Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ian C.-K. Lau"'
Autor:
Ian C-K Lau, Joel H. Z. Lee, John B. Bruning, James J. De Voss, Rebecca R. Chao, Stephen Bell, T. Coleman, Stella A. Child, Luke R. Churchman
Publikováno v:
Chemistry – A European Journal. 27:14765-14777
The serine 244 to aspartate (S244D) variant of the cytochrome P450 enzyme CYP199A4 was used to expand its substrate range beyond benzoic acids. Substrates, in which the carboxylate group of the benzoic acid moiety is replaced were oxidised with high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba6e7e0924857eb7beb371ff7cfb43b
https://doi.org/10.1002/chem.202102757
https://doi.org/10.1002/chem.202102757
Publikováno v:
Archives of Biochemistry and Biophysics. 669:11-21
Frankia bacteria are nitrogen fixing species from the Actinobacterium phylum which live on the root nodules of plants. They have been hypothesised to have significant potential for natural product biosynthesis. The cytochrome P450 monooxygenase compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3d9a594f83d36cd3fe166caec8810a
https://doi.org/10.1016/j.abb.2019.05.007
https://doi.org/10.1016/j.abb.2019.05.007
Publikováno v:
ChemCatChem. 9:2512-2522
Cytochrome P450 CYP102A1 (P450 Bm3) variants were used to investigate the products arising from the P450 catalysed oxidation of a range of disubstituted benzenes. The variants used all generated increased levels of metabolites compared to the wild-ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::911d509ed3d62709ad16863c849aace4
https://doi.org/10.1002/cctc.201700116
https://doi.org/10.1002/cctc.201700116
Publikováno v:
ChemCatChem. 8:3626-3635
The bacterial CYP199A4 enzyme is able to efficiently oxidise a narrow range of aromatic acids including 4-methoxybenzoic acid. A serine-244 to aspartate variant was identified with enhanced activity for a wide range of para-methoxy substituted benzen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6b13a998ff9015903bc8024fdf01b63
https://doi.org/10.1002/cctc.201600951
https://doi.org/10.1002/cctc.201600951