Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ian D Ferguson"'
Publikováno v:
Cell Stress, Vol 6, Iss 11, Pp 89-92 (2022)
The cell surface proteome (“surfaceome”) serves as the interface between diseased cells and their local microenvironment. In cancer, this compartment is critical not only for defining tumor biology but also serves as a rich source of potential th
Externí odkaz:
https://doaj.org/article/039be176bcd64b4aae0c41faad684092
Autor:
Ian D. Ferguson, Bonell Patiño-Escobar, Sami T. Tuomivaara, Yu-Hsiu T. Lin, Matthew A. Nix, Kevin K. Leung, Corynn Kasap, Emilio Ramos, Wilson Nieves Vasquez, Alexis Talbot, Martina Hale, Akul Naik, Audrey Kishishita, Priya Choudhry, Antonia Lopez-Girona, Weili Miao, Sandy W. Wong, Jeffrey L. Wolf, Thomas G. Martin, Nina Shah, Scott Vandenberg, Sonam Prakash, Lenka Besse, Christoph Driessen, Avery D. Posey, R. Dyche Mullins, Justin Eyquem, James A. Wells, Arun P. Wiita
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The myeloma cell surface proteome regulates plasma cell biology and delineates therapy targets. Here, the authors profile the myeloma surfaceome at baseline and in drug resistance, finding the potential target CCR10, and include a streamlined approac
Externí odkaz:
https://doaj.org/article/c60c92825695486592fb827ec64cf75c
Autor:
Hector H. Huang, Ian D. Ferguson, Alexis M. Thornton, Prabhakar Bastola, Christine Lam, Yu-Hsiu T. Lin, Priya Choudhry, Margarette C. Mariano, Makeba D. Marcoulis, Chin Fen Teo, Julia Malato, Paul J. Phojanakong, Thomas G. Martin, Jeffrey L. Wolf, Sandy W. Wong, Nina Shah, Byron Hann, Angela N. Brooks, Arun P. Wiita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The mechanisms of action of proteasome inhibitors (PI) in multiple myeloma (MM) treatment are not fully elucidated. Here, the authors use unbiased phosphoproteomics in PI-treated MM and show increased phosphorylation of splicing-associated proteins,
Externí odkaz:
https://doaj.org/article/9ede6677994c4ad081bb8e902cda0b7a
Autor:
Yu-Hsiu T. Lin, Gregory P. Way, Benjamin G. Barwick, Margarette C. Mariano, Makeba Marcoulis, Ian D. Ferguson, Christoph Driessen, Lawrence H. Boise, Casey S. Greene, Arun P. Wiita
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3214-3227 (2019)
Abstract: A major driver of multiple myeloma (MM) is thought to be aberrant signaling, yet no kinase inhibitors have proven successful in the clinic. Here, we employed an integrated, systems approach combining phosphoproteomic and transcriptome analy
Externí odkaz:
https://doaj.org/article/b53652b0b02e43968b7e68a237b3e8f4
Autor:
Ian D. Ferguson, Patricia Griffin, Joshua J. Michel, Hiroshi Yano, Sarah L. Gaffen, Robert G. Mueller, Jeffrey A. Dvergsten, Jon D. Piganelli, Margalit E. Rosenkranz, Daniel A. Kietz, Abbe N. Vallejo
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
T cells are considered autoimmune effectors in juvenile idiopathic arthritis (JIA), but the antigenic cause of arthritis remains elusive. Since T cells comprise a significant proportion of joint-infiltrating cells, we examined whether the environment
Externí odkaz:
https://doaj.org/article/757c2d5e02994195bbce2ee52debeb3b
Autor:
Christine Lam, Ian D. Ferguson, Margarette C. Mariano, Yu-Hsiu T. Lin, Megan Murnane, Hui Liu, Geoffrey A. Smith, Sandy W. Wong, Jack Taunton, Jun O. Liu, Constantine S. Mitsiades, Byron C. Hann, Blake T. Aftab, Arun P. Wiita
Publikováno v:
Haematologica, Vol 103, Iss 7 (2018)
The myeloma bone marrow microenvironment promotes proliferation of malignant plasma cells and resistance to therapy. Activation of JAK/STAT signaling is thought to be a central component of these microenvironment-induced phenotypes. In a prior drug r
Externí odkaz:
https://doaj.org/article/0de808fc838c456d8a047ff83151b7c6
Autor:
Weili Miao, Douglas F. Porter, Vanessa Lopez-Pajares, Zurab Siprashvili, Robin M. Meyers, Yunhao Bai, Duy T. Nguyen, Lisa A. Ko, Brian J. Zarnegar, Ian D. Ferguson, Matthew M. Mills, Christie E. Jilly-Rehak, Cheng-Guo Wu, Yen-Yu Yang, Jordan M. Meyers, Audrey W. Hong, David L. Reynolds, Muthukumar Ramanathan, Shiying Tao, Sizun Jiang, Ryan A. Flynn, Yinsheng Wang, Garry P. Nolan, Paul A. Khavari
Publikováno v:
Cell. 186(1)
Glucose is a universal bioenergy source; however, its role in controlling protein interactions is unappreciated, as are its actions during differentiation-associated intracellular glucose elevation. Azido-glucose click chemistry identified glucose bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97915faafb36752f79d6715ae2778575
https://pubmed.ncbi.nlm.nih.gov/36608661
https://pubmed.ncbi.nlm.nih.gov/36608661
Autor:
Yen-Yu Yang, Ronald L. Shanderson, Muthukumar Ramanathan, Jordan M. Meyers, Paul A. Khavari, Yinsheng Wang, Catherine A. Blish, David Reynolds, Aimee Beck, Deepti Rao, Yang Zhao, Margaret Guo, Ian D Ferguson, Weili Miao, Laura K. Donohue, Xue Yang
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009412 (2021)
PLoS Pathogens
bioRxiv
PLoS Pathogens
bioRxiv
Viral proteins localize within subcellular compartments to subvert host machinery and promote pathogenesis. To study SARS-CoV-2 biology, we generated an atlas of 2422 human proteins vicinal to 17 SARS-CoV-2 viral proteins using proximity proteomics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effd24503a8fda690940ab94fd8c31b7
https://doi.org/10.1101/2021.02.23.432450
https://doi.org/10.1101/2021.02.23.432450
Publikováno v:
bioRxiv
The Lancet. Infectious Diseases
The Lancet. Infectious Diseases
SARS-CoV2 being highly infectious has been particularly effective in causing widespread infection globally and more variants of SARS-CoV2 are constantly being reported with increased genomic surveillance. In particular, the focus is on mutations of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2b3500bb57f1470f0ad79f5e27d0f0
https://europepmc.org/articles/PMC7924271/
https://europepmc.org/articles/PMC7924271/
Autor:
Ian D. Ferguson, Yu-Hsiu T. Lin, Christine Lam, Hao Shao, Kevin M. Tharp, Martina Hale, Corynn Kasap, Margarette C. Mariano, Audrey Kishishita, Bonell Patiño Escobar, Kamal Mandal, Veronica Steri, Donghui Wang, Paul Phojanakong, Sami T. Tuomivaara, Byron Hann, Christoph Driessen, Brian Van Ness, Jason E. Gestwicki, Arun P. Wiita
Publikováno v:
Cell chemical biology. 29(8)
Proteasome inhibitor (PI) resistance remains a central challenge in multiple myeloma. To identify pathways mediating resistance, we first mapped proteasome-associated genetic co-dependencies. We identified heat shock protein 70 (HSP70) chaperones as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59e3958ef7071082cfd611118aec457
https://pubmed.ncbi.nlm.nih.gov/35853457
https://pubmed.ncbi.nlm.nih.gov/35853457