Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ian D Manger"'
Autor:
Peter B Madrid, Sidharth Chopra, Ian D Manger, Lynne Gilfillan, Tiffany R Keepers, Amy C Shurtleff, Carol E Green, Lalitha V Iyer, Holli Hutcheson Dilks, Robert A Davey, Andrey A Kolokoltsov, Ricardo Carrion, Jean L Patterson, Sina Bavari, Rekha G Panchal, Travis K Warren, Jay B Wells, Walter H Moos, Raelyn L Burke, Mary J Tanga
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60579 (2013)
BACKGROUND: The rapid development of effective medical countermeasures against potential biological threat agents is vital. Repurposing existing drugs that may have unanticipated activities as potential countermeasures is one way to meet this importa
Externí odkaz:
https://doaj.org/article/8f664db31ceb45f1adcae9b7d13042df
Autor:
Mary J. Tanga, Amy C. Shurtleff, Lynne Gilfillan, Sina Bavari, Travis K. Warren, Peter B. Madrid, Robert A. Davey, Aaron N. Endsley, Andrey A. Kolokoltsov, Ian D. Manger, Carol E. Green, Rekha G. Panchal
Publikováno v:
ACS Infectious Diseases. 1:317-326
A systematic screen of FDA-approved drugs was performed to identify compounds with in vitro antiviral activities against Ebola virus (EBOV). Compounds active (>50% viral inhibition and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddbd0eb52a1a645e6bb0ed82376bac8
https://doi.org/10.1021/acsinfecdis.5b00030
https://doi.org/10.1021/acsinfecdis.5b00030
Publikováno v:
Drug Development Research. 70:327-334
In spite of significant increases in biodefense spending in the 7 years since the 2001 anthrax attacks, the United States may not yet be fully prepared to respond effectively to many potential biothreats. The principal reasons appear to be that: (1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dd4da6db13baccf50c4f897d94297cf
https://doi.org/10.1002/ddr.20309
https://doi.org/10.1002/ddr.20309
Targeted disruption of an essential RNA-binding protein perturbs cell division in Trypanosoma brucei
Autor:
John C. Boothroyd, Ian D. Manger
Publikováno v:
Molecular and Biochemical Parasitology. 116:239-245
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d3039c96f491dbec8c2a8857273eae
https://doi.org/10.1016/s0166-6851(01)00322-x
https://doi.org/10.1016/s0166-6851(01)00322-x
Publikováno v:
Journal of Biological Chemistry. 276:24223-24231
Cells infected with the intracellular protozoan parasite Toxoplasma gondii undergo up-regulation of pro-inflammatory cytokines, organelle redistribution, and protection from apoptosis. To examine the molecular basis of these and other changes, gene e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4ccc28c0d37ff2b8e89a7f017a86b6
https://doi.org/10.1074/jbc.m100951200
https://doi.org/10.1074/jbc.m100951200
Autor:
David A. Relman, Ian D. Manger
Publikováno v:
Current Opinion in Immunology. 12:215-218
Innate immune responses to pathogens are believed to be patterned and stereotyped. Adaptive responses display variety but in relatively few types of products and with limited numbers of mechanisms. Is this apparent disparity between microbial pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f11711046ad0d8134a86df5a3c1e35
https://doi.org/10.1016/s0952-7915(99)00077-1
https://doi.org/10.1016/s0952-7915(99)00077-1
Publikováno v:
Infection and Immunity. 66:2237-2244
Toxoplasma gondii is an Apicomplexan parasite with a complex life cycle that includes a rapidly dividing asexual stage known as the tachyzoite. The tachyzoite surface has been reported to comprise five major antigens, the most abundant of which is de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fef53960d47f4621a3fa06c14046bf6
https://doi.org/10.1128/iai.66.5.2237-2244.1998
https://doi.org/10.1128/iai.66.5.2237-2244.1998
Autor:
LaDeana W. Hillier, Ian D. Manger, Steve F. Parmley, Adrian B. Hehl, L. David Sibley, Marco A. Marra, Robert H. Waterston, John C. Boothroyd
Publikováno v:
Scopus-Elsevier
Toxoplasma gondii is a protozoan parasite responsible for widespread infections in humans and animals. Two major asexual forms are produced during the life cycle of this parasite: the rapidly dividing tachyzoite and the more slowly dividing, encysted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2048ce6ecad7a52d69aa5f5e5f2c4ded
https://doi.org/10.1128/iai.66.4.1632-1637.1998
https://doi.org/10.1128/iai.66.4.1632-1637.1998
Publikováno v:
International Journal for Parasitology. 28:3-9
As for any intracellular parasite, the surface of the Apicomplexan parasite Toxoplasma gondii must fulfil many functions including a role in attachment, signalling, invasion, transport and interaction with the immune response of the host. In this rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0855d9e8697635de7539f13fdfbcabab
https://doi.org/10.1016/s0020-7519(97)00182-3
https://doi.org/10.1016/s0020-7519(97)00182-3
Autor:
Robert A. Davey, Travis K. Warren, Jean L. Patterson, Rekha G. Panchal, Jay Wells, Mary J. Tanga, Sidharth Chopra, Carol E. Green, Tiffany R. Keepers, Lynne Gilfillan, Peter B. Madrid, Lalitha V. Iyer, Holli Hutcheson Dilks, Walter H. Moos, Sina Bavari, Ian D. Manger, RaeLyn L. Burke, Ricardo Carrion, Andrey A. Kolokoltsov, Amy C. Shurtleff
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 4, p e60579 (2013)
PLoS ONE, Vol 8, Iss 4, p e60579 (2013)
BACKGROUND: The rapid development of effective medical countermeasures against potential biological threat agents is vital. Repurposing existing drugs that may have unanticipated activities as potential countermeasures is one way to meet this importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0644d30febf2b0ddea2a1cbb37f493fa
https://pubmed.ncbi.nlm.nih.gov/23577127
https://pubmed.ncbi.nlm.nih.gov/23577127