Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Ian B, Malone"'
Autor:
Heidi Murray-Smith, Suzie Barker, Frederik Barkhof, Josephine Barnes, Thomas M. Brown, Gabriella Captur, Molly R.E.Cartlidge, David M. Cash, William Coath, Daniel Davis, John C. Dickson, James Groves, Alun D. Hughes, Sarah-Naomi James, Ashvini Keshavan, Sarah E. Keuss, Josh King-Robson, Kirsty Lu, Ian B. Malone, Jennifer M. Nicholas, Alicja Rapala, Catherine J. Scott, Rebecca Street, Carole H. Sudre, David L. Thomas, Andrew Wong, Selina Wray, Henrik Zetterberg, Nishi Chaturvedi, Nick C. Fox, Sebastian J. Crutch, Marcus Richards, Jonathan M. Schott
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-21 (2024)
Abstract Background Although age is the biggest known risk factor for dementia, there remains uncertainty about other factors over the life course that contribute to a person’s risk for cognitive decline later in life. Furthermore, the pathological
Externí odkaz:
https://doaj.org/article/9fdd7c07f6e74bf4bc709c0fc60fb7cd
Autor:
Antoinette O’Connor, David M. Cash, Teresa Poole, Pawel J. Markiewicz, Maggie R. Fraser, Ian B. Malone, Jieqing Jiao, Philip S. J. Weston, Shaney Flores, Russ Hornbeck, Eric McDade, Michael Schöll, Brian A. Gordon, Randall J. Bateman, Tammie L. S. Benzinger, Nick C. Fox
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-11 (2023)
Abstract Cortical tau accumulation is a key pathological event that partly defines Alzheimer’s disease (AD) onset and is associated with cognitive decline and future disease progression. However, an improved understanding of the timing and pattern
Externí odkaz:
https://doaj.org/article/555f699f8f0e43d889b6f8d82c8b8ed1
Autor:
Rebecca E. Green, Jodie Lord, Marzia A. Scelsi, Jin Xu, Andrew Wong, Sarah Naomi-James, Alex Handy, Lachlan Gilchrist, Dylan M. Williams, Thomas D. Parker, Christopher A. Lane, Ian B. Malone, David M. Cash, Carole H. Sudre, William Coath, David L. Thomas, Sarah Keuss, Richard Dobson, Cristina Legido-Quigley, Nick C. Fox, Jonathan M. Schott, Marcus Richards, Petroula Proitsi, The Insight 46 study team
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background Identifying blood-based signatures of brain health and preclinical pathology may offer insights into early disease mechanisms and highlight avenues for intervention. Here, we systematically profiled associations between blood meta
Externí odkaz:
https://doaj.org/article/f5a5b80764c34bc1b3fd5049c6dcb527
Autor:
William Coath, Marc Modat, M. Jorge Cardoso, Pawel J. Markiewicz, Christopher A. Lane, Thomas D. Parker, Ashvini Keshavan, Sarah M. Buchanan, Sarah E. Keuss, Matthew J. Harris, Ninon Burgos, John Dickson, Anna Barnes, David L. Thomas, Daniel Beasley, Ian B. Malone, Andrew Wong, Kjell Erlandsson, Benjamin A. Thomas, Michael Schöll, Sebastien Ourselin, Marcus Richards, Nick C. Fox, Jonathan M. Schott, David M. Cash, for the Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract INTRODUCTION The Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As Centiloids were created using PET/computerized tomography (CT) data and are influenced by
Externí odkaz:
https://doaj.org/article/89fc878da77c45b0abc21824ecd8a625
Autor:
Qiling He, Lin Shi, Yishan Luo, Chao Wan, Ian B. Malone, Vincent C. T. Mok, James H. Cole, Melis Anatürk
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
BackgroundAutomated tools for characterising dementia risk have the potential to aid in the diagnosis, prognosis, and treatment of Alzheimer’s disease (AD). Here, we examined a novel machine learning-based brain atrophy marker, the AD-resemblance a
Externí odkaz:
https://doaj.org/article/e1947ed1504a4de183fbd62dc5792f30
Autor:
Christopher A. Lane, Josephine Barnes, Jennifer M. Nicholas, John W. Baker, Carole H. Sudre, David M. Cash, Thomas D. Parker, Ian B. Malone, Kirsty Lu, Sarah-Naomi James, Ashvini Keshavan, Sarah Buchanan, Sarah Keuss, Heidi Murray-Smith, Andrew Wong, Elizabeth Gordon, William Coath, Marc Modat, David Thomas, Rebecca Hardy, Marcus Richards, Nick C. Fox, Jonathan M. Schott
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2021)
Abstract Background In view of reported associations between high adiposity, particularly in midlife and late-life dementia risk, we aimed to determine associations between body mass index (BMI), and BMI changes across adulthood and brain structure a
Externí odkaz:
https://doaj.org/article/10e2a7dba0b142c4a8c65a142938d773
Autor:
Sarah‐Naomi James, Jennifer M. Nicholas, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Ashvini Keshavan, Sarah M. Buchanan, Sarah E. Keuss, Heidi Murray‐Smith, Andrew Wong, David M. Cash, Ian B. Malone, Josephine Barnes, Carole H. Sudre, William Coath, Lloyd Prosser, Sebastien Ourselin, Marc Modat, David L. Thomas, Jorge Cardoso, Amanda Heslegrave, Henrik Zetterberg, Sebastian J. Crutch, Jonathan M. Schott, Marcus Richards, Nick C. Fox
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 4, Pp 842-856 (2021)
Abstract Objective To assess associations between head injury (HI) with loss of consciousness (LOC), ageing and markers of later‐life cerebral pathology; and to explore whether those effects may help explain subtle cognitive deficits in dementia‐
Externí odkaz:
https://doaj.org/article/f1db91f3d9084dcca21faecff35979d1
Autor:
Patrick G Kehoe, Nicholas Turner, Beth Howden, Lina Jarutyt, Shona L Clegg, Ian B Malone, Josephine Barnes, Casper Nielsen, Carole H Sudre, Aileen Wilson, N Jade Thai, Peter S Blair, Elizabeth J Coulthard, J Athene Lane, Peter Passmore, Jodi Taylor, Henk-Jan Mutsaerts, David L Thomas, Nick C Fox, Ian Wilkinson, Yoav Ben-Shlomo
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 8, Iss 19 (2021)
Background: Medications that modify the renin–angiotensin system may reduce Alzheimer’s disease pathology and reduce the rate of disease progression. Objective: This study investigated whether taking the antihypertensive drug losartan, in additio
Externí odkaz:
https://doaj.org/article/81e153bea7a84db597fe5cde3dbfd1f0
Autor:
Sarah-Naomi James, Jennifer M. Nicholas, Kirsty Lu, Ashvini Keshavan, Christopher A. Lane, Thomas Parker, Sarah M. Buchanan, Sarah E. Keuss, Heidi Murray-Smith, Andrew Wong, David M. Cash, Ian B. Malone, Josephine Barnes, Carole H. Sudre, William Coath, Marc Modat, Sebastien Ourselin, Sebastian J. Crutch, Diana Kuh, Nick C. Fox, Jonathan M. Schott, Marcus Richards
Publikováno v:
Neurobiology of Aging, 122, 22-32. Elsevier Inc.
James, S-N, Nicholas, J M, Lu, K, Keshavan, A, Lane, C A, Parker, T, Buchanan, S M, Keuss, S E, Murray-Smith, H, Wong, A, Cash, D M, Malone, I B, Barnes, J, Sudre, C H, Coath, W, Modat, M, Ourselin, S, Crutch, S J, Kuh, D, Fox, N C, Schott, J M & Richards, M 2023, ' Adulthood cognitive trajectories over 26 years and brain health at 70 years of age : findings from the 1946 British Birth Cohort ', Neurobiology of Aging, vol. 122, pp. 22-32 . https://doi.org/10.1016/j.neurobiolaging.2022.10.003
James, S-N, Nicholas, J M, Lu, K, Keshavan, A, Lane, C A, Parker, T, Buchanan, S M, Keuss, S E, Murray-Smith, H, Wong, A, Cash, D M, Malone, I B, Barnes, J, Sudre, C H, Coath, W, Modat, M, Ourselin, S, Crutch, S J, Kuh, D, Fox, N C, Schott, J M & Richards, M 2023, ' Adulthood cognitive trajectories over 26 years and brain health at 70 years of age : findings from the 1946 British Birth Cohort ', Neurobiology of Aging, vol. 122, pp. 22-32 . https://doi.org/10.1016/j.neurobiolaging.2022.10.003
Few studies can address how adulthood cognitive trajectories relate to brain health in 70-year-olds. Participants (n = 468, 49% female) from the 1946 British birth cohort underwent 18F-Florbetapir PET/MRI. Cognitive function was measured in childhood
Autor:
Thomas D. Parker, David M. Cash, Christopher A. Lane, Kirsty Lu, Ian B. Malone, Jennifer M. Nicholas, Sarah‐Naomi James, Ashvini Keshavan, Heidi Murray‐Smith, Andrew Wong, Sarah M. Buchanan, Sarah E. Keuss, Carole H. Sudre, David L. Thomas, Sebastian J. Crutch, Nick C. Fox, Marcus Richards, Jonathan M. Schott
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Cortical thickness has been proposed as a biomarker of Alzheimer's disease (AD)– related neurodegeneration, but the nature of its relationship with amyloid beta (Aβ) deposition and white matter hyperintensity volume (WMHV) in
Externí odkaz:
https://doaj.org/article/cd9606478e5d4d4c8b5a8c069934908e