Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Ian Anthony Cliffe"'
Autor:
Joseph Alex Davis, Biju Benjamin, Shahadat Ahmed, Voleti Sreedhara Rao, Vamshi Krishna Tulasi, Kona S Srinivas, Jitendra A. Sattigeri, Anil Gorakshnath Gadhave, Dhrubajyoti Datta, Balasaheb Gangadhar Jadhav, Abhijit Ray, Ian Anthony Cliffe, Pradip Kumar Bhatnagar, Tarun Jain, Sunitha Udupa, Garima Jain, Satya M. Chilla, Yogender Singh, Sachin Sethi, Geeta Vani Rayasam, Vinay S. Bansal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2313-2318
Designing drug candidates exhibiting polypharmacology is one of the strategies adopted by medicinal chemists to address multifactorial diseases. Metabolic disease is one such multifactorial disorder characterized by hyperglycaemia, hypertension and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d230bbbcb31eefbb1696499371c1800
https://doi.org/10.1016/j.bmcl.2017.04.036
https://doi.org/10.1016/j.bmcl.2017.04.036
Autor:
Abhijit Ray, Venu Pamidiboina, Manish Diwan, Sunanda G. Dastidar, V. Senthil, Tridib Chaira, Biswajit Das, Ruchi Tandon, D. Nithya, Sumit Malik, R. Venkataramanan, Praful Gupta, Ian Anthony Cliffe, Renu Malik, Pradip Kumar Bhatnagar, Ankur Kumar
Publikováno v:
European Journal of Pharmacology. 711:19-26
Pharmacological intervention of epidermal growth factor receptor (EGFR) family members by antibodies or small molecule inhibitors has been one of the most successful approaches for anticancer therapy. However this therapy has its own limitations due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b4ead3d1d20a35b3135855723bd021
https://doi.org/10.1016/j.ejphar.2013.04.016
https://doi.org/10.1016/j.ejphar.2013.04.016
Autor:
Keshav Naik, Viswajanani J. Sattigeri, Ajay Soni, Abhijit Ray, Rauf Abdul Rehman Abdul, Ian Anthony Cliffe, Vanya Shah, Sunanda G. Dastidar, Venkata P. Palle, Mohammad Sarwar Alam, Tridib Chaira
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1482-1485
A novel set of compounds containing a 4,5-dihydro-5-methylisoxazoline have been successfully designed as VLA-4 receptor antagonists. Compound (14p) had a high receptor binding affinity of 4 nM and also found to be metabolically stable in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea4db8974d3f45c82e3594162de824d
https://doi.org/10.1016/j.bmcl.2012.12.043
https://doi.org/10.1016/j.bmcl.2012.12.043
Publikováno v:
Synthetic Communications. 41:1852-1857
A new and efficient method for the demethylation of 6-membered aza-heterocyclic methyl ethers is described using lithium chloride and para-toluenesulfonic acid. This process is chemoselective for aza-heterocyclic methyl ethers in the presence of aryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a6155a550ee2fb5f2caeb2d156340ce
https://doi.org/10.1080/00397911.2010.493262
https://doi.org/10.1080/00397911.2010.493262
Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists
Autor:
Mohammad Sarwar Alam, Keshav Naik, Ajay Soni, Sreeji Nair, Mohammad Salman, Ian Anthony Cliffe, Abhijit Ray, Viswajanani J. Sattigeri, Rauf Abdul Rehman Abdul, Sunanda G. Dastidar, Venkata Palle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5514-5520
A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d012c7b4c6f5653f197a76709ddb57f2
https://doi.org/10.1016/j.bmcl.2010.07.069
https://doi.org/10.1016/j.bmcl.2010.07.069
Publikováno v:
European Journal of Medicinal Chemistry. 45:98-105
The Ser/Thr protein kinase MAPKAP kinase2 (MAPKAPK2 or MK2) plays an important role in inflammation. A comparison of several crystal structures of MK2 shows that differences in active and inactive conformations result in large part from structural va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09db66d3387c5295a04041be34c9362f
https://doi.org/10.1016/j.ejmech.2009.09.030
https://doi.org/10.1016/j.ejmech.2009.09.030
Autor:
A Misra, Jonathan Richard Anthon Roffey, Colin T. Dourish, Joanne Lerpiniere, Rebecca Upton, Roger John Gillespie, Claire Elizabeth Dawson, Suneel Gaur, Scott Murray Weiss, Douglas S. Williamson, Robert M. Pratt, Gemma Caroline Stratton, Ian Anthony Cliffe, Allan M. Jordan, Antony R. Knight
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2924-2929
A series of pyrazolo[3,4-d]pyrimidine, pyrrolo[2,3-d]pyrimidine and 6-arylpurine adenosine A(2A) antagonists is described. Many examples were highly selective against the human A(1) receptor sub-type and were active in an in vivo model of Parkinson's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e62dae2ac4e7e718a360d16ebe430e
https://doi.org/10.1016/j.bmcl.2008.03.072
https://doi.org/10.1016/j.bmcl.2008.03.072
Autor:
David R. Adams, Suneel Gaur, Simon E. Ward, A Misra, Allan Fletcher, Claire Elizabeth Dawson, Porter Richard Hugh Phillip, Anthony Lawrence, P R Giles, Ian Anthony Cliffe, Lars J. S. Knutsen, Colin T. Dourish, Scott Murray Weiss, Roger John Gillespie, Antony R. Knight, Allan M. Jordan, Robert M. Pratt, K Benwell, Douglas S. Williamson, Joanne Lerpiniere, Robin Shepherd, David Bebbington, Rebecca Upton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2916-2919
The (-)-(11R,2'S)-enantiomer of the antimalarial drug mefloquine has been found to be a reasonably potent and moderately selective adenosine A(2A) receptor antagonist. Further investigation of this compound has led to the discovery of a series of ket
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400b9a1d75c6350027c97a4f91d5a4dc
https://doi.org/10.1016/j.bmcl.2008.03.075
https://doi.org/10.1016/j.bmcl.2008.03.075
Autor:
Anita Chugh, Arun D.V. Silamkoti, Suman Gupta, Sankaranarayanan Dharmarajan, Jang Bahadur Gupta, Shelly Aeron, Anita Mehta, Ian Anthony Cliffe, Venkata Palle, Naresh Kumar, Kirandeep Kaur, Mohammad Salman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5256-5260
A series of constrained piperidine analogues were synthesized as novel muscarinic M3 receptor antagonists. Evaluation of these compounds in binding assays revealed that they not only have high affinity for the M3 receptor but also have high selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418d50385901ebd350e1a2125a281401
https://doi.org/10.1016/j.bmcl.2007.06.081
https://doi.org/10.1016/j.bmcl.2007.06.081
Autor:
Biswajit Das, Praful Gupta, Ian Anthony Cliffe, Ruchi Tandon, Pks Sarma, Abhijit Ray, Sunanda G. Dastidar
Publikováno v:
Expert Opinion on Therapeutic Patents. 17:25-35
Insulin-like growth factor-1 receptor (IGF-1R) is a receptor tyrosine kinase that plays a key role in tumor cell proliferation and in the inhibition of apoptosis, and therefore is a potential target for the treatment of cancer. The blockade of IGF-1R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11110ec8168040b0e8b39ca0d7b477ad
https://doi.org/10.1517/13543776.17.1.25
https://doi.org/10.1517/13543776.17.1.25