Výsledky vyhledávání - "Ian D. Collier"

Concise routes to pyrazolo[1,5-a]pyridin-3-yl pyridazin-3-ones

Autor: Robert W. Allcock, Yasushi Kohno, David R. Adams, Keith M. Morgan, Ian D. Collier, Patrick D. Bailey, Georgina M. Rosair, Karen A. Johnston, Haakon Blakli, Zhong Jiang

Publikováno v: Org. Biomol. Chem.. 6:175-186

Cycloaddition of pyridine N-imine with 6-alkyl-4-oxohex-5-ynoates followed by condensation with hydrazine provides concise access to pharmacologically active 6-(pyrazolo[1,5-a]pyridin-3-yl)pyridazinones. For the first time alkynyl heterocycles are al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a222786961860dcb76d2e5c5caffbed0
https://doi.org/10.1039/b713638b

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Identification of a candidate membrane protein for the basolateral peptide transporter of rat small intestine

Autor: Norma Lister, George L. Kellett, Patrick D. Bailey, J R Bronk, C. A. R. Boyd, E. J. Shepherd, Ian D. Collier, Julie Affleck

Publikováno v: Biochemical and Biophysical Research Communications. 296:918-922

A candidate protein for the basolateral peptide transporter of rat jejunum is described. Vascular perfusion of the photoaffinity label, [4-azido-D-phe]-L-ala (2.5mM), had no effect on the transepithelial transport of the non-hydrolysable dipeptide D-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fae3fbbe38410aa870bc2ba84b2641
https://doi.org/10.1016/s0006-291x(02)02021-1

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Modified amino acids and peptides as substrates for the intestinal peptide transporter PepT1

Autor: Corinna J. Sword, Nishan Guha, Keith M. Morgan, Ian D. Collier, David Meredith, C S Temple, Patrick D. Bailey, C. A. Richard Boyd

Publikováno v: European Journal of Biochemistry. 267:3723-3728

The binding affinities of a number of amino-acid and peptide derivatives by the mammalian intestinal peptide transporter PepT1 were investigated, using the Xenopus laevis expression system. A series of blocked amino acids, namely N-acetyl-Phe (Ac-Phe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9becb5e5f572246f38af7e257a83d50
https://doi.org/10.1046/j.1432-1327.2000.01405.x

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How to Make Drugs Orally Active: A Substrate Template for Peptide Transporter PepT1

Autor: J. Ramsey Bronk, C S Temple, Keith M. Morgan, Ian D. Collier, Patrick D. Bailey, David Meredith, C. A. Richard Boyd

Publikováno v: Angewandte Chemie. 112:515-518

By building key structural features into hydrophilic drugs, they can be recognized by the PepT1 transporter system of the small intestine and rendered orally active. The model shown provides, for the first time, a 3D template for all known substrates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe3c0f073702651ddcac32338dc054c
https://doi.org/10.1002/(sici)1521-3757(20000204)112:3<515::aid-ange515>3.0.co

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4-Aminomethylbenzoic acid is a non-translocated competitive inhibitor of the epithelial peptide transporter PepT1

Autor: J R Bronk, David Meredith, C S Temple, Keith M. Morgan, Ian D. Collier, C. A. R. Boyd, Patrick D. Bailey

Publikováno v: The Journal of Physiology. 512:629-634

1. 4-Aminomethylbenzoic acid, a molecule which mimics the special configuration of a dipeptide, competitively inhibits peptide influx in both Xenopus Laevis oocytes expressing rabbit PepT1 and through PepT1 in rat renal brush border membrane vesicles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c98231a73739696580e9117fc2a5202
https://doi.org/10.1111/j.1469-7793.1998.629bd.x

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Affinity prediction for substrates of the peptide transporter PepT1

Autor: C. A. Richard Boyd, Patrick D. Bailey, John. P. George, David Meredith, Richard A. Price, Keith M. Morgan, Ian D. Collier, Rachel Pettecrew, George L. Kellett

Publikováno v: Chem. Commun.. :323-325

A quantitative method has been developed for determining the affinity of substrates for the peptide transporter PepT1, allowing oral availability of drugs via PepT1 to be estimated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03379473e0d1c3cbedf3f79f53c51f6
https://doi.org/10.1039/b511996k

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The influence of luminal pH on transport of neutral and charged dipeptides by rat small intestine, in vitro

Autor: J. Ramsey Bronk, Patrick D. Bailey, Ian D. Collier, Norma Lister, C. A. Richard Boyd

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1324(2):245-250

Four hydrolysis-resistant dipeptides (D-phenylalanyl-L-alanine, D-phenylalanyl-L-glutamine, D-phenylalanyl-L-glutamate and D-phenylalanyl-L-lysine) were synthesized to investigate the effects of net charge on transmural dipeptide transport by isolate

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New asymmetric route to bridged indole alkaloids: formal enantiospecific syntheses of (−)-suaveoline, (−)-raumacline and (−)-N b-methylraumacline

Autor: David I. Smith, Keith M. Morgan, Ian D. Collier, Sean P. Hollinshead, Patrick D. Bailey, Madeleine H. Moore, John M. Vernon

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :1209-1214

The homologous nitrile 13 derived from L-tryptophan undergoes a modified Pictet–Spengler reaction with methyl propynoate, under conditions of kinetic control, to afford the cis-tetrahydro-β-carboline 15a (cis∶trans = 77∶23). After protection,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc86fee79dfaec902b533030bb362c0f
https://doi.org/10.1039/a606081a

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A concise, efficient route to fumitremorgins

Autor: Patrick D. Bailey, David P. J. Pearson, Katrin Lorenz, Ian D. Collier, Georgina M. Rosair, Philip J. Cochrane

Publikováno v: Tetrahedron Letters. 42:113-115

Using the kinetically controlled Pictet–Spengler reaction, we have developed a three-step, diastereoselective and enantiospecific synthesis of the natural product demethoxy-fumitremorgin C in 21% overall yield.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c3097c0edcb00ca0d5af2372559b695
https://doi.org/10.1016/s0040-4039(00)01899-2

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