Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Ian B. Stanaway"'
Autor:
Insa M. Schmidt, Aditya L. Surapaneni, Runqi Zhao, Dhairya Upadhyay, Wan-Jin Yeo, Pascal Schlosser, Courtney Huynh, Anand Srivastava, Ragnar Palsson, Taesoo Kim, Isaac E. Stillman, Daria Barwinska, Jonathan Barasch, Michael T. Eadon, Tarek M. El-Achkar, Joel Henderson, Dennis G. Moledina, Sylvia E. Rosas, Sophie E. Claudel, Ashish Verma, Yumeng Wen, Maja Lindenmayer, Tobias B. Huber, Samir V. Parikh, John P. Shapiro, Brad H. Rovin, Ian B. Stanaway, Neha A. Sathe, Pavan K. Bhatraju, Josef Coresh, the Kidney Precision Medicine Project, Eugene P. Rhee, Morgan E. Grams, Sushrut S. Waikar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The kidney tubules constitute two-thirds of the cells of the kidney and account for the majority of the organ’s metabolic energy expenditure. Acute tubular injury (ATI) is observed across various types of kidney diseases and may significan
Externí odkaz:
https://doaj.org/article/41855c04b12d4c92a5497040b3021033
Autor:
Elizabeth A. Jasper, Jacklyn N. Hellwege, Joseph H. Breeyear, Brenda Xiao, Gail P. Jarvik, Ian B. Stanaway, Kathleen A. Leppig, Geetha Chittoor, M. Geoffrey Hayes, Ozan Dikilitas, Iftikhar J. Kullo, Ingrid A. Holm, Shefali Setia Verma, Todd L. Edwards, Digna R. Velez Edwards
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Preeclampsia, a pregnancy complication characterized by hypertension after 20 gestational weeks, is a major cause of maternal and neonatal morbidity and mortality. Mechanisms leading to preeclampsia are unclear; however, there is evidence of
Externí odkaz:
https://doaj.org/article/593f321d88b040258ab9f27c654b2a15
Autor:
Runa Kuley, Bhargavi Duvvuri, Jeffrey J. Wallin, Nam Bui, Mary Vic Adona, Nicholas G. O’Connor, Sharon K. Sahi, Ian B. Stanaway, Mark M. Wurfel, Eric D. Morrell, W. Conrad Liles, Pavan K. Bhatraju, Christian Lood
Publikováno v:
Virulence, Vol 14, Iss 1 (2023)
ABSTRACTNeutrophil dysregulation is well established in COVID-19. However, factors contributing to neutrophil activation in COVID-19 are not clear. We assessed if N-formyl methionine (fMet) contributes to neutrophil activation in COVID-19. Elevated l
Externí odkaz:
https://doaj.org/article/68bb341cfe6c496ea2f3d2dd7b86a2b7
Autor:
Sina A. Gharib, Louise V. Wain, Tõnu Esko, Gail P. Jarvik, Scott Hebbring, Eric B. Larson, Sarah H. Landis, Ruth J.F. Loos, Jiangyuan Liu, Caroline Hayward, Arden Moscati, Yuan Luo, Bahram Namjou, Hana Mullerova, Marjo-Riitta Järvelin, Jennifer K. Quint, Eeva Sliz, Marylyn D. Ritchie, Laurent Thomas, Ian B. Stanaway, Kristian Hveem, David Michalovich, Ian P. Hall, James F. Wilson, Jing Chen, Alexander T. Williams, Martin D. Tobin, Joanna C. Betts, Hardeep Naghra-van Gijzel, Richard Packer, Edith M. Hessel, Astrid J. Yeo, Nicola F. Reeve, Bjørn Olav Åsvold, Erik Abner, Archie Campbell, Traci M. Bartz, Juha Auvinen, Catherine John, Ben Brumpton, Yuki Bradford, Su Chu, David J. Porteous, Nick Shrine, Michael H. Cho, QiPing Feng, David R. Crosslin
Publikováno v:
Wellcome Open Research, Vol 6 (2023)
Background: Globally, respiratory infections contribute to significant morbidity and mortality. However, genetic determinants of respiratory infections are understudied and remain poorly understood. Methods: We conducted a genome-wide association stu
Externí odkaz:
https://doaj.org/article/c17a2bf7fdb5446eaddb34047fe072d7
Autor:
Lili Liu, Atlas Khan, Elena Sanchez-Rodriguez, Francesca Zanoni, Yifu Li, Nicholas Steers, Olivia Balderes, Junying Zhang, Priya Krithivasan, Robert A. LeDesma, Clara Fischman, Scott J. Hebbring, John B. Harley, Halima Moncrieffe, Leah C. Kottyan, Bahram Namjou-Khales, Theresa L. Walunas, Rachel Knevel, Soumya Raychaudhuri, Elizabeth W. Karlson, Joshua C. Denny, Ian B. Stanaway, David Crosslin, Thomas Rauen, Jürgen Floege, Frank Eitner, Zina Moldoveanu, Colin Reily, Barbora Knoppova, Stacy Hall, Justin T. Sheff, Bruce A. Julian, Robert J. Wyatt, Hitoshi Suzuki, Jingyuan Xie, Nan Chen, Xujie Zhou, Hong Zhang, Lennart Hammarström, Alexander Viktorin, Patrik K. E. Magnusson, Ning Shang, George Hripcsak, Chunhua Weng, Tatjana Rundek, Mitchell S. V. Elkind, Elizabeth C. Oelsner, R. Graham Barr, Iuliana Ionita-Laza, Jan Novak, Ali G. Gharavi, Krzysztof Kiryluk
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Immunoglobulin A protects against infectious disease and contributes to autoimmune and inflammatory disorders. Here, the authors perform a genome-wide association study for serum IgA levels, identifying 20 genome-wide significant loci, providing new
Externí odkaz:
https://doaj.org/article/a56e340c9bb948a69e4eb08fc8a4c941
Autor:
Xinyuan Zhang, Anastasia M. Lucas, Yogasudha Veturi, Theodore G. Drivas, William P. Bone, Anurag Verma, Wendy K. Chung, David Crosslin, Joshua C. Denny, Scott Hebbring, Gail P. Jarvik, Iftikhar Kullo, Eric B. Larson, Laura J. Rasmussen-Torvik, Daniel J. Schaid, Jordan W. Smoller, Ian B. Stanaway, Wei-Qi Wei, Chunhua Weng, Marylyn D. Ritchie
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Circulatory system diseases and nervous system disorders often co-occur in patients. Here the authors use eMERGE and UK BioBank data to identify genomic regions associated with both phenotypes, providing insight into the relationship between these co
Externí odkaz:
https://doaj.org/article/4e82c50b745f4c0f8cbf12c5aaa0ea67
Autor:
Yen-Chen A. Feng, Ian B. Stanaway, John J. Connolly, Joshua C. Denny, Yuan Luo, Chunhua Weng, Wei-Qi Wei, Scott T. Weiss, Elizabeth W. Karlson, Jordan W. Smoller
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background As genomic sequencing moves closer to clinical implementation, there has been an increasing acceptance of returning incidental findings to research participants and patients for mutations in highly penetrant, medically actionable
Externí odkaz:
https://doaj.org/article/1d172a6eb2b243b18252e93e437d1df3
Autor:
Pavan K. Bhatraju, MD, MSc, Eric D. Morrell, MD, Ian B. Stanaway, PhD, Neha A. Sathe, MD, MSc, Avantika Srivastava, MS, Radu Postelnicu, MD, Richard Green, BS, Adair Andrews, BSN, Martin Gonzalez, BS, Christopher J. Kratochvil, MD, Vishakha K. Kumar, BS, Tien-Ying Hsiang, PhD, Michael Gale, Jr, PhD, George L. Anesi, MD, David Wyles, MD, M. Jana Broadhurst, MD, PhD, David Brett-Major, MD, MPH, Vikramjit Mukherjee, MD, Jonathan E. Sevransky, MD, Douglas Landsittel, PhD, Chi Hung, MD, William A. Altemeier, MD, Sina A. Gharib, MD, Timothy M. Uyeki, MD, MPH, J. Perren Cobb, MD, Janice M. Liebler, MD, David R. Crosslin, PhD, Gail P. Jarvik, MD, Leopoldo N. Segal, MD, Laura Evans, MD, Carmen Mikacenic, MD, Mark M. Wurfel, MD, PhD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 1, p e0827 (2023)
IMPORTANCE:. Vascular dysfunction and capillary leak are common in critically ill COVID-19 patients, but identification of endothelial pathways involved in COVID-19 pathogenesis has been limited. Angiopoietin-like 4 (ANGPTL4) is a protein secreted in
Externí odkaz:
https://doaj.org/article/de84ce123a564b7b9fa872a7b541c824
Autor:
Minoo Bagheri, Chuan Wang, Mingjian Shi, Ali Manouchehri, Katherine T. Murray, Matthew B. Murphy, Christian M. Shaffer, Kritika Singh, Lea K. Davis, Gail P. Jarvik, Ian B. Stanaway, Scott Hebbring, Muredach P. Reilly, Robert E. Gerszten, Thomas J. Wang, Jonathan D. Mosley, Jane F. Ferguson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Inflammation increases the risk of cardiometabolic disease. Delineating specific inflammatory pathways and biomarkers of their activity could identify the mechanistic underpinnings of the increased risk. Plasma levels of kynurenine, a metabo
Externí odkaz:
https://doaj.org/article/82d713fe6c8546188c145b33545e9251
Autor:
Ning Shang, Atlas Khan, Fernanda Polubriaginof, Francesca Zanoni, Karla Mehl, David Fasel, Paul E. Drawz, Robert J. Carrol, Joshua C. Denny, Matthew A. Hathcock, Adelaide M. Arruda-Olson, Peggy L. Peissig, Richard A. Dart, Murray H. Brilliant, Eric B. Larson, David S. Carrell, Sarah Pendergrass, Shefali Setia Verma, Marylyn D. Ritchie, Barbara Benoit, Vivian S. Gainer, Elizabeth W. Karlson, Adam S. Gordon, Gail P. Jarvik, Ian B. Stanaway, David R. Crosslin, Sumit Mohan, Iuliana Ionita-Laza, Nicholas P. Tatonetti, Ali G. Gharavi, George Hripcsak, Chunhua Weng, Krzysztof Kiryluk
Publikováno v:
npj Digital Medicine, Vol 4, Iss 1, Pp 1-13 (2021)
Abstract Chronic Kidney Disease (CKD) represents a slowly progressive disorder that is typically silent until late stages, but early intervention can significantly delay its progression. We designed a portable and scalable electronic CKD phenotype to
Externí odkaz:
https://doaj.org/article/24b3c498eb59459db6ee0b4a55ddf3e3