Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ian B. Greenberg"'
Autor:
Nancy E. Kohl, Kenneth S. Koblan, Ronald G. Robinson, Samuel L. Graham, Hans E. Huber, Robert B. Lobell, Carolyn A. Buser, Jeffrey M. Bergman, Theresa M. Williams, George D. Hartman, Marc Abrams, Joseph P. Davide, Ian B Greenberg, Christopher J. Dinsmore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1411-1415
A series of aryloxy substituted piperazinones with dual farnesyltransferase/geranylgeranyltransferase-I inhibitory activity was prepared. These compounds were found to have potent inhibitory activity in vitro and are promising agents for the inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7a4119f5e3cb9ac8d031857c2b4cd6
https://doi.org/10.1016/s0960-894x(01)00240-2
https://doi.org/10.1016/s0960-894x(01)00240-2
Autor:
I.-W. Chen, Kenneth S. Koblan, George D. Hartman, Robert B. Lobell, Theresa M. Williams, Samuel L. Graham, Jackson B. Gibbs, Ian B Greenberg, Debra A. McLoughlin, Dongming Liu, Jeffrey M. Bergman, Timothy V. Olah, C. Blair Zartman, Donna Wei, Timothy J. O'Neill, Joseph P. Davide, Nancy E. Kohl, Christopher J. Dinsmore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:537-540
The evaluation of SAR associated with the insertion of carbonyl groups at various positions of N-arylpiperazinone farnesyltransferase inhibitors is described herein. 1-Aryl-2,3-diketopiperazine derivatives exhibited the best balance of potency and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81443e20c905a2a51041cf95b6156e5
https://doi.org/10.1016/s0960-894x(00)00710-1
https://doi.org/10.1016/s0960-894x(00)00710-1
Autor:
Mark Cardamone-Rayner, Lewis A. Jacobson, Lisa A. Zdinak, Ian B. Greenberg, James J. Hartman, Nathaniel J. Szewczyk, Sami J. Barmada
Publikováno v:
Journal of Cellular Biochemistry. 67:143-153
The product of an integrated transgene provides a convenient and cell-specific reporter of intracellular protein catabolism in 103 muscle cells of the nematode Caenorhabditis elegans. The transgene is an in-frame fusion of a 5′-region of the C. ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4efbf4e50d28077e6ccca47c81be4e03
https://doi.org/10.1002/(sici)1097-4644(19971001)67:1<143::aid-jcb15>3.0.co
https://doi.org/10.1002/(sici)1097-4644(19971001)67:1<143::aid-jcb15>3.0.co
Publikováno v:
The Journal of Cell Biology
Hong Kong University of Science and Technology
Hong Kong University of Science and Technology
In situ hybridization of chick cultured muscle cells using exonic DNA probes for both AChR alpha-sub-unit and the catalytic subunit of AChE, revealed major differences in the distribution of label both over nuclei and in their surrounding cytoplasm,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a810eb29a6292053b8066bbcc91ea07
https://doi.org/10.1083/jcb.118.5.1201
https://doi.org/10.1083/jcb.118.5.1201
Autor:
Scott D. Mosser, Christine Fernandes, Eileen S. Walsh, Theresa M. Williams, Ian B Greenberg, Kelly Hamilton, Carolyn A. Buser, Kenneth S. Koblan, Christopher J. Dinsmore
Publikováno v:
Analytical biochemistry. 290(1)
Cellular transformation by Ras oncoproteins requires the posttranslation modification of farnesylation in a reaction catalyzed by farnesyl protein transferase (FPTase). Thus, inhibitors of FPTase have been developed as potential anticancer agents. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad4079ec4337f465deac31e21776687
https://pubmed.ncbi.nlm.nih.gov/11180946
https://pubmed.ncbi.nlm.nih.gov/11180946
Autor:
Theresa M. Williams, Jeffrey M. Bergman, Karen Brashear, Michael J. Breslin, Christopher J. Dinsmore, John H. Hutchinson, Suzanne C. MacTough, Craig A. Stump, Donna D. Wei, C. Blair Zartman, Michael J. Bogusky, J. Christopher Culberson, Carolyn Buser-Doepner, Joseph Davide, Ian B. Greenberg, Kelly A. Hamilton, Kenneth S. Koblan, Nancy E. Kohl, Dongming Liu, Robert B. Lobell, Scott D. Mosser, Timothy J. O'Neill, Elaine Rands, Michael D. Schaber, Francine Wilson, Edith Senderak, Sherri L. Motzel, Jackson B. Gibbs, Samuel L. Graham, David C. Heimbrook, George D. Hartman, Allen I. Oliff, Joel R. Huff
Publikováno v:
Journal of medicinal chemistry. 42(19)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9aa6dfaa30c010acc003d699cbd1f8
https://pubmed.ncbi.nlm.nih.gov/10508426
https://pubmed.ncbi.nlm.nih.gov/10508426