Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Ian Cheong"'
Autor:
Rongji Sum, Sylvester Jian Ming Lim, Ajitha Sundaresan, Sudipta Samanta, Muthukaruppan Swaminathan, Wayne Low, Madhumitha Ayyappan, Ting Wei Lim, Marvin Dragon Choo, Gabriel Junming Huang, Ian Cheong
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Clostridium septicum infections are highly predictive of certain malignancies in human patients. To initiate infections, C. septicum spores must first germinate and regain vegetative growth. Yet, what triggers the germination of C. septicum
Externí odkaz:
https://doaj.org/article/05cde37edf0640dba55e059814ad3d24
Autor:
Ajitha Sundaresan, Mai Le Ngoc, Marvell Ung Wew, Varsha Ramkumar, Prahlad Raninga, Rongji Sum, Ian Cheong
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
A screen for germination of Clostridium novyi-NT spores reveals that germinant sensing of this tumor-destructive anaerobic bacterium is stereoflexible for valine and its analogs and identifies co-germinants to improve germination efficacy in tumors.
Externí odkaz:
https://doaj.org/article/f3bf4aa474d94ad49d90e51b24dca205
Autor:
Pratibha Bhai, Benjamin Chin-Yee, Victor Pope, Ian Cheong, Maxim Matyashin, Michael A. Levy, Aidin Foroutan, Alan Stuart, Cyrus C. Hsia, Hanxin Lin, Bekim Sadikovic, Ian Chin-Yee
Publikováno v:
Current Oncology, Vol 29, Iss 10, Pp 7209-7217 (2022)
Background: Since the identification of JAK2 V617F and exon 12 mutations as driver mutations in polycythemia vera (PV) in 2005, molecular testing of these mutations for patients with erythrocytosis has become a routine clinical practice. However, the
Externí odkaz:
https://doaj.org/article/3f897fc6e5724f84ae1912b24b087ec4
Autor:
Veronica Rendo, Ivaylo Stoimenov, André Mateus, Elin Sjöberg, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Adrian Ng, Casey OʼBrien, Marios Giannakis, Per Artursson, Peter Nygren, Ian Cheong, Tobias Sjöblom
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Allelic losses occurring in cancer cells have been suggested as potential targets for therapy. Here, the authors show how recurring loss of heterozygosity of a drug metabolic gene in colorectal cancers can be exploited using a low molecular weight co
Externí odkaz:
https://doaj.org/article/f0524ece03f240dd980cb46a0462a392
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232755 (2020)
The quality control of intracellular proteins is achieved by degrading misfolded proteins which cannot be refolded by molecular chaperones. In eukaryotes, such degradation is handled primarily by the ubiquitin-proteasome system. However, it remained
Externí odkaz:
https://doaj.org/article/4a865fd316094096851c71c262bae1d3
Autor:
Wouter J. C. Feitz, Nicole C. A. J. van de Kar, Ian Cheong, Thea J. A. M. van der Velden, Carolina G. Ortiz-Sandoval, Dorothea Orth-Höller, Lambert P. J. W. van den Heuvel, Christoph Licht
Publikováno v:
Toxins, Vol 12, Iss 8, p 483 (2020)
Hemolytic uremic syndrome (HUS) is a rare disease primarily characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Endothelial damage is the hallmark of the pathogenesis of HUS with an infection with the Shiga toxin (Stx) produ
Externí odkaz:
https://doaj.org/article/5eb0a7aba7d740c988b3f38747293aad
Autor:
Luis A Diaz, Catherine A Foss, Katherine Thornton, Sridhar Nimmagadda, Christopher J Endres, Ovsev Uzuner, Thorsten M Seyler, Slif D Ulrich, Janet Conway, Chetan Bettegowda, Nishant Agrawal, Ian Cheong, Xiaosong Zhang, Paul W Ladenson, Barry N Vogelstein, Michael A Mont, Shibin Zhou, Kenneth W Kinzler, Bert Vogelstein, Martin G Pomper
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e1007 (2007)
Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinas
Externí odkaz:
https://doaj.org/article/291fccec121f4a20bd86b816d20c8dfd
Autor:
Ian Cheong
Publikováno v:
Journal of Innovation in Health Informatics, Vol 5, Iss 1, Pp 15-17 (1996)
Privacy and security of personal health information continue to generate much discussion and debate. Significant international initiatives appear to be little known. "Privacy" and "security" in terms of information are poorly understood terms. The ke
Externí odkaz:
https://doaj.org/article/f11865857c33444ea8a5df3301ff07a1
Autor:
Benjamin, Chin-Yee, Maxim, Matyashin, Ian, Cheong, Pratibha, Bhai, Alejandro, Lazo-Langner, Ala, Almanaseer, Eri, Kawata, Michael A, Levy, Alan, Stuart, Hanxin, Lin, Ian, Chin-Yee, Bekim, Sadikovic, Cyrus, Hsia
Publikováno v:
CMAJ Open. 10:E988-E992
Molecular testing foriJAK2/imutations is part of the standard diagnostic workup for patients with suspected polycythemia vera. We sought to characterize evolving practice patterns in the investigation of erythrocytosis and the prevalence of secondary
Autor:
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Publikováno v:
The American Journal of Pathology. 192:1295-1304