Výsledky vyhledávání - "Ian C. Bathurst"

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes

Autor: Ian C. Bathurst, David J. Fischer, L. David Tomei, Károly Liliom, Gabor Tigyi, Zhong Guo, Michael C. Kiefer

Publikováno v: Proceedings of the National Academy of Sciences. 93:14367-14372

Lysophosphatidic acid (1-acyl-2-lyso- sn -glycero-3-phosphate, LPA) is a multifunctional lipid mediator found in a variety of organisms that span the phylogenetic tree from humans to plants. Although its physiological function is not clearly understo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fddf84ce595bc977f775a2457f85fd
https://doi.org/10.1073/pnas.93.25.14367

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Saccharomyces cerevisiae recombinant Pfs25 adsorbed to alum elicits antibodies that block transmission of Plasmodium falciparum

Autor: T Lensen, Ian C. Bathurst, David B. Keister, Philip J. Barr, David C. Kaslow, T. Ponnudurai

Publikováno v: Infection and Immunity. 62:5576-5580

Antibodies to Pfs25, a cysteine-rich 25-kDa protein present on the surface of Plasmodium falciparum zygotes, can completely block the transmission of malaria parasites when mixed with infectious blood and fed to mosquitoes through a membrane feeding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbafabbb415f37ed0ded528fbad56ce
https://doi.org/10.1128/iai.62.12.5576-5580.1994

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Life-spans of human T-cell responses to determinants from the circumsporozoite proteins of Plasmodium falciparum and Plasmodium vivax

Autor: L Tungviboonchai, P. Barr, Yinka Zevering, Michael F. Good, J Ruengpipattanapan, K Rungruengthanakit, Ian C. Bathurst, C Khamboonruang

Publikováno v: Proceedings of the National Academy of Sciences. 91:6118-6122

The longevity of specific human memory T-cell responses is largely unknown. However, a knowledge of the duration of memory is important for understanding immunity to an organism and for planning vaccine intervention. To address this, we have examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ac4287946f0f218b4b079dbfa1f509
https://doi.org/10.1073/pnas.91.13.6118

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An experimental vaccine cocktail for Plasmodium falciparum malaria

Autor: Philip J. Barr, Benjamin K. Hahm, Isabella A. Quakyi, Wasim A. Siddiqui, Joe Kansopon, Ian C. Bathurst, Pascal Millet, Sandra P. Chang, Helen L. Gibson, Joseph Inselburg, David C. Kaslow, Kim M. Green, George Hui

Publikováno v: Vaccine. 11:449-456

Surface proteins from several different life-cycle stages of the malaria parasite Plasmodium falciparum were expressed at high levels in the yeast Saccharomyces cerevisiae. Purified proteins, both individually and in cocktails, were used to immunize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc3fce07d5885db5911ac1580fcb61e
https://doi.org/10.1016/0264-410x(93)90287-8

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Pyridoxal-5′-Phosphate Inhibits the Polymerase Activity of a Recombinant RNase H-Deficient Mutant of HIV-1 Reverse Transcriptase

Autor: Philip J. Barr, Laura K. Moen, Ian C. Bathurst

Publikováno v: AIDS Research and Human Retroviruses. 8:597-604

We have investigated the ability of pyridoxal-5'-phosphate to inhibit a recombinant deletion mutant of human immunodeficiency virus type 1(HIV-1) reverse transcriptase (RT) which is missing the last 23 amino acids of the C-terminus. This mutant rever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d75c945611e9b5cc89995fc66ece0c
https://doi.org/10.1089/aid.1992.8.597

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Inhibitory activity against sporozoites induced by antibodies directed against nonrepetitive regions of the circumsporozoite protein ofPlasmodium vivax

Autor: Gary H. Campbell, J. Roger Broderson, Carlo Chizzolini, Robert A. Wirtz, William E. Collins, Ian C. Bathurst, Pascal Millet

Publikováno v: European Journal of Immunology. 22:519-524

In previous studies, Saimiri sciureus boliviensis monkeys have been immunized with four recombinant proteins reproducing part of the circumsporozoite (CS) protein of Plasmodium vivax sporozoites (NS1(81) V20, rPvCS-1, rPvCS-2, rPv-CS-3), or with irra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cd2d20e358383ca4f9a2334665e1c1
https://doi.org/10.1002/eji.1830220234

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Plasmodium vivax Sporozoite Antibodies in Individuals Exposed during a Single Malaria Outbreak in a Non-Endemic Area

Autor: Ian C. Bathurst, Antoniana U. Krettli, Cor C. J. Fontes

Publikováno v: The American Journal of Tropical Medicine and Hygiene. 44:28-33

We studied seroreactivity against Plasmodium vivax antigens in 62 individuals living in a small community near Mantena, Minas Gerais, Brazil, an area outside the endemic malaria zone Brazil. Eight months earlier, there had been transmission of P. viv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86c8b67de6d44f8ba7b1cf0201c70b7
https://doi.org/10.4269/ajtmh.1991.44.28

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Stabilization and activation of recombinant human immunodeficiency virus-1 reverse transcriptase-P66

Autor: Qi-Feng Ma, Gerald L. Rowley, Philip J. Barr, George L. Kenyon, Ian C. Bathurst

Publikováno v: Biochemical and Biophysical Research Communications. 167:673-679

Human immunodeficiency virus-1 reverse transcriptase-p66 is surprisingly unstable at 4 degrees C in a typical reverse transcriptase buffer that provides complete stability when enzyme is frozen at -70 degrees C. Incorporation of (rA)n(dT)12-18 templa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e3487a400718b67866732c6d783be8
https://doi.org/10.1016/0006-291x(90)92078-e

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