Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Ian C Schoenhofen"'
Autor:
Sudeshna Saha, Alison Coady, Aniruddha Sasmal, Kunio Kawanishi, Biswa Choudhury, Hai Yu, Ricardo U. Sorensen, Jaime Inostroza, Ian C. Schoenhofen, Xi Chen, Anja Münster-Kühnel, Chihiro Sato, Ken Kitajima, Sanjay Ram, Victor Nizet, Ajit Varki
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
All cells in vertebrates are coated with a dense array of glycans often capped with sugars called sialic acids. Sialic acids have many functions, including serving as a signal for recognition of “self” cells by the immune system, thereby guiding
Externí odkaz:
https://doaj.org/article/55c19541bb674c079290b532f74dd4fb
Autor:
Lingquan Deng, Theresa Lindhout-Djukic, Melissa J. Schur, Lisa A. Lewis, Ajit Varki, Sunita Gulati, Sanjay Ram, Corinna S. Landig, Sudeshna Saha, Ian C. Schoenhofen, Bo Zheng
Publikováno v:
The Journal of Immunology. 204:3283-3295
Neisseria gonorrhoeae deploys a unique immune evasion strategy wherein the lacto-N-neotetraose termini of lipooligosaccharide (LOS) are “capped” by a surface LOS sialyltransferase (Lst), using extracellular host-derived CMP-sialic acid (CMP-Neu5A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b60cae5627fc81ae4c669390a72415
https://doi.org/10.4049/jimmunol.1901398
https://doi.org/10.4049/jimmunol.1901398
Autor:
Sunita Gulati, Ian C Schoenhofen, Dennis M Whitfield, Andrew D Cox, Jianjun Li, Frank St Michael, Evgeny V Vinogradov, Jacek Stupak, Bo Zheng, Makoto Ohnishi, Magnus Unemo, Lisa A Lewis, Rachel E Taylor, Corinna S Landig, Sandra Diaz, George W Reed, Ajit Varki, Peter A Rice, Sanjay Ram
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005290 (2015)
Neisseria gonorrhoeae deploys a novel immune evasion strategy wherein the lacto-N-neotetraose (LNnT) structure of lipooligosaccharide (LOS) is capped by the bacterial sialyltransferase, using host cytidine-5'-monophosphate (CMP)-activated forms of th
Externí odkaz:
https://doaj.org/article/89c70c9cf5024b6cb742598babff7c2c
Autor:
Kunio Kawanishi, Shoib S. Siddiqui, Sudeshna Saha, Ken Kitajima, Xi Chen, Kumar Sharma, Ian C. Schoenhofen, Biswa Choudhury, Aniruddha Sasmal, Ajit Varki, Anja K. Münster-Kühnel, Sandra Diaz, Michael Vaill, Chihiro Sato, Hudson H. Freeze
Publikováno v:
J Clin Invest
The Journal of clinical investigation, vol 131, iss 5
The Journal of clinical investigation, vol 131, iss 5
Human metabolic incorporation of nonhuman sialic acid (Sia) N-glycolylneuraminic acid into endogenous glycans generates inflammation via preexisting antibodies, which likely contributes to red meat–induced atherosclerosis acceleration. Exploring wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74987f63518d3cdafbae030fc3e1de45
https://europepmc.org/articles/PMC7919724/
https://europepmc.org/articles/PMC7919724/
Autor:
Lisa A. Lewis, Ajit Varki, Peter A. Rice, Ian C. Schoenhofen, Iesha Y Moustafa, Sunita Gulati, Sanjay Ram, Theresa Lindhout-Djukic, Bo Zheng, Sudeshna Saha, Nancy A. Nowak
Publikováno v:
J Infect Dis
Novel therapies to counteract multidrug-resistant gonorrhea are urgently needed. A unique gonococcal immune evasion strategy involves capping of lipooligosaccharide (LOS) with sialic acid by gonococcal sialyltransferase (Lst), utilizing host-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593ecdc4ca49f48f711408adabdb9614
https://pubmed.ncbi.nlm.nih.gov/32692362
https://pubmed.ncbi.nlm.nih.gov/32692362
Autor:
Sunita, Gulati, Ian C, Schoenhofen, Theresa, Lindhout-Djukic, Melissa J, Schur, Corinna S, Landig, Sudeshna, Saha, Lingquan, Deng, Lisa A, Lewis, Bo, Zheng, Ajit, Varki, Sanjay, Ram
Publikováno v:
J Immunol
Neisseria gonorrhoeae deploys a unique immune evasion strategy wherein the lacto-N-neotetraose (LNnT) termini of lipooligosaccharide (LOS) are capped by a surface sialyltransferase (Lst), utilizing extracellular host-derived CMP-sialic acid (CMP-Neu5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3bcb3171ca6891c6eeeffda75e2c7aab
https://pubmed.ncbi.nlm.nih.gov/32434942
https://pubmed.ncbi.nlm.nih.gov/32434942
Autor:
James B. Thoden, Ian C. Schoenhofen, N. Martin Young, Peter A. Tipton, David C. Watson, Alexander S. Riegert, Hazel M. Holden
Within recent years it has become apparent that protein glycosylation is not limited to eukaryotes. Indeed, in Campylobacter jejuni, a Gram-negative bacterium, more than 60 of its proteins are known to be glycosylated. One of the sugars found in such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06888d33ca1071c8ce570c38d7b9e65
https://nrc-publications.canada.ca/eng/view/object/?id=1d867b97-0313-428f-bb5f-554a9dbfe14a
https://nrc-publications.canada.ca/eng/view/object/?id=1d867b97-0313-428f-bb5f-554a9dbfe14a
Autor:
Ian C. Schoenhofen, Yves Durocher, Paul Lopez, Michael Butler, Edward Bodnar, Céline Raymond, Hélène Perreault, Carina Villacrés
Publikováno v:
Analytical and Bioanalytical Chemistry. 407:8945-8958
Metabolic engineering of glycans present on antibodies and other glycoproteins is becoming an interesting research area for improving our understanding of the glycome. With knowledge of the sialic acid biosynthetic pathways, the experiments described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd59e4c3c1890284c2d1ff456f64cf64
https://doi.org/10.1007/s00216-015-9010-x
https://doi.org/10.1007/s00216-015-9010-x
Autor:
Sonia Leclerc, N. Martin Young, Michel Gilbert, Melissa J. Schur, Warren W. Wakarchuk, Ian C. Schoenhofen, David C. Watson
Publikováno v:
Glycobiology. 25:767-773
Legionaminic acids (Leg) are bacterial analogs of neuraminic acid, with the same stereochemistry but different substituents at C5, C7 and C9. Hence they may be incorporated into useful analogs of sialoglycoconjugates, and we previously reported two s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc02a68d436d931b7ded9be5e948355d
https://doi.org/10.1093/glycob/cwv017
https://doi.org/10.1093/glycob/cwv017
Publikováno v:
Methods in enzymology. 597
Legionaminic acids are analogs of sialic acid that occur in cell surface glycoconjugates of several bacteria. Because legionaminic acids share the same stereochemistry as sialic acid but differ at C7 and C9, they are interesting analogs to probe the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::94e1bfe2c369cf14f9fad8ac30e3dece
https://pubmed.ncbi.nlm.nih.gov/28935102
https://pubmed.ncbi.nlm.nih.gov/28935102