Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Ian D. Collier"'
Autor:
Robert W. Allcock, Yasushi Kohno, David R. Adams, Keith M. Morgan, Ian D. Collier, Patrick D. Bailey, Georgina M. Rosair, Karen A. Johnston, Haakon Blakli, Zhong Jiang
Publikováno v:
Org. Biomol. Chem.. 6:175-186
Cycloaddition of pyridine N-imine with 6-alkyl-4-oxohex-5-ynoates followed by condensation with hydrazine provides concise access to pharmacologically active 6-(pyrazolo[1,5-a]pyridin-3-yl)pyridazinones. For the first time alkynyl heterocycles are al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a222786961860dcb76d2e5c5caffbed0
https://doi.org/10.1039/b713638b
https://doi.org/10.1039/b713638b
Autor:
Norma Lister, George L. Kellett, Patrick D. Bailey, J R Bronk, C. A. R. Boyd, E. J. Shepherd, Ian D. Collier, Julie Affleck
Publikováno v:
Biochemical and Biophysical Research Communications. 296:918-922
A candidate protein for the basolateral peptide transporter of rat jejunum is described. Vascular perfusion of the photoaffinity label, [4-azido-D-phe]-L-ala (2.5mM), had no effect on the transepithelial transport of the non-hydrolysable dipeptide D-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fae3fbbe38410aa870bc2ba84b2641
https://doi.org/10.1016/s0006-291x(02)02021-1
https://doi.org/10.1016/s0006-291x(02)02021-1
Autor:
Corinna J. Sword, Nishan Guha, Keith M. Morgan, Ian D. Collier, David Meredith, C S Temple, Patrick D. Bailey, C. A. Richard Boyd
Publikováno v:
European Journal of Biochemistry. 267:3723-3728
The binding affinities of a number of amino-acid and peptide derivatives by the mammalian intestinal peptide transporter PepT1 were investigated, using the Xenopus laevis expression system. A series of blocked amino acids, namely N-acetyl-Phe (Ac-Phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9becb5e5f572246f38af7e257a83d50
https://doi.org/10.1046/j.1432-1327.2000.01405.x
https://doi.org/10.1046/j.1432-1327.2000.01405.x
Autor:
J. Ramsey Bronk, C S Temple, Keith M. Morgan, Ian D. Collier, Patrick D. Bailey, David Meredith, C. A. Richard Boyd
Publikováno v:
Angewandte Chemie. 112:515-518
By building key structural features into hydrophilic drugs, they can be recognized by the PepT1 transporter system of the small intestine and rendered orally active. The model shown provides, for the first time, a 3D template for all known substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe3c0f073702651ddcac32338dc054c
https://doi.org/10.1002/(sici)1521-3757(20000204)112:3<515::aid-ange515>3.0.co
https://doi.org/10.1002/(sici)1521-3757(20000204)112:3<515::aid-ange515>3.0.co
Autor:
J R Bronk, David Meredith, C S Temple, Keith M. Morgan, Ian D. Collier, C. A. R. Boyd, Patrick D. Bailey
Publikováno v:
The Journal of Physiology. 512:629-634
1. 4-Aminomethylbenzoic acid, a molecule which mimics the special configuration of a dipeptide, competitively inhibits peptide influx in both Xenopus Laevis oocytes expressing rabbit PepT1 and through PepT1 in rat renal brush border membrane vesicles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c98231a73739696580e9117fc2a5202
https://doi.org/10.1111/j.1469-7793.1998.629bd.x
https://doi.org/10.1111/j.1469-7793.1998.629bd.x
Autor:
C. A. Richard Boyd, Patrick D. Bailey, John. P. George, David Meredith, Richard A. Price, Keith M. Morgan, Ian D. Collier, Rachel Pettecrew, George L. Kellett
Publikováno v:
Chem. Commun.. :323-325
A quantitative method has been developed for determining the affinity of substrates for the peptide transporter PepT1, allowing oral availability of drugs via PepT1 to be estimated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03379473e0d1c3cbedf3f79f53c51f6
https://doi.org/10.1039/b511996k
https://doi.org/10.1039/b511996k
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1324(2):245-250
Four hydrolysis-resistant dipeptides (D-phenylalanyl-L-alanine, D-phenylalanyl-L-glutamine, D-phenylalanyl-L-glutamate and D-phenylalanyl-L-lysine) were synthesized to investigate the effects of net charge on transmural dipeptide transport by isolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a6d792141e42e56a9b20397b2f61cd
Autor:
David I. Smith, Keith M. Morgan, Ian D. Collier, Sean P. Hollinshead, Patrick D. Bailey, Madeleine H. Moore, John M. Vernon
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1209-1214
The homologous nitrile 13 derived from L-tryptophan undergoes a modified Pictet–Spengler reaction with methyl propynoate, under conditions of kinetic control, to afford the cis-tetrahydro-β-carboline 15a (cis∶trans = 77∶23). After protection,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc86fee79dfaec902b533030bb362c0f
https://doi.org/10.1039/a606081a
https://doi.org/10.1039/a606081a
Autor:
Patrick D. Bailey, David P. J. Pearson, Katrin Lorenz, Ian D. Collier, Georgina M. Rosair, Philip J. Cochrane
Publikováno v:
Tetrahedron Letters. 42:113-115
Using the kinetically controlled Pictet–Spengler reaction, we have developed a three-step, diastereoselective and enantiospecific synthesis of the natural product demethoxy-fumitremorgin C in 21% overall yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c3097c0edcb00ca0d5af2372559b695
https://doi.org/10.1016/s0040-4039(00)01899-2
https://doi.org/10.1016/s0040-4039(00)01899-2
Autor:
Madeleine H. Moore, John M. Vernon, Keith M. Morgan, Patrick D. Bailey, Ian D. Collier, David I. Smith, S. P. Hollinshead
Publikováno v:
ChemInform. 25
When the homologated nitrile 11 derived from L-tryptophan undergoes a modified Pictet–Spengler reaction with methyl propynoate, the resulting cis-tetrahydro-β-carboline 12a is ideally functionalised for cyclisation to the bridged ketonitrile 14; s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd783940726bbf342539d3856cf1bfef
https://doi.org/10.1002/chin.199447243
https://doi.org/10.1002/chin.199447243