Výsledky vyhledávání - "Ian B. Pragnell"

Periodical

Review of Culture of Haematopoietic Cells, by R.Ian Freshney, Ian B. Pragnell and Mary G. Freshney

Publikováno v: Cell Biology International; January 1995, Vol. 19 Issue: 1 p79-80, 2p

Macrophage Inflammatory Protein-1 Alpha: A Paradox?

Publikováno v: Hematology (Amsterdam, Netherlands). 2(4)

Macrophage inflammatory protein - 1 alpha (MIP-1α) is an 8kD protein which tends to form aggregates and is a member of the C-X-C chemokine subfamily, being a pro-inflammatory agent and is chemotactic for lymphocytes. MIP-1α has been shown to inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cec508d5c02fe3c9ba252af7009e9c
https://pubmed.ncbi.nlm.nih.gov/27405236

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In vivoexpansion of the endogenous B-cell compartment stimulated by radiation and serial bone marrow transplantation induces B-cell leukaemia in mice

Autor: Kay Samuel, Mary G. Freshney, Eric G. Wright, Ian B. Pragnell, Tessa L. Holyoake, Gwyneth E. Watson, Gerard J. Graham, J. D. Ansell

Publikováno v: British Journal of Haematology. 114:49-56

Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5+ B cells. This B-cell lineage is established during ontogeny and replenished by the process of self-renewal. Spontaneous and induced leukaemias that frequently affect this lineage are thought

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16d425ef0429c892858d25faa1e8dffc
https://doi.org/10.1046/j.1365-2141.2001.02903.x

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PRESERVED LONG-TERM REPOPULATION AND DIFFERENTIATION PROPERTIES OF HEMATOPOIETIC GRAFTS SUBJECTED TO EX VIVO EXPANSION WITH STEM CELL FACTOR AND INTERLEUKIN 111

Autor: Ian B. Pragnell, Guillermo Guenechea, Beatriz Albella, Juan A. Bueren, José C. Segovia

Publikováno v: Transplantation. 67:1348-1357

Background. The ex vivo expansion of hematopoietic grafts has been proposed as an efficient procedure for improving the hematological recovery of recipients. The fate of the long-term repopulating cells during the ex vivo manipulation of the graft is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e0896b5d672e70de14c6683b85e347f
https://doi.org/10.1097/00007890-199905270-00010

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Cloning and Characterization of a Novel Murine β Chemokine Receptor, D6

Autor: Shaeron M. Wylie, Gerard J. Graham, Robert J. B. Nibbs, Ian B. Pragnell

Publikováno v: Journal of Biological Chemistry. 272:12495-12504

The β-chemokine macrophage inflammatory protein-1α (MIP-1α) is chemotactic for many hemopoietic cell types and can inhibit hemopoietic stem cell (HSC) proliferation, effects mediated through G-protein coupled heptahelical receptors. We have isolat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51e0dfeaa4d7377d8e366a8971a629c7
https://doi.org/10.1074/jbc.272.19.12495

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Uncoupling of stem cell inhibition from monocyte chemoattraction in MIP-1alpha by mutagenesis of the proteoglycan binding site

Autor: Gerry Graham, Ian B. Pragnell, S. O. Kolset, A. Parker, M. G. Freshney, P. C. Wilkinson, Robert J. B. Nibbs, S. Lowe, Monica Lik-Shing Tsang

Publikováno v: The EMBO Journal. 15:6506-6515

We have studied the role of proteoglycans in the function of Macrophage Inflammatory Protein-1 alpha (MIP-1alpha), a member of the proteoglycan binding chemokine family. Sequence and peptide analysis has identified a basic region within MIP-1alpha wh

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https://doi.org/10.1002/j.1460-2075.1996.tb01041.x

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Ex vivo expansion with stem cell factor and interleukin-11 augments both short-term recovery posttransplant and the ability to serially transplant marrow

Autor: William P. Steward, Gerard J. Graham, Tessa L. Holyoake, Mary G. Freshney, Ian B. Pragnell, Anne Parker, Lorna McNair, Pamela McKay, Edward Fitzsimons

Publikováno v: Blood. 87:4589-4595

The characterization of many cytokines involved in the control of hematopoiesis has led to intense investigation into their potential use in ex vivo culture to expand progenitor numbers. We have established the optimum ex vivo culture conditions that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1340d81048040c0d4b83043d280bc8e1
https://doi.org/10.1182/blood.v87.11.4589.bloodjournal87114589

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Aggregation of the chemokine MIP-1 alpha is a dynamic and reversible phenomenon. Biochemical and biological analyses

Autor: F Fang, A Issacson, Ian B. Pragnell, J Medicherla, Jane MacKenzie, Gerard J. Graham, P. C. Wilkinson, S. Lowe, Monica Lik-Shing Tsang, James A. Weatherbee

Publikováno v: Journal of Biological Chemistry. 269:4974-4978

Macrophage inhibitory protein (MIP)-1 alpha is a potent inhibitor of hemopoietic stem cell proliferation and is a member of a family of pro-inflammatory mediators, the chemokine family. This molecule along with other members of the chemokine family e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db384e55f8b60d9850040a4a0597a2b6
https://doi.org/10.1016/s0021-9258(17)37641-x

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Hemopoietic Stem Cell Inhibitor (SCI/MIP-1∝) Also Inhibits Clonogenic Epidermal Keratinocyte Proliferation

Autor: Julie E. Burns, Christine Heufler, Ian B. Pragnell, Gerard J. Graham, E Kenneth Parkinson, Mark Plumb, Gerold Schuler, Pierre Daubersies

Publikováno v: Journal of Investigative Dermatology. 101(2):113-117

The maintenance and regulation of continuously renewing tissues is ultimately controlled at the level of stem-cell proliferation. We have recently identified a reversible inhibitor of hemopoietic stem-cell proliferation (stem-cell inhibitor [SCI]), w

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