Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ian Diner"'
Autor:
Lake Rabenold, Duc M. Duong, Isaac Bishof, Juan C. Troncoso, Madhav Thambisetty, Ian Diner, Nicholas T. Seyfried, James J. Lah, Oskar Laur, Allan I. Levey, Chadwick M. Hales, Hong Yi, Marla Gearing
Publikováno v:
Journal of Biological Chemistry. 289:35296-35313
Recent evidence indicates that U1-70K and other U1 small nuclear ribonucleoproteins are Sarkosyl-insoluble and associate with Tau neurofibrillary tangles selectively in Alzheimer disease (AD). Currently, the mechanisms underlying the conversion of so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e272d45de8b90906c90cd1df449d11
https://doi.org/10.1074/jbc.m114.562959
https://doi.org/10.1074/jbc.m114.562959
Publikováno v:
Journal of visualized experiments : JoVE. (128)
In this study, we describe an abbreviated single-step fractionation protocol for the enrichment of detergent-insoluble protein aggregates from human postmortem brain. The ionic detergent N-lauryl-sarcosine (sarkosyl) effectively solubilizes natively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2eb6b81b9e5465138638a086e39697f
https://pubmed.ncbi.nlm.nih.gov/29155708
https://pubmed.ncbi.nlm.nih.gov/29155708
Autor:
Thomas J. Montine, Jonathan D. Glass, Eric B. Dammer, Allan I. Levey, Nicholas T. Seyfried, James J. Lah, Ian Diner, Chadwick M. Hales, Marla Gearing, Hong Yi
Publikováno v:
Brain Pathology. 24:344-351
We recently discovered that protein components of the ribonucleic acid (RNA) spliceosome form cytoplasmic aggregates in Alzheimer's disease (AD) brain, resulting in widespread changes in RNA splicing. However, the involvement of small nuclear RNAs (s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1c633cd5a56db0645ffd2fa722e6643
https://doi.org/10.1111/bpa.12133
https://doi.org/10.1111/bpa.12133
Autor:
Yue Feng, James J. Lah, Duc M. Duong, Marla Gearing, Ian Diner, Nicholas T. Seyfried, Eric B. Dammer, Allan I. Levey
Publikováno v:
Journal of Proteome Research. 12:3193-3206
The brain consists of diverse cell types including neurons, astrocytes, oligodendrocytes and microglia. The isolation of nuclei from these distinct cell populations provides an opportunity to identify cell-type specific nuclear proteins, histone modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f815a27d90c295b2359b86c232742f46
https://doi.org/10.1021/pr400246t
https://doi.org/10.1021/pr400246t
Publikováno v:
The FASEB Journal. 29
The RNA binding protein U1-70K aggregates via an unknown mechanism in Alzheimer's disease (AD). Interestingly, AD brain homogenates can induce the aggregation of soluble U1-70K from control brain o...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b68772798e4e4e3add3b073dbb2cb138
https://doi.org/10.1096/fasebj.29.1_supplement.712.3
https://doi.org/10.1096/fasebj.29.1_supplement.712.3
Autor:
Chadwick M, Hales, Eric B, Dammer, Ian, Diner, Hong, Yi, Nicholas T, Seyfried, Marla, Gearing, Jonathan D, Glass, Thomas J, Montine, Allan I, Levey, James J, Lah
Publikováno v:
Brain pathology (Zurich, Switzerland). 24(4)
We recently discovered that protein components of the ribonucleic acid (RNA) spliceosome form cytoplasmic aggregates in Alzheimer’s disease (AD) brain, resulting in widespread changes in RNA splicing. However, the involvement of small nuclear RNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::19c30171b491a79a377669cce2a83a2f
https://pubmed.ncbi.nlm.nih.gov/24571648
https://pubmed.ncbi.nlm.nih.gov/24571648