Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Ian F Parney"'
Autor:
Svetlana Bornschlegl, Michael P Gustafson, Danae A Delivanis, Mabel Ryder, Minetta C Liu, George Vasmatzis, Chris L Hallemeier, Sean S Park, Lewis R Roberts, Ian F Parney, Diane F Jelinek, Allan B Dietz
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 4, Pp n/a-n/a (2021)
Abstract Objectives Inhibitors to the checkpoint proteins cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) and programmed cell death protein 1 (PD‐1) are becoming widely used in cancer treatment. However, a lack of understanding of the pa
Externí odkaz:
https://doaj.org/article/a9d7365d75b84bc1aac430cf1734211c
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0220569 (2019)
Abnormal activation of signal transducer and activator of transcription 3 (STAT3) transcription factor has been observed in many human cancers with roles in tumor initiation, progression, drug resistance, angiogenesis and immunosuppression. STAT3 is
Externí odkaz:
https://doaj.org/article/6e129c74f8af4aa9a29944fc190a88b1
Autor:
Ravi Kumar, Tristan de Mooij, Timothy E Peterson, Tatiana Kaptzan, Aaron J Johnson, David J Daniels, Ian F Parney
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179012 (2017)
Glioblastoma is the most common primary tumor of the brain and has few long-term survivors. The local and systemic immunosuppressive environment created by glioblastoma allows it to evade immunosurveillance. Myeloid-derived suppressor cells (MDSCs) a
Externí odkaz:
https://doaj.org/article/7efe123c08394d419710f42efd0521e5
Autor:
Julio F. Inocencio, Stefan Mitrasinovic, Mohammad Asad, Ian F. Parney, Xingxing Zang, Benjamin T. Himes
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Immune checkpoint (IC) inhibition in glioblastoma (GBM) has not shown promising results in the last decade compared to other solid tumors. Several factors contributing to the lack of immunotherapy response include the profound immunosuppressive natur
Externí odkaz:
https://doaj.org/article/d88b8cd80c534ebc81fe4e751ea86ec8
Autor:
David M. Routman, Ignacio Jusue-Torres, Paul D. Brown, Daniel M. Trifiletti, Sujay A. Vora, Desmond A. Brown, Ian F. Parney, Terry C. Burns, Elizabeth Yan
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background and Objectives Almost one third of cancer patients in the United States will develop brain metastases on an annual basis. Surgical resection is indicated in the setting of brain metastases for reasons, such as maximizing local con
Externí odkaz:
https://doaj.org/article/3a8126d4f2ad4872bf4d30a5d6f8ce1c
Autor:
Danielle N Renner, Fang Jin, Adam J Litterman, Alexis J Balgeman, Lisa M Hanson, Jeffrey D Gamez, Michael Chae, Brett L Carlson, Jann N Sarkaria, Ian F Parney, John R Ohlfest, Istvan Pirko, Kevin D Pavelko, Aaron J Johnson
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125565 (2015)
Glioblastoma (GBM) is among the most invasive and lethal of cancers, frequently infiltrating surrounding healthy tissue and giving rise to rapid recurrence. It is therefore critical to establish experimental model systems and develop therapeutic appr
Externí odkaz:
https://doaj.org/article/90232fcf3569472f97f5f1698045350b
Autor:
Evanthia Galanis, Katharine E. Dooley, S. Keith Anderson, Cheyne B. Kurokawa, Xiomara W. Carrero, Joon H. Uhm, Mark J. Federspiel, Alexey A. Leontovich, Ileana Aderca, Kimberly B. Viker, Julie E. Hammack, Randolph S. Marks, Steven I. Robinson, Derek R. Johnson, Timothy J. Kaufmann, Jan C. Buckner, Daniel H. Lachance, Terry C. Burns, Caterina Giannini, Aditya Raghunathan, Ianko D. Iankov, Ian F. Parney
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Measles virus (MV) vaccine strains have shown significant preclinical antitumor activity against glioblastoma (GBM), the most lethal glioma histology. In this first in human trial (NCT00390299), a carcinoembryonic antigen-expressing oncolyti
Externí odkaz:
https://doaj.org/article/436353bf6b554a7ca56ec210185c93df
Autor:
Dong Whan Lee, Dhivya Ramakrishnan, John Valenta, Ian F Parney, Kayla J Bayless, Raquel Sitcheran
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57489 (2013)
High-grade gliomas, such as glioblastomas (GBMs), are very aggressive, invasive brain tumors with low patient survival rates. The recent identification of distinct glioma tumor subtypes offers the potential for understanding disease pathogenesis, res
Externí odkaz:
https://doaj.org/article/b3a097573fc04604882be9741ee47b59
Autor:
Angela L M Johnston, Xueqing Lun, Jennifer J Rahn, Abdelhamid Liacini, Limei Wang, Mark G Hamilton, Ian F Parney, Barbara L Hempstead, Stephen M Robbins, Peter A Forsyth, Donna L Senger
Publikováno v:
PLoS Biology, Vol 5, Iss 8, p e212 (2007)
The invasive nature of cancers in general, and malignant gliomas in particular, is a major clinical problem rendering tumors incurable by conventional therapies. Using a novel invasive glioma mouse model established by serial in vivo selection, we id
Externí odkaz:
https://doaj.org/article/33ea284446f5469189343a2d90b1d815
Autor:
Zachariah P. Tritz, Katayoun Ayasoufi, Delaney M. Wolf, Carley A. Owens, Courtney S. Malo, Benjamin T. Himes, Cori E. Fain, Emma N. Goddery, Lila T. Yokanovich, Fang Jin, Michael J. Hansen, Ian F. Parney, Chensu Wang, Kelly D. Moynihan, Darrell J. Irvine, K. Dane Wittrup, Rosa M. Diaz Marcano, Richard G. Vile, Aaron J. Johnson
Publikováno v:
Cancer Immunology Research. :OF1-OF14
Glioblastoma (GBM) is the most common malignant brain tumor in adults, responsible for approximately 225,000 deaths per year. Despite preclinical successes, most interventions have failed to extend patient survival by more than a few months. Treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7540cd53a24c6bdfa3312e808dfa839f
https://doi.org/10.1158/2326-6066.cir-22-0570
https://doi.org/10.1158/2326-6066.cir-22-0570