Esrrb Complementation Rescues Development of Nanog-Null Germ Cells

Autor: Man Zhang, Harry G. Leitch, Walfred W.C. Tang, Nicola Festuccia, Elisa Hall-Ponsele, Jennifer Nichols, M. Azim Surani, Austin Smith, Ian Chambers

Publikováno v: Cell Reports, Vol 22, Iss 2, Pp 332-339 (2018)

Summary: The transcription factors (TFs) Nanog and Esrrb play important roles in embryonic stem cells (ESCs) and during primordial germ-cell (PGC) development. Esrrb is a positively regulated direct target of NANOG in ESCs that can substitute qualita

Externí odkaz: https://doaj.org/article/4af805fa2a50420993ccde52a768d491

Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs

Autor: Damir Jacob Illich, Miao Zhang, Andrei Ursu, Rodrigo Osorno, Kee-Pyo Kim, Juyong Yoon, Marcos J. Araúzo-Bravo, Guangming Wu, Daniel Esch, Davood Sabour, Douglas Colby, Kathrin S. Grassme, Jiayu Chen, Boris Greber, Susanne Höing, Wiebke Herzog, Slava Ziegler, Ian Chambers, Shaorong Gao, Herbert Waldmann, Hans R. Schöler

Publikováno v: Cell Reports, Vol 15, Iss 4, Pp 787-800 (2016)

It has previously been reported that mouse epiblast stem cell (EpiSC) lines comprise heterogeneous cell populations that are functionally equivalent to cells of either early- or late-stage postimplantation development. So far, the establishment of th

Externí odkaz: https://doaj.org/article/bcd0b9b6536d410aacc68d28af505701

Distinct SoxB1 networks are required for naïve and primed pluripotency

Autor: Andrea Corsinotti, Frederick CK Wong, Tülin Tatar, Iwona Szczerbinska, Florian Halbritter, Douglas Colby, Sabine Gogolok, Raphaël Pantier, Kirsten Liggat, Elham S Mirfazeli, Elisa Hall-Ponsele, Nicholas P Mullin, Valerie Wilson, Ian Chambers

Publikováno v: eLife, Vol 6 (2017)

Deletion of Sox2 from mouse embryonic stem cells (ESCs) causes trophectodermal differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, SOX1 or SOX3, the roles of SOXB1 proteins in epiblast stem cell (EpiSC)

Externí odkaz: https://doaj.org/article/383310e3d27d44c8aad4b1b095ff1014

A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis.

Autor: Ewart W Kuijk, Jeffrey de Gier, Susana M Chuva de Sousa Lopes, Ian Chambers, Ans M M van Pelt, Ben Colenbrander, Bernard A J Roelen

Publikováno v: PLoS ONE, Vol 5, Iss 6, p e10987 (2010)

NANOG is a key player in pluripotency and its expression is restricted to pluripotent cells of the inner cell mass, the epiblast and to primordial germ cells. Spermatogenesis is closely associated with pluripotency, because through this process highl

Externí odkaz: https://doaj.org/article/bf2b995601c643e592957276c173c077

Differential repression of Otx2 underlies the capacity of NANOG and ESRRB to induce germline entry

Autor: Matúš Vojtek, Jingchao Zhang, Juanjuan Sun, Man Zhang, Ian Chambers

Publikováno v: Stem Cell Reports
Vojtek, M, Zhang, J, Sun, J, Zhang, M & Chambers, I 2022, ' Differential repression of Otx2 underlies the capacity of NANOG and ESRRB to induce germline entry ', Stem Cell Reports, vol. 17, no. 1, pp. 35-42 . https://doi.org/10.1016/j.stemcr.2021.11.013

Summary Primordial germ cells (PGCs) arise from cells of the post-implantation epiblast in response to cytokine signaling. PGC development can be recapitulated in vitro by differentiating epiblast-like cells (EpiLCs) into PGC-like cells (PGCLCs) thro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dfe94fe2d497ff95f01bda72644bac6
https://doi.org/10.1016/j.stemcr.2021.11.013