Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ian C. Gray"'
Chromosome band 10q24 is rich in genes involved in development, tumorigenesis, neurological disorders, hormone metabolism, and environmentally induced disease susceptibility. We have constructed an STS-based integrated physical and genetic map of 10q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8269dea017c47de4cc721a0ad7598e
https://ora.ox.ac.uk/objects/uuid:2ca77d35-559a-463d-94d6-2752cf4069ec
https://ora.ox.ac.uk/objects/uuid:2ca77d35-559a-463d-94d6-2752cf4069ec
Autor:
David John Miller, John S. Mills, Diana Kuehn, Matthias W. Büttner, Bin Zhu, L. H. Tam, Philip Avlar BioVentures Mitchell, David Tebbe, Christian Burschka, Helen Rapley, Ian C. Gray, Parameswary A. Muniandy, Reinhold Tacke, Matthew J. Barnes, Jürgen O. Daiss, Alan G. Hendrick, Julie B. H. Warneck, Richard Conroy, Graham A. Showell, John Gary Montana
Publikováno v:
ChemMedChem. 6:2070-2080
AG-045572 (CMPD1, 1 a) is a nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist that has been investigated for the treatment of sex hormone-related diseases. In the context of systematic studies on sila-substituted drugs, the silicon analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0906f5604ca83099549d80545ab529
https://doi.org/10.1002/cmdc.201100318
https://doi.org/10.1002/cmdc.201100318
Publikováno v:
Comparative and Functional Genomics, Vol 6, Iss 5-6, Pp 268-276 (2006)
Comparative and Functional Genomics
Comparative and Functional Genomics, Vol 6, Iss 5-6, Pp 268-276 (2005)
Comparative and Functional Genomics
Comparative and Functional Genomics, Vol 6, Iss 5-6, Pp 268-276 (2005)
The aryl hydrocarbon receptor nuclear translocator (ARNT) and cathepsin K (CTSK) genes lie in a tandem head-to-tail arrangement on human chromosome 1. The two genes are in extremely close proximity; the usualCTSKtranscription start site is less than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75926fd509828a0dd373b65fbbf9ce10
https://doaj.org/article/b550f21e481d4750ac3c1a222dd74072
https://doaj.org/article/b550f21e481d4750ac3c1a222dd74072
Autor:
David Edwards, Lucie Vizor, Shelly Fuller, Emma Horner, Saffron Brady, Nicholas J. Parkinson, David I. Campbell, Emma L. Coghill, Richard McKeone, Zuzanna Lalanne, Steve D.M. Brown, Roger D. Cox, Pete Glenister, Ann F. C. Roberts, Susan Rodger, David A. Keays, Andy Greenfield, Nigel K. Spurr, Jessica Weedon, Alison Hugill, Mohamed M. Quwailid, Sara Wells, Ian C. Gray, Paul Woodman, Samuel G. Cox, John Willan, Jackie Hunter, Hamish McMath, Neil Dear, Joanne Carey
Publikováno v:
Mammalian Genome. 15:585-591
N-ethyl-N-nitrosourea (ENU) introduces mutations throughout the mouse genome at relatively high efficiency. Successful high-throughput phenotype screens have been reported and alternative screens using sequence-based approaches have been proposed. Fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b742dee89b0077868053fb0b867080
https://doi.org/10.1007/s00335-004-2379-z
https://doi.org/10.1007/s00335-004-2379-z
Autor:
Lesley J. Rooke, John A. Curtin, Nigel K. Spurr, Ian C. Gray, Jo Peters, Ian D. Latham, JE Martin, Elizabeth M. C. Fisher, Lucie Vizor, Sohaila Rastan, Steve D.M. Brown, Derek C. Rogers, Vicky Tsipouri, A. Jackie Hunter, Claire A. Parsons, Colin M. Clapham, P Nolan
Publikováno v:
Comparative and Functional Genomics, Vol 5, Iss 2, Pp 123-127 (2004)
Comparative and Functional Genomics
Comparative and Functional Genomics
Three mutant mice with pigmentation phenotypes were recovered from a genomewide random mouse chemical mutagenesis study. White toes (Whto; MGI:1861986), Belly spot and white toes (Bswt; MGI:2152776) and Dark footpads 2 (Dfp2; MGI:1861991) were identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4855d7b9e8a215f46544578225b122d
https://doaj.org/article/3cb652a5fa51480fb8aa6345a8775d99
https://doaj.org/article/3cb652a5fa51480fb8aa6345a8775d99
Autor:
Ruth M. Arkell, Patrick M. Nolan, Andrew J. Copp, Philip Stanier, Steve D.M. Brown, Ian C. Gray, Karen P. Steel, Deborah J. Henderson, Jennifer N. Murdoch, Nigel K. Spurr, Bruce Cattanach, Vicky Tsipouri, Elizabeth M. C. Fisher, Elizabeth Quint, John A. Curtin
Publikováno v:
Current Biology. 13(13):1129-1133
We identified two novel mouse mutants with abnormal head-shaking behavior and neural tube defects during the course of independent ENU mutagenesis experiments. The heterozygous and homozygous mutants exhibit defects in the orientation of sensory hair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad768889430a65c3e4481ea049aa2443
Autor:
Ian C. Gray, Nigel K. Spurr, A J Hunter, Patrick M. Nolan, Brown Sdm., E L Jones, Alexander Jeans, Anna Katharina Simon, Peter L. Oliver, Pete Glenister, Adrian M. Isaacs, Kay E. Davies, A Potter, B H Hovik, Lucie Vizor
Publikováno v:
The Journal of Neuroscience. 23:1631-1637
The robotic mouse is an autosomal dominant mutant that arose from a large-scale chemical mutagenesis program. It has a jerky, ataxic gait and develops adult-onset Purkinje cell loss in the cerebellum in a striking region-specific pattern, as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a866aea54e0f9ab6dd06a2acd2b6134e
https://doi.org/10.1523/jneurosci.23-05-01631.2003
https://doi.org/10.1523/jneurosci.23-05-01631.2003
Publikováno v:
Human Molecular Genetics. 9:2403-2408
The development of detailed single nucleotide polymorphism (SNP) maps of the human genome coupled with high-throughput genotyping technologies may allow us to unravel complex genetic traits, such as multifactorial disease or drug response, over the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cdcad1c72075986e885fcb93d1e726
https://doi.org/10.1093/hmg/9.16.2403
https://doi.org/10.1093/hmg/9.16.2403
Autor:
Philomena Mburu, Joanne E. Martin, Simon Greenaway, Josephine Peters, Mark A. Strivens, Ian C. Gray, P. Roby, Jean-Louis Guénet, Patrick M. Nolan, Carole D. Nickols, Stéphanie Voegeling, Xue Zhong Liu, R Selley, Adrian M. Isaacs, Stefan L. McCormack, Elizabeth M. C. Fisher, C Thornton, M Browne, Alexandra Erven, Ruth M. Arkell, Tertius Hough, Zuzanna Tymowska-Lalanne, Jackie Hunter, Karen P. Steel, Peter H. Glenister, Kay E. Davies, Rachel E. Hardisty, D Brooker, R Sadri, Nigel K. Spurr, E Whitehill, Lucie Vizor, J A Stevenson, K Pickford, Christine A. Wells, Amy E. Kiernan, M Hewitt, Steve D.M. Brown, Sohaila Rastan, Derek C. Rogers, Caroline Thaung, Jim J. Hagan, R Washbourne, M Nasse
Publikováno v:
Nature Genetics. 25:440-443
As the human genome project approaches completion, the challenge for mammalian geneticists is to develop approaches for the systematic determination of mammalian gene function. Mouse mutagenesis will be a key element of studies of gene function. Phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d69b10742c4b2938bb2e4430adf5d1
https://doi.org/10.1038/78140
https://doi.org/10.1038/78140
Publikováno v:
Cancer Genetics and Cytogenetics. 102:6-11
Rearrangement of distal 10q is a common feature of many tumor types and tumor-derived cell lines. More specifically, loss of 10q23–25 has been demonstrated in a large proportion of prostate tumors, indicative of the presence of a tumor suppressor g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7f8b7cafa73a6e9fc1d6c80beddda6
https://doi.org/10.1016/s0165-4608(97)00250-1
https://doi.org/10.1016/s0165-4608(97)00250-1