Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Ian Clark-Lewis"'
Ethanol exerts its actions in the central and peripheral nervous systems through the direct interactions with several proteins, including ligand-gated ion channels such as the nicotinic acetylcholine receptor (nAChR). The binding interaction between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707d653156e9de85d0c0247fb669a174
Publikováno v:
Biochemistry. 45:7882-7888
Interleukin-8 (IL-8), a member of the chemokine superfamily, exists as both monomers and dimers, and mediates its function by binding to neutrophil CXCR1 and CXCR2 receptors that belong to the G protein-coupled receptor class. It is now well establis
Autor:
Anna E. Szafranska, Christopher J. Arthur, Matthew P. Crump, Thomas J. Simpson, Steven G. Burston, Philip Owen, Simon Evans, John Crosby, Ian Clark-Lewis, Stuart C. Findlow
Publikováno v:
Biochemistry. 44:15414-15421
During polyketide biosynthesis, malonyl groups are transferred to the acyl carrier protein (ACP) component of the polyketide synthase (PKS), and it has been shown that a number of type II polyketide ACPs undergo rapid self-acylation from malonyl-CoA
Autor:
Barrett J. Rollins, Themis R. Kyriakides, Annabel T. Tsai, Grant E. Keeney, Cecilia M. Giachelli, Matt J. Foster, Paul Bornstein, Ian Clark-Lewis
Publikováno v:
The American Journal of Pathology. 165:2157-2166
The foreign body reaction (FBR) develops in response to the implantation of almost all biomaterials and can be detrimental to their function. The formation of foreign body giant cells (FBGC), which damage the surface of biomaterials, is considered a
Publikováno v:
Journal of Biological Chemistry. 279:40276-40282
Chemokines constitute a group of over 40 secreted peptides that are important for the control of leukocyte migration both during homeostasis and inflammation. Recent studies have implicated the ligands CCL19 and CCL21 and their receptor, CCR7, in the
Autor:
Janet Holden, G. Angus McQuibban, Christopher Power, Georgina S. Butler, Christopher M. Overall, James B. Johnston, Kunyan Zhang, Ian Clark-Lewis, Claudia Silva
Publikováno v:
Nature Neuroscience. 6:1064-1071
The mechanisms of neurodegeneration that result in human immunodeficiency virus (HIV) type 1 dementia have not yet been identified. Here, we report that HIV-infected macrophages secrete the zymogen matrix metalloproteinase-2 (MMP-2), which is activat
Publikováno v:
The Journal of Immunology. 170:6298-6306
Chemokines are a family of cytokines that exhibit selective chemoattractant properties for target leukocytes and play a significant role in leukocyte migration. In this study, we have investigated the role of the C-C chemokine, macrophage inflammator
Publikováno v:
The American Journal of Pathology. 162:1183-1190
Cathepsin D (Cath-D) expression in human primary breast cancer has been associated with a poor prognosis. In search of a better understanding of the Cath-D substrates possibly involved in cancer invasiveness and metastasis, we investigated the potent
Autor:
Peter Østrup Jensen, Claus Moser, Thue W. Schwartz, Jan Gerstoft, Hans R. Lüttichau, Ian Clark-Lewis
Publikováno v:
Journal of Biological Chemistry. 278:10928-10933
The chemokine-like, secreted protein product of the U83 gene from human herpesvirus 6, here named vCCL4, was chemically synthesized to be characterized in a complete library of the 18 known human chemokine receptors expressed individually in stably t
Publikováno v:
Journal of Molecular Biology. 327:329-334
Determining the critical structural features a ligand must possess in order to bind to its receptor is of key importance to the understanding of vital biological processes and to the rational design of small molecule therapeutics to modulate receptor