Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ian B. Pragnell"'
Autor:
Anne N. Parker, Ian B. Pragnell
Publikováno v:
Hematology (Amsterdam, Netherlands). 2(4)
Macrophage inflammatory protein - 1 alpha (MIP-1α) is an 8kD protein which tends to form aggregates and is a member of the C-X-C chemokine subfamily, being a pro-inflammatory agent and is chemotactic for lymphocytes. MIP-1α has been shown to inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cec508d5c02fe3c9ba252af7009e9c
https://pubmed.ncbi.nlm.nih.gov/27405236
https://pubmed.ncbi.nlm.nih.gov/27405236
Autor:
Kay Samuel, Mary G. Freshney, Eric G. Wright, Ian B. Pragnell, Tessa L. Holyoake, Gwyneth E. Watson, Gerard J. Graham, J. D. Ansell
Publikováno v:
British Journal of Haematology. 114:49-56
Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5+ B cells. This B-cell lineage is established during ontogeny and replenished by the process of self-renewal. Spontaneous and induced leukaemias that frequently affect this lineage are thought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d425ef0429c892858d25faa1e8dffc
https://doi.org/10.1046/j.1365-2141.2001.02903.x
https://doi.org/10.1046/j.1365-2141.2001.02903.x
Publikováno v:
Transplantation. 67:1348-1357
Background. The ex vivo expansion of hematopoietic grafts has been proposed as an efficient procedure for improving the hematological recovery of recipients. The fate of the long-term repopulating cells during the ex vivo manipulation of the graft is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e0896b5d672e70de14c6683b85e347f
https://doi.org/10.1097/00007890-199905270-00010
https://doi.org/10.1097/00007890-199905270-00010
Publikováno v:
Journal of Biological Chemistry. 272:12495-12504
The β-chemokine macrophage inflammatory protein-1α (MIP-1α) is chemotactic for many hemopoietic cell types and can inhibit hemopoietic stem cell (HSC) proliferation, effects mediated through G-protein coupled heptahelical receptors. We have isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51e0dfeaa4d7377d8e366a8971a629c7
https://doi.org/10.1074/jbc.272.19.12495
https://doi.org/10.1074/jbc.272.19.12495
Autor:
Gerry Graham, Ian B. Pragnell, S. O. Kolset, A. Parker, M. G. Freshney, P. C. Wilkinson, Robert J. B. Nibbs, S. Lowe, Monica Lik-Shing Tsang
Publikováno v:
The EMBO Journal. 15:6506-6515
We have studied the role of proteoglycans in the function of Macrophage Inflammatory Protein-1 alpha (MIP-1alpha), a member of the proteoglycan binding chemokine family. Sequence and peptide analysis has identified a basic region within MIP-1alpha wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e01e71a2edcc420e6c5dbd99d185ec5c
https://doi.org/10.1002/j.1460-2075.1996.tb01041.x
https://doi.org/10.1002/j.1460-2075.1996.tb01041.x
Autor:
William P. Steward, Gerard J. Graham, Tessa L. Holyoake, Mary G. Freshney, Ian B. Pragnell, Anne Parker, Lorna McNair, Pamela McKay, Edward Fitzsimons
Publikováno v:
Blood. 87:4589-4595
The characterization of many cytokines involved in the control of hematopoiesis has led to intense investigation into their potential use in ex vivo culture to expand progenitor numbers. We have established the optimum ex vivo culture conditions that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1340d81048040c0d4b83043d280bc8e1
https://doi.org/10.1182/blood.v87.11.4589.bloodjournal87114589
https://doi.org/10.1182/blood.v87.11.4589.bloodjournal87114589
Autor:
F Fang, A Issacson, Ian B. Pragnell, J Medicherla, Jane MacKenzie, Gerard J. Graham, P. C. Wilkinson, S. Lowe, Monica Lik-Shing Tsang, James A. Weatherbee
Publikováno v:
Journal of Biological Chemistry. 269:4974-4978
Macrophage inhibitory protein (MIP)-1 alpha is a potent inhibitor of hemopoietic stem cell proliferation and is a member of a family of pro-inflammatory mediators, the chemokine family. This molecule along with other members of the chemokine family e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db384e55f8b60d9850040a4a0597a2b6
https://doi.org/10.1016/s0021-9258(17)37641-x
https://doi.org/10.1016/s0021-9258(17)37641-x
Autor:
Julie E. Burns, Christine Heufler, Ian B. Pragnell, Gerard J. Graham, E Kenneth Parkinson, Mark Plumb, Gerold Schuler, Pierre Daubersies
Publikováno v:
Journal of Investigative Dermatology. 101(2):113-117
The maintenance and regulation of continuously renewing tissues is ultimately controlled at the level of stem-cell proliferation. We have recently identified a reversible inhibitor of hemopoietic stem-cell proliferation (stem-cell inhibitor [SCI]), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2da754c217be61e5d33712f09f25fc
Autor:
Ian B. Pragnell, Valérie F. J. Quesniaux, Deborah Donaldson, Barbara Fagg, Stephen D. Wolpe, Gerry Graham, Norman N. Iscove
Publikováno v:
Blood. 81:1497-1504
A macrophage-derived inhibitor of early hematopoietic progenitors (colony-forming unit-spleen, CFU-A) called stem cell inhibitor was found to be identical to macrophage inflammatory protein-1 alpha (MIP-1 alpha). We investigated the effect of MIP-1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98141b6c43d7850c30535475e6994f7c
https://doi.org/10.1182/blood.v81.6.1497.1497
https://doi.org/10.1182/blood.v81.6.1497.1497
Autor:
Gerard J. Graham, Ian B. Pragnell
Publikováno v:
Seminars in Cell Biology. 3:423-434
All the cells of the immuno-haemopoietic system derive ultimately from a single pluripotent stem cell through processes of commitment and differentiation. The stem cell is also likely to be capable of extensive self renewal. Many factors which potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c07851a6afd6ad4e8d9ddc2021e38e8
https://doi.org/10.1016/1043-4682(92)90013-l
https://doi.org/10.1016/1043-4682(92)90013-l