Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ian C. Ragan"'
Autor:
Leslie J. Street, George R. Marshall, Bindi Sohal, Ruth M. McKernan, Andrew Mitchinson, Susan M. Cook, Andrew Pike, José L. Castro, Robert W. Carling, Timothy Harrison, Ian C. Ragan, Sally Ann Thompson, John R. Atack, K Quirk, Andrew Madin, Kevin W. Moore, Michael G. N. Russell, Alec Guiblin, Keith A. Wafford, Gerard R. Dawson, Pushpinder Ferris
Publikováno v:
Journal of Medicinal Chemistry. 48:7089-7092
There is increasing evidence that compounds with selectivity for gamma-aminobutyric acid(A) (GABA(A)) alpha2- and/or alpha3-subtypes may retain the desirable anxiolytic activity of nonselective benzodiazepines but possess an improved side effect prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5669d56878a0d056aa7267380a12e4df
https://doi.org/10.1021/jm058034a
https://doi.org/10.1021/jm058034a
Autor:
Robert W, Carling, Andrew, Madin, Alec, Guiblin, Michael G N, Russell, Kevin W, Moore, Andrew, Mitchinson, Bindi, Sohal, Andrew, Pike, Susan M, Cook, Ian C, Ragan, Ruth M, McKernan, Kathleen, Quirk, Pushpinder, Ferris, George, Marshall, Sally Ann, Thompson, Keith A, Wafford, Gerard R, Dawson, John R, Atack, Timothy, Harrison, José L, Castro, Leslie J, Street
Publikováno v:
Journal of medicinal chemistry. 48(23)
There is increasing evidence that compounds with selectivity for gamma-aminobutyric acid(A) (GABA(A)) alpha2- and/or alpha3-subtypes may retain the desirable anxiolytic activity of nonselective benzodiazepines but possess an improved side effect prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a11d1ee79c8642933071ece34a27f2e3
https://pubmed.ncbi.nlm.nih.gov/16279764
https://pubmed.ncbi.nlm.nih.gov/16279764
Autor:
Linda J. Bristow, Susan M. Cook, John R. Atack, Bindi Sohal, Robert W. Carling, Ruth M. McKernan, Ian C. Ragan, David Melillo, Keith A. Wafford, Fran Bromidge, Paul J. Whiting, Julie Kerby, Les Street, José L. Castro, Andrew Pike, Cyrille Sur, Gerard R. Dawson, Spencer J. Tye
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 316(1)
7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) is a triazolopyridazine that binds with equivalent high (subnanomolar) affinity to the benzodiazepine binding site of recombina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fff9c47b2ff30278e4fdaea2707580b
https://pubmed.ncbi.nlm.nih.gov/16183706
https://pubmed.ncbi.nlm.nih.gov/16183706
Autor:
Ian Collins, Michael Rowley, Alan E. Fletcher, William B Davey, Ann L Scott, Rosemarie Marwood, Shil Patel, F. Emms, Paul D. Leeson, Theodore P. Broten, Ian C. Ragan, Smita Patel
Publikováno v:
Bioorganicmedicinal chemistry. 6(6)
3-(4-Piperidinyl)-5-arylpyrazoles, such as 1, were selective for the cloned human dopamine D4 receptor (hD4), but also showed affinity at voltage sensitive calcium, sodium and potassium ion channels. A combination of substituent changes to reduce the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f7c49406a6edd03c6b3f84a8b9eaf6
https://pubmed.ncbi.nlm.nih.gov/9681140
https://pubmed.ncbi.nlm.nih.gov/9681140
Publikováno v:
European journal of biochemistry. 201(3)
A human-hepatoma cDNA lambda gt11 expression library was probed with an antibody to holoenzyme complex I (NADH-CoQ reductase) of the respiratory chain. One of the 30 antibody positive clones was purified to homogeneity, amplified by the polymerase ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49d265040586064f41e21ef09845756
https://pubmed.ncbi.nlm.nih.gov/1935949
https://pubmed.ncbi.nlm.nih.gov/1935949