Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ian E Gentle"'
Autor:
Katharine J Goodall, Megan L Finch-Edmondson, Joanne van Vuuren, George C Yeoh, Ian E Gentle, James E Vince, Paul G Ekert, David L Vaux, Bernard A Callus
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0164003 (2016)
Apoptosis mediated by Bax or Bak is usually thought to be triggered by BH3-only members of the Bcl-2 protein family. BH3-only proteins can directly bind to and activate Bax or Bak, or indirectly activate them by binding to anti-apoptotic Bcl-2 family
Externí odkaz:
https://doaj.org/article/10cbdea384e44e65aaebf41fbee23257
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Abstract Regulated cell death frequently occurs upon infection by intracellular pathogens, and extent and regulation is often cell-type-specific. We aimed to identify the cell death-signaling pathways triggered in macrophages by infection with modifi
Externí odkaz:
https://doaj.org/article/60e2a85296fe4c9a9862e99e0ddca3a6
Autor:
Simon Lagies, Daqiang Pan, Daniel A. Mohl, Dietmar A. Plattner, Ian E. Gentle, Bernd Kammerer
Publikováno v:
Cells, Vol 12, Iss 5, p 692 (2023)
Metabolomics has expanded from cellular to subcellular level to elucidate subcellular compartmentalization. By applying isolated mitochondria to metabolome analysis, the hallmark of mitochondrial metabolites has been unraveled, showing compartment-sp
Externí odkaz:
https://doaj.org/article/261552876e524516a6e77063649c5715
Autor:
George C.T. Yeoh, David L. Vaux, Paul G Ekert, James E Vince, Joanne H. van Vuuren, Megan Finch-Edmondson, Bernard A. Callus, Katharine J. Goodall, Ian E Gentle
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0164003 (2016)
PLoS ONE
PLoS ONE
Apoptosis mediated by Bax or Bak is usually thought to be triggered by BH3-only members of the Bcl-2 protein family. BH3-only proteins can directly bind to and activate Bax or Bak, or indirectly activate them by binding to anti-apoptotic Bcl-2 family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c6cc591fdc88f2734d87e3bff47b7d
Publikováno v:
J Virol
The mitochondrial apoptosis pathway has the function to kill the cell, but recent work shows that this pathway can also be activated to a sublethal level, where signal transduction can be observed but the cell survives. Intriguingly, this signaling h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fcc8f6e6ad4e156ed97d6ccb4f2ca5
https://doi.org/10.1128/jvi.01212-22
https://doi.org/10.1128/jvi.01212-22
Publikováno v:
EMBO reports. 23(8)
GM-CSF is a potent inflammatory cytokine regulating myeloid cell differentiation, hematopoiesis, and various other functions. It is functionally associated with a number of inflammatory pathologies including rheumatoid arthritis and inflammatory bowe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e9dd61f026b495184a08d4d591c716
https://pubmed.ncbi.nlm.nih.gov/35695080
https://pubmed.ncbi.nlm.nih.gov/35695080
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Regulated cell death frequently occurs upon infection by intracellular pathogens, and extent and regulation is often cell-type-specific. We aimed to identify the cell death-signaling pathways triggered in macrophages by infection with modified vaccin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3a726516bff764b680808918c3cc94
http://europepmc.org/articles/PMC8551665
http://europepmc.org/articles/PMC8551665
Autor:
Tanel Mahlakõiv, Stefan T. Peterson, Laure Dumoutier, Ian E Gentle, Peter Staeheli, Celso A. Reis, Meagan E Sullender, Camille Michiels, Pedro P. Hernandez, Annette Ohnemus, Megan T. Baldridge, Stefania Crotta, Andreas Diefenbach, Andreas Wack, Daniel Schnepf
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0247738 (2021)
PLoS ONE
PloS one, Vol. 16, no.8, p. e0247738 (2021)
PLoS ONE
PloS one, Vol. 16, no.8, p. e0247738 (2021)
The commensal microbiota regulates susceptibility to enteric pathogens by fine-tuning mucosal innate immune responses, but how susceptibility to enteric viruses is shaped by the microbiota remains incompletely understood. Past reports have indicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b108ae53167508f0d332d17c65e9b13
https://doi.org/10.1371/journal.pone.0247738
https://doi.org/10.1371/journal.pone.0247738
Autor:
Arlena Metz, Ian E Gentle, Oliver Kretz, Kevin T. McHenry, Georg Häcker, Dale Porter, Arnim Weber
Publikováno v:
The FEBS Journal. 284:1987-2003
The formation of amyloid-like protein structures has recently emerged as a feature in signal transduction, particularly in innate immunity. These structures appear to depend on defined domains for their formation but likely also require dedicated way
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a212e86c5621d99c64fc87ff0021ceb8
https://doi.org/10.1111/febs.14091
https://doi.org/10.1111/febs.14091
Autor:
Julia Henschel, Dominik Brokatzky, Arnim Weber, Juliane Vier, Aladin Haimovici, Arlena Metz, Georg Häcker, Benedikt Dörflinger, Susanne Kirschnek, Tobias Steinfeldt, Ian E Gentle
Publikováno v:
EMBO J
Apoptosis is a frequent form of programmed cell death, but the apoptotic signaling pathway can also be engaged at a low level, in the absence of cell death. We here report that such sub-lethal engagement of mitochondrial apoptosis signaling causes th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc8d5e8e6dd8c5431fbde825ffef837
https://europepmc.org/articles/PMC6545560/
https://europepmc.org/articles/PMC6545560/