Amine-linked diglycosides: Synthesis facilitated by the enhanced reactivity of allylic electrophiles, and glycosidase inhibition assays

Autor: Ian Cumpstey, Jens Frigell, Elias Pershagen, Tashfeen Akhtar, Elena Moreno-Clavijo, Inmaculada Robina, Dominic S. Alonzi, Terry D. Butters

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 7, Iss 1, Pp 1115-1123 (2011)

Diglycose derivatives, consisting of two monosaccharides linked at non-anomeric positions by a bridging nitrogen atom, have been synthesised. Conversion of one of the precursor monosaccharide coupling components into an unsaturated derivative enhance

Externí odkaz: https://doaj.org/article/aa6d4c41b8c3436095de710c4f8b67e2

Chemical Modification of Polysaccharides

Autor: Ian Cumpstey

Publikováno v: ISRN Organic Chemistry

This review covers methods for modifying the structures of polysaccharides. The introduction of hydrophobic, acidic, basic, or other functionality into polysaccharide structures can alter the properties of materials based on these substances. The dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1ddfad920962ce9779fc0c10a7b165
https://doi.org/10.1155/2013/417672

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

Autor: Bader A. Salameh, Hans Thalsgaard Schambye, Santanu Mandal, Gunjan Sharma, Ulf J. Nilsson, Alison C. MacKinnon, John Stegmayr, Monique van Scherpenzeel, Amaia Larumbe, P.M. Collins, Vishal Kumar Rajput, Barbro Kahl-Knutsson, Tariq Sethi, Hilde van Hattum, Ian Cumpstey, Roland J. Pieters, Tamara Delaine, Hakon Leffler, Stina Oredsson, Helen Blanchard

Publikováno v: ChemBioChem; 17(18), pp 1759-1770 (2016)
ChemBioChem, 17, 18, pp. 1759-1770
ChemBioChem, 17, 1759-1770
Delaine, T, Collins, P, MacKinnon, A, Sharma, G, Stegmayr, J, Rajput, V K, Mandal, S, Cumpstey, I, Larumbe, A, Salameh, B A, Kahl-Knutsson, B, van Hattum, H, van Scherpenzeel, M, Pieters, R J, Sethi, T, Schambye, H, Oredsson, S, Leffler, H, Blanchard, H & Nilsson, U J 2016, ' Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition ', ChemBioChem . https://doi.org/10.1002/cbic.201600285

Discovery of glycan-competitive galectin-3-binding compounds that attenuate lung fibrosis in a murine model and that block intracellular galectin-3 accumulation at damaged vesicles, hence revealing galectin-3-glycan interactions involved in fibrosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaa90d856d56ee08728755713b58e08
https://pubmed.ncbi.nlm.nih.gov/27356186

Photoinitiated Glycosylation at 350 nm

Autor: David Crich, Ian Cumpstey

Publikováno v: Journal of Carbohydrate Chemistry. 30:469-485

A method for photochemical activation of glycosyl donors is presented. Selenoglycosides were activated by single-electron transfer using a photooxidant, N-methylquinolinium hexafluorophosphate, as photosensitizer and a toluene cosolvent as cosensitiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f323662dccda3722fe2aa6e25ec1dcd2
https://doi.org/10.1080/07328303.2011.601533

Investigation of Coupling Reactions for the Synthesis of Valienamine Pseudodisaccharides

Autor: Ian Cumpstey, K. Eszter Borbas, Clinton Ramstadius

Publikováno v: Synlett. 2011:1701-1704

Amine-linked pseudodisaccharides based on valienamine were synthesised by C-N bond-forming reactions between valienol-derived C-1 electrophiles and carbohydrate nitrogen nucleophiles. Palladium-catalysed coupling with trichloroacetimidate leaving gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d60633b1a20f2209c832df9c8623cf5
https://doi.org/10.1055/s-0030-1260801