotypes are often defined by relative cell counts of airway eosinophils/neutrophils. However, the importance of neutrophilia remains unclear, as does the effect of ICS treatment on asthma phenotypes and airw
Externí odkaz:
https://doaj.org/article/5e39a664ed0f40c59e6ec2db0a6fc618