Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ian D. Daugs"'
Autor:
Alex E Roher, David H Cribbs, Ronald C Kim, Chera L Maarouf, Charisse M Whiteside, Tyler A Kokjohn, Ian D Daugs, Elizabeth Head, Carolyn Liebsack, Geidy Serrano, Christine Belden, Marwan N Sabbagh, Thomas G Beach
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59735 (2013)
The characteristic neuropathological changes associated with Alzheimer's disease (AD) and other lines of evidence support the amyloid cascade hypothesis. Viewing amyloid deposits as the prime instigator of dementia has now led to clinical trials of m
Externí odkaz:
https://doaj.org/article/e1f712923df14ed6badcf2a6efbd1aa7
Autor:
Chera L Maarouf, Ian D Daugs, Tyler A Kokjohn, Douglas G Walker, Jesse M Hunter, Jane C Kruchowsky, Randy Woltjer, Jeffrey Kaye, Eduardo M Castaño, Marwan N Sabbagh, Thomas G Beach, Alex E Roher
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27291 (2011)
The amyloid cascade hypothesis provides an economical mechanistic explanation for Alzheimer's disease (AD) dementia and correlated neuropathology. However, some nonagenarian individuals (high pathology controls, HPC) remain cognitively intact while e
Externí odkaz:
https://doaj.org/article/67725ef0a8a346f5a8e6df781ffcb964
Autor:
Jesse M. Hunter, Emma Rodriguez, Walter M. Kalback, Michael Malek-Ahmadi, Alex E. Roher, Ian D. Daugs, Marwan N. Sabbagh, Tyler A. Kokjohn, Thomas G. Beach, Charisse M. Whiteside, Sandra Jacobson, Chera L. Maarouf
Publikováno v:
Journal of Neurotrauma. 30:981-997
Dementia pugilistica (DP), a suite of neuropathological and cognitive function declines after chronic traumatic brain injury (TBI), is present in approximately 20% of retired boxers. Epidemiological studies indicate TBI is a risk factor for neurodege
Autor:
John Lopez, Tyler A. Kokjohn, Alex E. Roher, Ian D. Daugs, Lucia I. Sue, Dean C. Luehrs, Jesse M. Hunter, Walter M. Kalback, Eduardo M. Castaño, Thomas G. Beach, Gregory D. Van Vickle, Chera L. Maarouf, Daniel C. Brune
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1812:1508-1514
Amyloid-β (Aβ) peptides are intimately involved in the inflammatory pathology of atherosclerotic vascular disease (AVD) and Alzheimer's disease (AD). Although substantial amounts of these peptides are produced in the periphery, their role and signi
Autor:
Jesse M. Hunter, Tyler A. Kokjohn, Ian D. Daugs, Thomas G. Beach, Alex E. Roher, Marwan N. Sabbagh, Chera L. Maarouf
Publikováno v:
Journal of Alzheimer's Disease. 24:315-325
The field of Alzheimer's disease (AD) research eagerly awaits the results of a large number of Phase III clinical trials that are underway to investigate the effectiveness of anti-amyloid-β (Aβ) immunotherapy for AD. In this case report, we review
Autor:
Tyler A. Kokjohn, Marek Belohlavek, Ian D. Daugs, Lucia I. Sue, Chera L. Maarouf, Marwan N. Sabbagh, Mark R. Emmerling, Alex E. Roher, Suzanne L. Tyas, Thomas G. Beach, Zsolt Garami
Publikováno v:
Alzheimer's & Dementia. 7:436-444
Background A substantial body of evidence collected from epidemiologic, correlative, and experimental studies strongly associates atherosclerotic vascular disease (AVD) with Alzheimer's disease (AD). Depending on the precise interrelationship between
Autor:
Dean C. Luehrs, Chera Esh, Thomas G. Beach, Walter M. Kalback, Douglas G. Walker, Eduardo M. Castaño, Alex E. Roher, Judianne Davis, Gregory D. Van Vickle, Lih-Fen Lue, Ian D. Daugs, Tyler A. Kokjohn, William E. Van Nostrand, R. Lyle Patton
Publikováno v:
The American Journal of Pathology. 173:483-493
Alzheimer's disease (AD) is characterized by the accumulation of extracellular insoluble amyloid, primarily derived from polymerized amyloid-beta (Abeta) peptides. We characterized the chemical composition of the Abeta peptides deposited in the brain
Autor:
Alex E, Roher, Chera L, Maarouf, Michael, Malek-Ahmadi, Jeffrey, Wilson, Tyler A, Kokjohn, Ian D, Daugs, Charisse M, Whiteside, Walter M, Kalback, Mimi P, Macias, Sandra A, Jacobson, Marwan N, Sabbagh, Bernardino, Ghetti, Thomas G, Beach
Publikováno v:
American journal of neurodegenerative disease. 2(3)
Alzheimer’s disease (AD) dementia impacts all facets of higher order cognitive function and is characterized by the presence of distinctive pathological lesions in the gray matter (GM). The profound alterations in GM structure and function have fos
Autor:
Geidy E. Serrano, Ian D. Daugs, David H. Cribbs, Elizabeth Head, Carolyn Liebsack, Marwan N. Sabbagh, Alex E. Roher, Ronald C. Kim, Charisse M. Whiteside, Chera L. Maarouf, Tyler A. Kokjohn, Thomas G. Beach, Christine Belden
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59735 (2013)
PLoS ONE
PLoS ONE
The characteristic neuropathological changes associated with Alzheimer's disease (AD) and other lines of evidence support the amyloid cascade hypothesis. Viewing amyloid deposits as the prime instigator of dementia has now led to clinical trials of m
Autor:
Alex E. Roher, Jesse M. Hunter, Chera L. Maarouf, Ian D. Daugs, Marwan N. Sabbagh, Douglas G. Walker, Thomas G. Beach, Tyler A. Kokjohn, Eric M. Reiman
Publikováno v:
Alzheimer's & Dementia. 8