Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ian B. Moses"'
Autor:
Ian B. Moses, Neal W. Sach, Loïc R E Pantaine, Andre Shavnya, David C. Blakemore, Xinlan A F Cook, Michael C. Willis
Publikováno v:
Angewandte Chemie (International Ed. in English)
Heteroaromatic sulfinates are effective nucleophilic reagents in Pd0‐catalyzed cross‐coupling reactions with aryl halides. However, metal sulfinate salts can be challenging to purify, solubilize in reaction media, and are not tolerant to multi‐
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926f4bf73e208897e440065cbc4d1190
http://europepmc.org/articles/PMC8518705
http://europepmc.org/articles/PMC8518705
Autor:
Janette McKnight, Andre Shavnya, Neal W. Sach, David C. Blakemore, Ian B. Moses, Michael C. Willis
An efficient Pd-catalyzed one-pot desulfinative cross-coupling to access medicinally relevant di(hetero)arylmethanes is reported. The method is reductant-free, and involves a sulfinate transfer reagent and a Pd-catalyst mediating the union of two ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e95feaf513ca29b2860e3f04451000
https://ora.ox.ac.uk/objects/uuid:5b1f7d51-3f8e-4d6d-8a88-c2c898529e93
https://ora.ox.ac.uk/objects/uuid:5b1f7d51-3f8e-4d6d-8a88-c2c898529e93
Publikováno v:
Organic Process Research & Development. 16:697-703
The development and implementation of a safe and scalable process for the manufacture of corticosteroid PF-4714224 (1) is described. Initial routes used to synthesise analogues from this series directly from fluocinolone acetonide (2) were unsuitable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb68d854c69797caca4c82fa87d14081
https://doi.org/10.1021/op200257g
https://doi.org/10.1021/op200257g
Autor:
Alan John Pettman, Nieves Castro, Iain Robert Gladwell, Ian B. Moses, Natalie A. Morrison, Maninder S. Panesar, Nicholas Murray Thomson, Pieter D. de Koning
Publikováno v:
Organic Process Research & Development. 15:1256-1265
The development of a practical, scalable route to PF-00610355 (8) is described. In this convergent approach, amine 9 is coupled to protected bromohydrin 1 to give the doubly protected intermediate 26. TBS-Deprotection of 26 affords the benzyl protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e1470e98fe2368ffa01e135a9a795b4
https://doi.org/10.1021/op2002408
https://doi.org/10.1021/op2002408
Autor:
Iain Robert Gladwell, Ian B. Moses, Nicholas Murray Thomson, Maninder S. Panesar, Alan John Pettman, Pieter D. de Koning
Publikováno v:
Organic Process Research & Development. 15:1247-1255
The initial route used to prepare PF-00610355 (8) for early clinical development is described. Through careful choice of solvent, an efficient, telescoped route to carboxylic acid 23 was developed, affording this late-stage intermediate in 80% yield
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef178697153d9bcbc018eee494d246fc
https://doi.org/10.1021/op2001904
https://doi.org/10.1021/op2001904
Autor:
Andrew J. Bibb, Petar I. Nikiforov, Stuart Field, Steven J. Fussell, Olivier Dirat, Mason Clive Philip, Alan John Pettman, Colin M. Burns, Green Stuart, Ian B. Moses, Jinu S. Mathew, Graham Checksfield, Barry Richard Dillon, Flavien Susanne, Suju Mathew
Publikováno v:
Organic Process Research & Development. 15:1010-1017
We report the discovery and optimization of an amine-promoted Friedel–Crafts alkylation of cinnamaldehyde with 4-hydroxymethyl phenol. This reaction has been used successfully on commercial scale (200 kg) in the context of the manufacture of fesote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac12c5d6e2599650d59bca0d61c550ab
https://doi.org/10.1021/op200107g
https://doi.org/10.1021/op200107g
Autor:
Ian B. Moses, Rick Rodriguez, Peter Robert Rose, Corey L. Stanchina, Cuthbertson Timothy J, Asayuki Kamatani, Pieter D. de Koning, Alison Sandoval, Kyle Kissick, Robert Moore, Leera Rahman, Douglas McAndrew, Armando Urbina, David C. Boyles
Publikováno v:
Organic Process Research & Development. 15:1018-1026
A robust six-step process for the synthesis of crizotinib, a novel c-Met/ALK inhibitor currently in phase III clinical trials, has been developed and used to deliver over 100 kg of API. The process includes a Mitsunobu reaction, a chemoselective redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fd5a1469f77db90ff994ded3cb5273e
https://doi.org/10.1021/op200131n
https://doi.org/10.1021/op200131n
Autor:
Alan John Pettman, Daniel R. Yazbeck, Maninder S. Panesar, Nicholas Murray Thomson, Ian B. Moses, Iain Robert Gladwell, Pieter D. de Koning, Natalie A. Morrison
Publikováno v:
Organic Process Research & Development. 15:871-875
An efficient process to ethyl [3-(2-amino-2-methylpropyl)phenyl]acetate 6 has been developed. Key steps include a novel enzymatic desymmetrization of diester 2 and a Ritter reaction between alcohol...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eae29c37bee97d64db0912c91bafab7b
https://doi.org/10.1021/op200108k
https://doi.org/10.1021/op200108k
Autor:
Ian B. Moses, M. Jonathan Fray, Adam T. Gillmore, Keith A. Reeves, Lisa R. Thompson, Melanie S. Glossop, David J. McManus, Céline F. B. Praquin
Publikováno v:
Organic Process Research & Development. 14:263-271
The development is described of a viable kilo-scale synthesis of the Nav1.8 sodium channel modulator, N-methyl-6-amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide (PF-1247324) in five steps, starting from 6-amino-5-bromo-2-picoline, in 33% overal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a356863667163c037ec41c1cc47c6278
https://doi.org/10.1021/op900092h
https://doi.org/10.1021/op900092h
Autor:
Pieter D. de Koning, Nieves Castro, Iain R. Gladwell, Natalie A. Morrison, Ian B. Moses, Maninder S. Panesar, Alan J. Pettman, Nicholas M. Thomson
Publikováno v:
Organic Process Research & Development; Nov2011, Vol. 15 Issue 6, p1256-1265, 10p