Repeat controlled human malaria infection of healthy UK adults with blood-stage Plasmodium falciparum: Safety and parasite growth dynamics

Autor: Jo Salkeld, Yrene Themistocleous, Jordan R. Barrett, Celia H. Mitton, Thomas A. Rawlinson, Ruth O. Payne, Mimi M. Hou, Baktash Khozoee, Nick J. Edwards, Carolyn M. Nielsen, Diana Muñoz Sandoval, Florian A. Bach, Wiebke Nahrendorf, Raquel Lopez Ramon, Megan Baker, Fernando Ramos-Lopez, Pedro M. Folegatti, Doris Quinkert, Katherine J. Ellis, Ian D. Poulton, Alison M. Lawrie, Jee-Sun Cho, Fay L. Nugent, Philip J. Spence, Sarah E. Silk, Simon J. Draper, Angela M. Minassian

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

In endemic settings it is known that natural malaria immunity is gradually acquired following repeated exposures. Here we sought to assess whether similar acquisition of blood-stage malaria immunity would occur following repeated parasite exposure by

Externí odkaz: https://doaj.org/article/e073d6a50a334532bed97edf79803bd5

Safety and Immunogenicity of ChAd63/MVA Pfs25-IMX313 in a Phase I First-in-Human Trial

Autor: Hans de Graaf, Ruth O. Payne, Iona Taylor, Kazutoyo Miura, Carol A. Long, Sean C. Elias, Marija Zaric, Angela M. Minassian, Sarah E. Silk, Lee Li, Ian D. Poulton, Megan Baker, Simon J. Draper, Diane Gbesemete, Nathan J. Brendish, Filipa Martins, Arianna Marini, David Mekhaiel, Nick J. Edwards, Rachel Roberts, Johan Vekemans, Sarah Moyle, Saul N. Faust, Eleanor Berrie, Alison M. Lawrie, Fergal Hill, Adrian V. S. Hill, Sumi Biswas

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

BackgroundTransmission blocking vaccines targeting the sexual-stages of the malaria parasite could play a major role to achieve elimination and eradication of malaria. The Plasmodium falciparum Pfs25 protein (Pfs25) is the most clinically advanced ca

Externí odkaz: https://doaj.org/article/daf9bdd8e4a1400a9c2b0c0584c0a152

Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Naïve and Vaccinated Hosts.

Autor: Thomas S Churcher, Robert E Sinden, Nick J Edwards, Ian D Poulton, Thomas W Rampling, Patrick M Brock, Jamie T Griffin, Leanna M Upton, Sara E Zakutansky, Katarzyna A Sala, Fiona Angrisano, Adrian V S Hill, Andrew M Blagborough

Publikováno v: PLoS Pathogens, Vol 13, Iss 1, p e1006108 (2017)

Over a century since Ronald Ross discovered that malaria is caused by the bite of an infectious mosquito it is still unclear how the number of parasites injected influences disease transmission. Currently it is assumed that all mosquitoes with saliva

Externí odkaz: https://doaj.org/article/06b851e695e24547811f54f463879571

Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly

Autor: Geneviève M. Labbé, Eerik Aunin, Yrene Themistocleous, Jee Sun Cho, Raquel Lopez Ramon, Julian C. Rayner, Baktash Khozoee, Chayanut Suansomjit, Sarah E. Silk, Doris Quinkert, Alison Kemp, Thomas D. Otto, Iona J. Taylor, Alison M. Lawrie, Simon J. Draper, Angela M. Minassian, Thomas A. Rawlinson, Marija Zaric, Celia Mitton, Jason C. Sousa, Jetsumon Sattabongkot, Andrew M. Blagborough, Sumi Biswas, Kimberly J. Johnson, Florian Bach, Chalermpon Kumpitak, Adam J. Reid, Margaux Mulatier, Nongnuj Maneechai, Ian D. Poulton, Katherine J. Ellis, Nattawan Rachaphaew, Nick J. Edwards, Fernando Ramos Lopez, Philip J Spence, Carolyn M. Nielsen, Wanlapa Roobsoong, Arianna Marini, Kirsty McHugh, Megan Baker, David J. Roberts, Mimi M. Hou, Tianrat Piteekan, Jordan R. Barrett, Fay L. Nugent

Publikováno v: Minassian, A M, Themistocleous, Y, Silk, S E, Barrett, J R, Kemp, A, Quinkert, D, Nielsen, C M, Edwards, N J, Rawlinson, T A, Ramos Lopez, F, Roobsoong, W, Ellis, K J D, Cho, J-S, Aunin, E, Otto, T D, Reid, A J, Bach, F A, Labbé, G M C, Poulton, I D, Marini, A, Zaric, M, Mulatier, M, Lopez Ramon, R, Baker, M, Mitton, C H, Sousa, J C, Rachaphaew, N, Kumpitak, C, Maneechai, N, Suansomjit, C, Piteekan, T, Hou, M M, Khozoee, B, McHugh, K, Roberts, D J, Lawrie, A M, Blagborough, A M, Nugent, F L, Taylor, I J, Johnson, K J, Spence, P J, Sattabongkot, J, Biswas, S, Rayner, J C & Draper, S J 2021, ' Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly ', JCI Insight, vol. 6, no. 23, e152465 . https://doi.org/10.1172/jci.insight.152465
JCI Insight

Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum, well-charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc190240819a778fd98762e57e377c28
https://doi.org/10.1172/jci.insight.152465

A single dose of ChAdOx1 Chik vaccine induces neutralising antibodies against four chikungunya virus lineages in a phase 1 clinical trial

Autor: Fernando Ramos Lopez, Alison M. Lawrie, Nguyen Tran, Amy Flaxman, Adrian V. S. Hill, P M Folegatti, M Bittaye, Lorena Preciado-Llanes, Sasha R. Azar, Ian D. Poulton, R Makinson, Young Chan Kim, Shannan L. Rossi, Katie J. Ewer, Kate Harrison, Rafael K. Campos, D Jenkin, Jonathan Sheridan, Mark Tilley, Eleanor Berrie, Arturo Reyes-Sandoval, Rachel Roberts, D Bellamy

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications

Chikungunya virus (CHIKV) is a reemerging mosquito-borne virus that causes swift outbreaks. Major concerns are the persistent and disabling polyarthralgia in infected individuals. Here we present the results from a first-in-human trial of the candida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731cd1326dad67f34434a3b0adc4bdef
https://ora.ox.ac.uk/objects/uuid:392ef680-ccfc-4eee-a066-312181e544c7