Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Ian B. Seiple"'
Autor:
Roberto Efraín Díaz, Andrew K Ecker, Galen J Correy, Pooja Asthana, Iris D Young, Bryan Faust, Michael C Thompson, Ian B Seiple, Steven Van Dyken, Richard M Locksley, James S Fraser
Publikováno v:
eLife, Vol 12 (2024)
Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of these proteins, Acidic Mamma
Externí odkaz:
https://doaj.org/article/1d6ac3d5e2914957b1f145449e49bd88
Publikováno v:
ACS Chemical Biology. 17:1259-1268
Targeted protein degradation is a promising therapeutic strategy capable of overcoming the limitations of traditional occupancy-based inhibitors. By ablating all of the associated functions of a protein at once, the event-driven pharmacology of degra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03c38b3a2d49099ee84b79572d60127
https://doi.org/10.1021/acschembio.2c00185
https://doi.org/10.1021/acschembio.2c00185
Publikováno v:
ACS Chemical Biology. 17:3270-3275
Biotin is a common functional handle for bioconjugation to proteins and DNA, but its uses are limited to protein-containing conjugation partners such as streptavidin and derivatives thereof. Recently, oxaziridine reagents were developed that selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceea87d9ab66e6168874357697432bfa
https://doi.org/10.1021/acschembio.1c00252
https://doi.org/10.1021/acschembio.1c00252
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, vol 143, iss 2
Journal of the American Chemical Society, vol 143, iss 2
Targeted protein degradation has emerged as a new paradigm to manipulate cellular proteostasis. Proteolysis-targeting chimeras (PROTACs) are bifunctional small molecules that recruit an E3 ligase to a target protein of interest, promoting its ubiquit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b40b0b6e9e04a2e685343948e864c8
http://europepmc.org/articles/PMC8154509
http://europepmc.org/articles/PMC8154509
Publikováno v:
Antimicrobial agents and chemotherapy. 66(5)
The World Health Organization (WHO) has warned that our current arsenal of antibiotics is not innovative enough to face impending infectious diseases, especially those caused by multidrug-resistant Gram-negative pathogens. Although the current precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9aa9787bdfe0cbaca0ba30e8217e087
https://pubmed.ncbi.nlm.nih.gov/35471042
https://pubmed.ncbi.nlm.nih.gov/35471042
Autor:
Bhairavi Tolani, Anna Celli, Yanmin Yao, Yong Zi Tan, Richard Fetter, Christina R. Liem, Adam J. de Smith, Thamiya Vasanthakumar, Paola Bisignano, Adam D. Cotton, Ian B. Seiple, John L. Rubinstein, Marco Jost, Jonathan S. Weissman
Publikováno v:
Nature biotechnology, vol 40, iss 12
Mutations in Ras family proteins are implicated in 33% of human cancers, but direct pharmacological inhibition of Ras mutants remains challenging. As an alternative to direct inhibition, we screened for sensitivities in Ras-mutant cells and discovere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a71129bb71ed4aab46b2badda735d5
https://pubmed.ncbi.nlm.nih.gov/35879364
https://pubmed.ncbi.nlm.nih.gov/35879364
Autor:
Xiaoyu Shi, Qi Li, Zhipeng Dai, Arthur A. Tran, Siyu Feng, Alejandro D. Ramirez, Zixi Lin, Xiaomeng Wang, Tracy T. Chow, Jiapei Chen, Dhivya Kumar, Andrew R. McColloch, Jeremy F. Reiter, Eric J. Huang, Ian B. Seiple, Bo Huang
Publikováno v:
The Journal of cell biology, vol 220, iss 9
Expansion microscopy (ExM) increases the effective resolving power of any microscope by expanding the sample with swellable hydrogel. Since its invention, ExM has been successfully applied to a wide range of cell, tissue and animal samples. Still, fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019298925ec3a3278354b13e299625f3
https://escholarship.org/uc/item/3zh5s48c
https://escholarship.org/uc/item/3zh5s48c
Autor:
Bo Huang, Zhipeng Dai, Xiaoyu Shi, Xiaomeng Wang, Dhivya Ashok Kumar, Tracy T. Chow, Alejandro Ramirez, Jeremy F. Reiter, Eric J. Huang, Andrew McColloch, Qi Li, Siyu Feng, Zixi Lin, Ian B. Seiple, Arthur A Tran, Jiapei Chen
Publikováno v:
Journal of Cell Biology. 220
Expansion microscopy (ExM) increases the effective resolving power of any microscope by expanding the sample with swellable hydrogel. Since its invention, ExM has been successfully applied to a wide range of cell, tissue, and animal samples. Still, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1c11916e7eda751120773e94899e9b
https://doi.org/10.1083/jcb.202105067
https://doi.org/10.1083/jcb.202105067
Autor:
Ian B. Seiple, Qi Li
Publikováno v:
Tetrahedron, vol 75, iss 24
Tetrahedron
Tetrahedron
Modular, fully synthetic routes to structurally complex natural products provide useful avenues to access chemical diversity. Herein we report a concise route to virginiamycin M2, a member of the group A streptogramin class of natural products that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a6f3fe867c80136b06eea4500aea25
https://doi.org/10.1016/j.tet.2019.04.060
https://doi.org/10.1016/j.tet.2019.04.060
Autor:
Ian B. Seiple, Su Guo, Jason Q. Garcia, Kai Tong, Zhipeng Dai, Bin Yang, Qi Li, Bo Huang, Xiaoyu Shi, Xingye Chen, Xiang Zhao
Publikováno v:
Science advances, vol 7, iss 24
Science Advances
Science Advances
In vivo imaging and expansion microscopy reveal a new role of cytosolic Par-3 in polarized transport of Notch signaling endosome.
In the developing embryos, the cortical polarity regulator Par-3 is critical for establishing Notch signaling asymm
In the developing embryos, the cortical polarity regulator Par-3 is critical for establishing Notch signaling asymm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba901e1ad5ffba61b63f4d62ad0f5e56
https://escholarship.org/uc/item/1nc9n4v2
https://escholarship.org/uc/item/1nc9n4v2