Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Ian Chute"'
Autor:
Annie Barsalou, Normand Beaulieu, Marja Dubay, Naomy Bernstein, Jeff Gillespie, Marie-France Robert, Jubrail Rahil, Isabelle Dupont, Ian Chute, Sylvain Lefebvre, Marie-Claude Granger, Hannah Nguyen, Oscar Mario Saavedra, James Wang, Jeffrey M. Besterman, Serge Gravel, Amal Wahhab, Lijie Zhan, Arkadii Vaisburg, Roussen Pascal, Carole Beaulieu, Zhiyun Jin, Franck Raeppel, Robert Deziel, David B. Llewellyn, A. Robert MacLeod, Stephen William Claridge
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2793-2798
A series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases is described. The compounds demonstrated potency with IC50 values in the low nanomolar range in vitro while the lead compound also showed in vivo activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c793d69f791b3bd653b579bbb81a8c8
https://doi.org/10.1016/j.bmcl.2008.04.009
https://doi.org/10.1016/j.bmcl.2008.04.009
Autor:
Ian Chute, Normand Beaulieu, Marie-France Robert, A. Robert MacLeod, Steves Morin, Hannah Nguyen
Publikováno v:
Journal of Biological Chemistry. 277:28176-28181
Abnormal methylation and associated silencing of tumor suppressor genes is a common feature of many types of cancers. The observation of persistent methylation in human cancer cells lacking the maintenance methyltransferase DNMT1 suggests the involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62ed8be3bcf70661d1d48ecd900ee2c
https://doi.org/10.1074/jbc.m204734200
https://doi.org/10.1074/jbc.m204734200
Autor:
Carole Beaulieu, Marja Dubay, Jeffrey M. Besterman, Stephane Raeppel, Jubrail Rahil, Nancy Z. Zhou, Ian Chute, Arkadii Vaisburg, Lijie Zhan, Isabelle Dupont, Hannah Nguyen, Ljubomir Isakovic, James Wang, Robert Deziel, Stephen William Claridge, Frédéric Gaudette, A. Robert MacLeod, Normand Beaulieu, Hélène Ste-Croix, Marie-France Robert, Sylvain Lefebvre, Oscar Mario Saavedra, Michael Mannion, Franck Raeppel
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(23)
A series of N-(4-(6,7-disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting c-Met and VEGFR2 tyrosine kinases was designed and synthesized. The compounds were potent against these two enzymes with IC(50)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9020f89c6b464506c2acebb912014e
https://pubmed.ncbi.nlm.nih.gov/19854051
https://pubmed.ncbi.nlm.nih.gov/19854051